Removal of phenolic estrogen pollutants from different sources of water using molecularly imprinted polymeric microspheres

Lin, Yi; Shi, Yun; Jiang, Ming; Yuan, Jianmin; Peng, Yan; Lü, Bin; Dai, Kang

doi:10.1016/j.envpol.2007.08.001

Cited by 87 publications

(51 citation statements)

References 35 publications

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“…Among the EDCs, alkyl phenols (for example, NP and octylphenol (OP)), phenolic estrogen mimics (such as BPA), and phenolic estrogens (such as diethylstilbestrol (DES)) are often studied as a group of environmental phenolic estrogens due to their structural similarity and estrogenic activity (Tapiero et al 2002, Lin et al 2008. These phenolic estrogens can act by mimicking the action of the sex hormone E 2 to bind to the classical ERs, ERa and ERb (Newbold 2004), and ERs are involved in important aspects of b-cell physiology, including the regulation of insulin biosynthesis and release (Wozniak et al 2005, Alonso-Magdalena et al 2008.…”

Section: Introductionmentioning

confidence: 99%

Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets

Song¹,

Xia²,

Zhao³

et al. 2012

Journal of Endocrinology

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Phenolic estrogen pollutants, a class of typical endocrinedisrupting chemicals, have attracted public attention due to their estrogenic activities of imitating steroid hormone 17b-estradiol (E 2 ) effects. Exposure to these pollutants may disrupt insulin secretion and be a risk factor for type 2 diabetes. In this study, we investigated the direct effects of phenolic estrogen diethylstilbestrol (DES), octylphenol (OP), nonylphenol (NP), and bisphenol A (BPA) on rat pancreatic islets in vitro, whose estrogenic activities were DESONPOOPOBPA. Isolated b-cells were exposed to E 2 , DES, OP, NP, or BPA (0, 0 . 1, 0 . 5, 2 . 5, 25, and 250 mg/l) for 24 h. Parameters of insulin secretion, content, and morphology of b-cells were measured. In the glucose-stimulated insulin secretion test, E 2 and DES increased insulin secretion in a dose-dependent manner in a 16 . 7 mM glucose condition. However, for BPA, NP, or OP with lower estrogenic activity, the relationship between the doses and insulin secretion was an inverted U-shape. Moreover, OP, NP, or BPA (25 mg/l) impaired mitochondrial function in b-cells and induced remarkable swelling of mitochondria with loss of distinct cristae structure within the membrane, which was accompanied by disruption of mRNA expression of genes playing a key role in b-cell function (Glut2 (Slc2a2), Gck, Pdx1, Hnf1a, Rab27a, and Snap25), and mitochondrial function (Ucp2 and Ogdh). Therefore, these phenolic estrogens can disrupt islet morphology and b-cell function, and mitochondrial dysfunction is suggested to play an important role in the impairment of b-cell function.

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Section: Introductionmentioning

confidence: 99%

Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets

Song¹,

Xia²,

Zhao³

et al. 2012

Journal of Endocrinology

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“…This type of SPE contains very selective and cost-effective materials, which have been proposed in recent years as sorbents for the extraction and/or removal of endocrine disrupting compounds. Providing a new perspective in the analysis of oestrogens (Lin et al 2008;Lucci et al 2011;Meng et al 2005;Sanbe and Haginaka 2003).…”

Section: Introductionmentioning

confidence: 99%

Determination of steroidal oestrogens in tap water samples using solid-phase extraction on a molecularly imprinted polymer sorbent and quantification with gas chromatography-mass spectrometry (GC-MS)

Začs

Pērkons

Bartkevičs

2016

Environ Monit Assess

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An analytical method was established and validated for the analysis of steroidal oestrogens in tap water samples. Gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS) and gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) were used for the identification/quantification of selected compounds and the analytical performance of these techniques was evaluated. Liquid-liquid extraction (LLE) and solid-phase extraction (SPE) with a molecularly imprinted polymer (MIP) stationary phase that was highly selective for oestrogens were used for the extraction of 100-mL aliquots of water samples. The recoveries of analytes with the described methods ranged from 92 to 114 %, while the repeatability in terms of relative standard deviations (RSDs) was in the range from 2.1 to 15.2 % (n = 5). It was concluded that SPE with MIP that was highly selective for oestrogens in combination with GC-HRMS detection is more preferable for the analysis of oestrogens in tap water samples. The typical oestrogen, 17β-estradiol (17β-E2), was detected above the method limit of quantification (m-LOQ) in 5 of 14 analysed tap water samples at concentrations from 0.09 to 0.15 ng L(-1). Despite that 17α-ethynylestradiol (17α-EE2) was not quantified in this study above m-LOQ, the presence of this chemical was qualitatively confirmed in some of the analysed samples.

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“…The presence of RXR antagonistic activity of source waters varied spatially (Figure 1), and RXR antagonists were found to exist in many source waters in China. Various types of environmental contamination by chemical compounds such as anti-oxidants, organochlorines, organophosphates, antimicrobials, estrogens and progestogens, and various types of industrial contamination such as pesticides, pharmaceuticals and personal care products (PPCPs) have been found in source and drinking waters [24][25][26][27][28]. Some of these contaminants have been identified as RXR agonists or antagonists [22] and include Bisphenol A (BPA), multiple phenols, phthalic acid esters (PAEs) and organic chlorine pesticides (OCPs) that have been found in various aquatic systems in China [29][30][31][32].…”

Section: Response To Source Water Extractsmentioning

confidence: 99%

Retinoid X receptor activities of source waters in China and their removal efficiencies during drinking water treatment processes

Jiang

Yan

et al. 2012

Chin. Sci. Bull.

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There is increasing evidence of estrogenic activities of source waters and drinking waters in China based on estrogen receptors (ERs) testing. However, relating such activities to retinoid X receptors (RXRs) in both drinking and source waters are lacking. To rectify this situation, we assessed 23 source water samples from six major river systems in China. We also collected samples at various stages of water processing from three drinking water treatment plants (DWTPs) using a two-hybrid RXR yeast assay with and without metabolism. No RXR agonistic activity was observed, but significant antagonistic activity was detected in all sample extracts. The RXR antagonistic activities of source water sample extracts ranged from 15.2% to 57.8% without metabolism and 11.5% to 68.3% with metabolism, respectively. In the drinking water treatment processes, RXR antagonistic activities without metabolism and with metabolism of up to 31.4% and 37.5% were removed, respectively. Nevertheless, the remaining RXR antagonists in treated drinking water from these source waters could still be harmful to human health. To the best of our knowledge, the occurrence of in vitro RXR disruption activities in source and drinking water has not been previously reported in China. Therefore, an attempt was made to conduct detailed studies investigating RXR disrupting activities and their possible risks in source and drinking water.

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Removal of phenolic estrogen pollutants from different sources of water using molecularly imprinted polymeric microspheres

Cited by 87 publications

References 35 publications

Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets

Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets

Determination of steroidal oestrogens in tap water samples using solid-phase extraction on a molecularly imprinted polymer sorbent and quantification with gas chromatography-mass spectrometry (GC-MS)

Retinoid X receptor activities of source waters in China and their removal efficiencies during drinking water treatment processes

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