Removal of infected nonresorbable hydroxyapatite graft material in recurrent periodontitis: a report of two cases

Sato, Shuichi; Yoshinuma, Naoto; Kishida, Osamu; Fujisaki, Yoshiaki; Ito, Koichi

doi:10.2334/josnusd.51.659

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Although these materials have osteoconductive properties and are effective for filling bone defects, their ability of bone formation may be insufficient in some cases. [5][6][7][8][9] In addition, they remained as remnants without being resorbed or took long time to resorb in the body. Autologous bone grafting has been performed as the first choice in cases where it is necessary to compensate for large bone defects and acquire normal physiological functions as bones, 10,11 whereas it has disadvantages such as surgical invasion requiring bones, namely, the iliac bone, which are collected from other parts of the body, and the amount that can be harvested is insufficient.…”

Section: Introductionmentioning

confidence: 99%

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

et al. 2020

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Octacalcium phosphate and its collagen composite have been recognized as bone substitute materials possessing osteoconductivity and biodegradation properties. We evaluated the effectiveness of octacalcium phosphate and its collagen composite used for bone augmentation in major oral and maxillofacial surgeries in a clinical trial. Octacalcium phosphate and its collagen composite were used in cases of sinus floor elevation in 1- and 2-stage, socket preservation, cyst, and alveolar cleft procedures. A total of 60 patients were evaluated for effectiveness after the implantation of octacalcium phosphate and its collagen composite. Although sinus floor elevation in 1-stage, cyst, and alveolar cleft cases met the criteria for the judgment of success, sinus floor elevation in 2-stage and socket preservation groups did not meet the criteria in the initial evaluation. However, an additional evaluation for reconfirmation revealed the effectiveness of octacalcium phosphate and its collagen composite in those groups, and all evaluation results ultimately indicated the success of this clinical trial. Therefore, this clinical trial suggested that application of octacalcium phosphate and its collagen composite for oral and maxillofacial surgery was safe and effective and that octacalcium phosphate and its collagen composite could be a bone substitute candidate instead of autologous bone.

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Section: Introductionmentioning

confidence: 99%

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

et al. 2020

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“…Concerning complication, infection is well discussed in some case reports and trials [19]. Although the absolute number of infections was increased in the ABP group, there was equality in comparing the groups of treatment (p=1.0).…”

Section: Discussionmentioning

confidence: 99%

Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study

Pawelke¹,

Vinayahalingam²,

Khassawna³

et al. 2023

Preprint

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When bone substitutes materials are used, the increased risk of infection due to the none-autogenic graft is often discussed. The treatment of large bone defects in geriatric patients, often with osteoporotic bone, often presents major challenges to surgery. Bone substitutes materials are available indefinitely without the risk of additional surgery in each patient. Can bone substitutes materials be used without hesitation in the geriatric patient? Eighty-three patients suffered traumatic fractures of the distal radius, proximal humerus, and proximal tibia. The defect zones were filled with bone substitute material based on nanocrystalline hydroxyapatite (NHA) or calcium phosphate (CP). For comparison, a reference group without the void filling with a bone graft substitute (void defects, ED) was studied. All patients over the age of 64 years were retrospectively evaluated for complications and radiological outcomes. Results: 106 patients sustained traumatic fractures of the distal radius (68.9%), proximal humerus (5.7%), and proximal tibia (22.6%). No differences in infections were found when comparing the groups (p=1.0). retrospectively evaluated. The KEM group had a nonsignificantly lower rate of pseudarthrosis (p=0.09). A relative risk (RR) reduction of complications of 32.64% was observed when bone grafting material was used. The NNT for the prevention of complications was 5.99. When bone healing was assessed by radiological images, some follow-up studies showed significant differences in fracture bridging (p<0.001). Conclusions: In contrast to previous studies, bone substitutes materials can support the healing process in geriatric patients without relevant disadvantages. With an NNT of 6 regarding complications, many patients could benefit from bone graft augmentation. No increased infection rate was observed.

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“…Concerning complications, infection is well discussed in some case reports and trials [ 21 ]. Although the absolute number of infections was increased in the ABP group, there was equality in comparing the groups of treatment ( p = 1.0).…”

Section: Discussionmentioning

confidence: 99%

Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients: An Observational Study

et al. 2023

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Background and Objectives: he treatment of large bone defects in geriatric patients often presents a major surgical challenge because of age-related bone loss. In such patients, the scarcity of healthy makes autologous grafting techniques hard to perform. On the one hand, clinicians’ fear of possible infections limits using bone substitute materials (BSM). On the other hand, BSM is limitless and spares patients another surgery to harvest autologous material. Materials and Methods: To address the aptness of BSM in geriatric patients, we performed a retrospective analysis of all patients over the age of 64 years who visited our clinic between the years 2011–2018. The study assessed postoperative complications clinically and healing results radiologically. The study included 83 patients with bone defects at the distal radius, proximal humerus, and proximal tibia. The defect zones were filled with BSM based on either nanocrystalline hydroxyapatite (NHA) or calcium phosphate (CP). For comparison, a reference group (empty defect, ED) without the void filling with a BSM was also included. Results: 106 patients sustained traumatic fractures of the distal radius (71.7%), proximal humerus (5.7%), and proximal tibia (22.6%). No difference was found between the BSM groups in infection occurrence (p = 1.0). Although not statistically significant, the BSM groups showed a lower rate of pseudarthrosis (p = 0.09) compared with the ED group. Relative risk (RR) of complications was 32.64% less in the BSM groups compared with the ED group. The additional beneficial outcome of BSM was demonstrated by calculating the number needed to treat (NNT). The calculation showed that with every six patients treated, at least one complication could be avoided. Radiological assessment of bone healing showed significant improvement in the bridging of the defect zone (p < 0.001) when BSM was used. Conclusions: In contrast to previous studies, the study showed that BSM could support bone healing and does not present an infection risk in geriatric patients. The NNT calculation indicates a wider potential benefit of BSM.

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Removal of infected nonresorbable hydroxyapatite graft material in recurrent periodontitis: a report of two cases

Cited by 5 publications

References 8 publications

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients– An Observational Study

Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients: An Observational Study

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