Advanced oxidation processes are attractive methods for treating wastewater containing refractory organic substances. Hybrid reactors utilizing mist generated by ultrasound and photocatalysts have been proposed to enhance pollutant removal. However, the functions of ultraviolet, ultrasound, mist, and photocatalyst in the hybrid reactor have not been clarified. The aim of this study is to investigate these functions by comparing the pollutant removal performance under different operating conditions. The results indicate that the application of ultraviolet, ultrasound, and photocatalyst is necessary to utilize mist as a reaction field. A synergistic effect of the simultaneous application was observed in the hybrid reactor.