Removal of Erythrocytes from the Circulation

Wagner, Henry N.; Razzak, Mohamed A.; Gaertner, Robert A.; Caine, Winston P.; Feagin, O. Thomas

doi:10.1001/archinte.1962.03620190092014

Cited by 72 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These observations suggested that splenomegaly per se, rather than a specific antiplasmodial alteration in splenic function, was the basis for the accelerated clearance in immune rats. The greater ability of enlarged spleens to remove infected erythrocytes is likely to depend upon the increased efficiency of the hypertrophied organ to remove poorly deformed erythrocytes (33). Support for this notion derives from our observations that aniother poorly deformable erythrocyte, the Heinz body-containing cell, is also cleared from circulation more readily in the setting of splenomegaly, whether induced by malaria (Fig.…”

Section: Discussionmentioning

confidence: 69%

Intravascular Clearance of Parasitized Erythrocytes in Rodent Malaria

Quinn

Wyler

1979

J. Clin. Invest.

View full text Add to dashboard Cite

A B ST RA CT Little is known about host defense mechanisms responsible for protective immunity in malaria. The intravascular location of the infection suggested that removal of parasitized erythrocytes by reticuloendothelial organs might be important. To study this possibility, we examined the clearance of 51Cr-labeled Plasmodiumn berghei-infected erythrocytes in rats. Infected erythrocytes were removed more rapidly from circulation than homologous uninfected erythrocytes. The rate of clearance of infected cells during the 1st hour after inoculation was approximately three times greater in rats rendered immune by prior infection than in control rats. This accelerated clearance resulted from greater splenic uptake in immune rats and appeared to correlate with spleen size. Since the clearance pattern of infected erythrocytes more closely resembled the clearance of Heinz body-containing uninfected erythrocytes than of antibody-coated (immunoglobulin G) uninfected erythrocytes, rheologic alterations of parasitized erythrocytes might be a more important determinant of clearance than an anitibodydependent process. During the phase of malaria infection in which increasing parasitemia is observed, organ uptake of infected erythrocytes did not increase despite splenic and hepatic enlargement. However during the spontaneous onset of resolution of malaria infection characterized by decreasing parasitemia, a marked enhancement of splenic clearance was noted. These observations suggest that sudden alteration in splenic clearance of parasitized erythrocytes might be important in the resolution of acute malaria.

show abstract

Section: Discussionmentioning

confidence: 69%

Intravascular Clearance of Parasitized Erythrocytes in Rodent Malaria

Quinn

Wyler

1979

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…In previous studies employing thermally damaged Cr51-labeled red cells to assess the size of the spleen by a scanning procedure, both we (8) and Wagner and co-workers (9) found that the cells tended to disappear from circulating blood more rapidly in patients with cirrhosis than in control subjects. The present investigation was conducted in order that the rate of removal of thermally damaged cells might be measured definitively by analysis either of blood disappearance curves or of curves obtained by continuous recording of activity through an external probe placed over the spleen.…”

mentioning

confidence: 67%

Influence of Spleen Size and Portal Pressure on Erythrocyte Sequestration*

Holzbach¹,

Shipley²,

Clark³

et al. 1964

J. Clin. Invest.

View full text Add to dashboard Cite

“…Erythrocytes which have been damaged by physical, chemical, or immunological means appear to be handled in a similar manner (2)(3)(4) although the relative importance of various tissue sites in the removal of these damaged cells may differ from that of physiologically aged erythrocytes (2,5). Red cells extruded into extravascular sites are phagocytized and degraded by mononuclear macrophages which converge at these sites (6,7).…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte Catabolism by Macrophages In Vitro THE EFFECT OF HYDROCORTISONE ON ERYTHROPHAGOCYTOSIS AND ON THE INDUCTION OF HEME OXYGENASE

Gemsa¹,

Woo²,

Fudenberg³

et al. 1973

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Phagocytosis of erythrocytes was studied in vitro in an incubation system consisting of rat peritoneal macrophages and antibody-coated 'Fe-labeled erythrocytes. The system was characterized in terms of the rate and magnitude of erythrophagocytosis, determined by the interiorization of the 'Fe label. On incubation of 150 X 106 macrophages with 75 X 10 antibodycoated erythrocytes, erythrophagocytosis began within a few minutes and was essentially completed after 2 h when 50% of the offered red cells had been ingested by the macrophages. Heme oxygenase (HO) activity, which is very low in native macrophages, increased 4-to 10-fold in response to the ingested erythrocytes; this enzyme stimulation occurred with a delay of 3 h in relation to erythrophagocytosis. Actinomycin D or puromycin prevented the increase of HO activity without affecting erythrophagocytosis, which suggests that the enzyme stimulation was due to substrate-mediated enzyme induction.Hydrocortisone (HC) (0.1 mg/ml medium) dissociated erythrophagocytosis from HO induction, leaving the former unimpaired but completely suppressing the latter. The suppressive effect of HC on the enzyme induction was completely prevented by 5 mg glucose and 0.02 U insulin/ml of the medium. In macrophages engaged in erythrophagocytosis, HC also lowered glucose removal from the medium and reduced formation ofThese results suggest that induction of HO in macrophages by the hemoglobin of ingested erythrocytes requires intact transport or metabolism of glucose. GlucoseThis work was presented in part at

show abstract

Removal of Erythrocytes from the Circulation

Cited by 72 publications

References 9 publications

Intravascular Clearance of Parasitized Erythrocytes in Rodent Malaria

Intravascular Clearance of Parasitized Erythrocytes in Rodent Malaria

Influence of Spleen Size and Portal Pressure on Erythrocyte Sequestration*

Erythrocyte Catabolism by Macrophages In Vitro THE EFFECT OF HYDROCORTISONE ON ERYTHROPHAGOCYTOSIS AND ON THE INDUCTION OF HEME OXYGENASE

Contact Info

Product

Resources

About