Bioprocesses, such as biofiltration, are commonly used to treat industrial effluents containing volatile organic compounds (VOCs) at low concentrations. Nevertheless, the use of biofiltration for indoor air pollution (IAP) treatment requires adjustments depending on specific indoor environments. Therefore, this study focuses on the convenience of a hybrid biological process for IAP treatment. A biofiltration reactor using a green waste compost was combined with an adsorption column filled with activated carbon (AC). This system treated a toluene-micropolluted effluent (concentration between 17 and 52 µg/m 3 ), exhibiting concentration peaks close to 733 µg/m 3 for a few hours per day. High removal efficiency was obtained despite changes in toluene inlet load (from 4.2 × 10 −3 to 0.20 g/m 3 /hr), which proves the hybrid system's effectiveness. In fact, during unexpected concentration changes, the efficiency of the biofilter is greatly decreased, but the adsorption column maintains the high efficiency of the entire process (removal efficiency [RE] close to 100%). Moreover, the adsorption column after biofiltration is able to deal with the problem of the emission of particles and/or microorganisms from the biofilter.Implications: Indoor air pollution is nowadays recognized as a major environmental and health issue. This original study investigates the performance of a hybrid biological process combining a biofilter and an adsorption column for removal of indoor VOCs, specifically toluene.