Removal of Cell‐Activating Substances Using Dialyzers With Various Permeability Profiles

Latosinska, Agnieszka; Hulko, Michael; Speidel, Rose; Mischak, Harald; Storr, Markus; Krause, Bernd

doi:10.1111/aor.12952

Cited by 10 publications

(10 citation statements)

References 35 publications

(46 reference statements)

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“…Agnieszka Latosinska et al of Mosaiques Diagnostics GmbH, Hannover, Germany, reported on the removal of cell‐activating substances from the blood using dialyzers with various permeability profiles. Dialysate samples were collected using Revaclear 400 (RC) and MCO‐Ci400 (MCO‐CI) and the total protein and solute marker concentrations were determined for the concentrated sample.…”

Section: Renal Support and Dialysismentioning

confidence: 99%

“…The method estimated the total condensate output, combining computational fluid dynamics (CFD) of thermal distribution and a simplified 1D model of water vapor saturation of gas. Results showed that condensation rate could vary in a 30-fold range within reasonably small variations of the different variables considered.10 | RENAL SUPPORT AND DIALYSISAgnieszka Latosinska et al102 of Mosaiques Diagnostics GmbH, Hannover, Germany, reported on the removal of cellactivating substances from the blood using dialyzers with various permeability profiles. Dialysate samples were collected using Revaclear 400 (RC) and MCO-Ci400 (MCO-CI) and the total protein and solute marker concentrations were determined for the concentrated sample.…”

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confidence: 99%

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Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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In this Editor's Review, articles published in 2018 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed special issues this year included contributions from the 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, and the 25th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Marvin Slepian. Additionally, many editorials highlighted the worldwide survival differences in hemodialysis and perspectives on mechanical circulatory support and stem cell therapies for cardiac support. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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Section: Renal Support and Dialysismentioning

confidence: 99%

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confidence: 99%

Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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“…More recently, removal of cell-activating substances from uremic blood was investigated in dialysate samples collected during HD with a high-flux membrane and a medium-cut-off membrane (MCO-CI) which has a higher permeability. 29 The latter is a new designed highly porous and selective membrane, characterized by permeability and pore size distribution similar to the kidney itself. 30 Treatment of tubular epithelial cells as an experimental model with the MCO-CI dialysate, as compared to high-flux dialysate, was associated with a significant decrease in cell viability and with loss of brick-like shape of the cell and cell–cell connections.…”

Section: Introductionmentioning

confidence: 99%

“… 30 Treatment of tubular epithelial cells as an experimental model with the MCO-CI dialysate, as compared to high-flux dialysate, was associated with a significant decrease in cell viability and with loss of brick-like shape of the cell and cell–cell connections. 29 The observed phenotype is supported by proteomic analysis (liquid chromatography–MS/MS) coupled with bioinformatics tools, of dialysate samples. Functional classification of proteins overrepresented in samples obtained from HD with MCO-CI revealed the presence of many enzymes (oxidoreductases, transferases, isomerases, and enzyme modulators), signaling molecules, cell adhesion molecules, transfer proteins, immunity proteins, and multiple proteins known to affect tubular epithelial cells’ viability and morphology.…”

Section: Introductionmentioning

confidence: 99%

“…Functional classification of proteins overrepresented in samples obtained from HD with MCO-CI revealed the presence of many enzymes (oxidoreductases, transferases, isomerases, and enzyme modulators), signaling molecules, cell adhesion molecules, transfer proteins, immunity proteins, and multiple proteins known to affect tubular epithelial cells’ viability and morphology. 29 Proteomic findings were linked by toxicity functional analysis to renal, cardiovascular, and liver toxicity. In addition, pathway analysis showed the proteins mostly removed by MCO-CI dialyzer to be involved in inflammatory responses, cellular stress and injury, cellular growth and proliferation, cardiovascular signaling, and nuclear receptor signaling.…”

Section: Introductionmentioning

confidence: 99%

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Examining hemodialyzer membrane performance using proteomic technologies

Bonomini¹,

Pieroni²,

Liberato³

et al. 2017

TCRM

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The success and the quality of hemodialysis therapy are mainly related to both clearance and biocompatibility properties of the artificial membrane packed in the hemodialyzer. Performance of a membrane is strongly influenced by its interaction with the plasma protein repertoire during the extracorporeal procedure. Recognition that a number of medium–high molecular weight solutes, including proteins and protein-bound molecules, are potentially toxic has prompted the development of more permeable membranes. Such membrane engineering, however, may cause loss of vital proteins, with membrane removal being nonspecific. In addition, plasma proteins can be adsorbed onto the membrane surface upon blood contact during dialysis. Adsorption can contribute to the removal of toxic compounds and governs the biocompatibility of a membrane, since surface-adsorbed proteins may trigger a variety of biologic blood pathways with pathophysiologic consequences. Over the last years, use of proteomic approaches has allowed polypeptide spectrum involved in the process of hemodialysis, a key issue previously hampered by lack of suitable technology, to be assessed in an unbiased manner and in its full complexity. Proteomics has been successfully applied to identify and quantify proteins in complex mixtures such as dialysis outflow fluid and fluid desorbed from dialysis membrane containing adsorbed proteins. The identified proteins can also be characterized by their involvement in metabolic and signaling pathways, molecular networks, and biologic processes through application of bioinformatics tools. Proteomics may thus provide an actual functional definition as to the effect of a membrane material on plasma proteins during hemodialysis. Here, we review the results of proteomic studies on the performance of hemodialysis membranes, as evaluated in terms of solute removal efficiency and blood–membrane interactions. The evidence collected indicates that the information provided by proteomic investigations yields improved molecular and functional knowledge and may lead to the development of more efficient membranes for the potential benefit of the patient.

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The Inability of Podocytes to Proliferate: Cause, Consequences, and Origin

Kriz

2019

The Anatomical Record

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This study presents a theoretical analysis of the problems related to the inability of podocytes to proliferate. The basis of these problems is the very high rate of glomerular filtration. Podocytes do not in general die by apoptosis or necrosis but are lost by detachment from the glomerular basement membrane (GBM) as viable cells. Podocytes situated on the outside of the filtration barrier and attached to the GBM only by their foot processes are permanently exposed to the flow dynamic forces of the high filtration rate tending to detach them from the GBM. The major challenge seems to consist of the high shear stresses on the foot processes within the filtration slits due to filtrate flow. Healthy podocytes are able to resist this challenge, injured podocytes are not, and may undergo foot process detachment, leading to a gap in the podocyte cover of the GBM. This represents a mortal event. Like a dam break, such a leak cannot be repaired. The ongoing exposure to filtrate flow prevents any attempt to close the gap, thus preventing any regeneration including cell proliferation. An improvement of this precarious situation consists of healing by scarring that may involve only one lobule of the glomerulus, permitting the remaining lobules to maintain filtration. An answer to the question of which waste product requires such a high filtration rate for its excretion may be in the huge quantity of circulating peptides, a problem that dates far back in evolution.

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Removal of Cell‐Activating Substances Using Dialyzers With Various Permeability Profiles

Cited by 10 publications

References 35 publications

Artificial Organs 2018: A Year in Review

Artificial Organs 2018: A Year in Review

Examining hemodialyzer membrane performance using proteomic technologies

The Inability of Podocytes to Proliferate: Cause, Consequences, and Origin

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