Removal of 238Pu(IV) from Mice by Poly-Catechoylate, -Hydroxamate or -Hydroxypyridinonate Ligands

Durbin, Patricia W.; Jeung, Nylan; Rodgers, S. J.; Turowski, Petra N.; Weitl, Frederick L.; White, David L.; Raymond, K.N.

doi:10.1093/oxfordjournals.rpd.a080429

Cited by 46 publications

(67 citation statements)

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“…These results supported the finding that the removal effect of 3, 4, 3-LIHOPO is superior to that of Ca-DTPA. 16,17,26) The effects of the 3, 4, 3-LIHOPO in this study was greater than those previous studies,17,24,25) probably due to the different administration routes of plutonium, e. g., inhalation and subcutaneous muscles. As well the timing of the administration of chelating agents after plutonium administration, because the effects of chelating agents depends on the plutonium concentration in the blood and the clearance time of the chelating agent.…”

Section: Discussioncontrasting

confidence: 62%

“…However, as the effect of a single administration of Ca-DTPA for removing plutonium is low,14) a long term chelation therapy may be necessary. 15) After DTPA, as an agent superior to Ca-DTPA, linear tetrahydroxypydinone (3,4, in Western countries, [16][17][18][19][20][21][22][23][24][25][26] and Catechol-3, 6-bis (methyleiminodiaetic acid) (CBMIDA) and their analogues in Japan and China27,28) have been developed. Comparisons of CBMIDA and Ca-DTPA,27) and Zn-DTPA,27,28) and of 3, 4, 3-LIHOPO and Ca-DTPA17, 18,22,[24][25][26] in regard to their removal of plutonium have been performed.…”

Section: Introductionmentioning

confidence: 99%

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Efficacies of Three Chelating Agents on Removal of Plutonium in Rats: Comparison of CBMIDA, 3,4,3-LIHOPO and Ca-DTPA

Fukuda¹,

Iida²,

Yan

et al. 2003

Jpn. J. Health Phys.

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The effects of three chelating agents, CBMIDA, 3, 4, 3-LIHOPO, and Ca-DTPA, for removing Pu-239 in rats were compared. Forty female Wistar rats, 2 months old, were pre-injected intraperitoneally with 37,000Bq/kg of plutonium nitrate and divided into four groups. Thereafter the rats of three groups were injected intraperitoneally with three chelating agents at a dose of 30umol/kg, equivalent to a daily recommended human dose of Ca-DTPA, at intervals of 24hr for 3 days, beginning 30min after plutonium injection on the first day of treatment. Urine and feces were collected every 24hr. On day 4, the rats were sacrificed to obtain organs including the liver, kidney, and spleen, as well as the femur and serum. The amounts of excreted plutonium in urine of the CBMIDA and Ca-DTPA groups were increased significantly over that in the 3, 4, 3-LIHOPO and control groups, while those in the feces of the 3, 4, 3-LIHOPO group were increased significantly over the other groups on the first day. The total amount of excreted plutonium by 3 day-treatments was highest in the 3, 4, 3-LIHOPO group. The toxicity of each agent was discussed. It is concluded that at the same doses, the effect of 3, 4, 3-LIHOPO was superior to CBMIDA and Ca-DTPA for removing plutonium in rats.

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Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Efficacies of Three Chelating Agents on Removal of Plutonium in Rats: Comparison of CBMIDA, 3,4,3-LIHOPO and Ca-DTPA

Fukuda¹,

Iida²,

Yan

et al. 2003

Jpn. J. Health Phys.

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“…Mn 2ϩ resistance has been used as a selection strategy to obtain fur mutants in several bacteria (12,16,39), and the Fur-binding site for regulatory active Fe 2ϩ may be occupied in vitro by Co 2ϩ , Mn 2ϩ , or other divalent cations (17), raising the possibility that intracellular Sr 2ϩ may interfere with normal Fur function. Iron-chelating siderophores from other microorganisms have been shown to bind other metals, such as thorium, uranium, vanadium, and plutonium (3,8,20,40,47). One possibility is that S. oneidensis cells were unable to increase cellular iron upon exposure to SrCl 2 because the competition of Sr with iron for specific binding sites in iron-sensing proteins or siderophores led to high expression levels for iron acquisition genes.…”

Section: Discussionmentioning

confidence: 99%

Cellular Response of Shewanella oneidensis to Strontium Stress

Brown

Martin

Deshpande

et al. 2006

Appl Environ Microbiol

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The physiology and transcriptome dynamics of the metal ion-reducing bacterium Shewanella oneidensis strain MR-1 in response to nonradioactive strontium (Sr) exposure were investigated. Studies indicated that MR-1 was able to grow aerobically in complex medium in the presence of 180 mM SrCl 2 but showed severe growth inhibition at levels above that concentration. Temporal gene expression profiles were generated from aerobically grown, mid-exponential-phase MR-1 cells shocked with 180 mM SrCl 2 and analyzed for significant differences in mRNA abundance with reference to data for nonstressed MR-1 cells. Genes with annotated functions in siderophore biosynthesis and iron transport were among the most highly induced (>100-fold [P < 0.05]) open reading frames in response to acute Sr stress, and a mutant (SO3032::pKNOCK) defective in siderophore production was found to be hypersensitive to SrCl 2 exposure, compared to parental and wild-type strains. Transcripts encoding multidrug and heavy metal efflux pumps, proteins involved in osmotic adaptation, sulfate ABC transporters, and assimilative sulfur metabolism enzymes also were differentially expressed following Sr exposure but at levels that were several orders of magnitude lower than those for iron transport genes. Precipitate formation was observed during aerobic growth of MR-1 in broth cultures amended with 50, 100, or 150 mM SrCl 2 but not in cultures of the SO3032::pKNOCK mutant or in the abiotic control. Chemical analysis of this precipitate using laser-induced breakdown spectroscopy and static secondary ion mass spectrometry indicated extracellular solid-phase sequestration of Sr, with at least a portion of the heavy metal associated with carbonate phases.The toxic heavy metal and radionuclide waste derived from defense-related activities and various industrial processes can seriously impact the health of ecosystems and humans. In situ bioremediation exploiting the intrinsic respiratory processes of dissimilatory metal ion-reducing bacteria (DMRB) has been proposed as a potential strategy for the reductive immobilization or detoxification of environmental contaminants. Microbial cell walls, for example, can serve as templates for nucleation of metal precipitates (4), and metal-reducing bacteria can directly convert metal pollutants from a soluble, mobile form to a sparingly soluble, less bioavailable form (28), thus facilitating contaminant removal from contained-storage and natural sites. Microbially mediated immobilization of toxic metals and radionuclides can occur as a result of precipitation through formation of metal-metabolite/ligand complexes, nonenzymatic biosorption, or bioaccumulation by energy-dependent transport systems (reviewed in references 4, 13,

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“…For example, the formation constants for the complexes of the hydroxamate siderophore desferrioxamine B with (8). Siderophores also bind strongly to actinides, including thorium, uranium, neptunium, and plutonium (18,28,33,34,39).…”

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confidence: 99%

The Pseudomonas aeruginosa Pyochelin-Iron Uptake Pathway and Its Metal Specificity

et al. 2009

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Pyochelin (Pch) is one of the two major siderophores produced and secreted by Pseudomonas aeruginosa PAO1 to assimilate iron. It chelates iron in the extracellular medium and transports it into the cell via a specific outer membrane transporter, FptA. . Surprisingly, the Pch complexes with all these metals bound to FptA with affinities in the range of 10 nM to 4.8 M (the affinity of Pch-Fe is 10 nM) and were able to inhibit, with various efficiencies, Pch-55 Fe uptake in vivo. We used inductively coupled plasma atomic emission spectrometry to follow metal uptake by P. aeruginosa. Energydependent metal uptake, in the presence of Pch, was efficient only for Fe 3؉ . Co 2؉ , Ga 3؉ , and Ni 2؉ were also transported, but the uptake rates were 23-to 35-fold lower than that for Fe 3؉ . No uptake was seen for all the other metals. Thus, cell surface FptA has broad metal specificity at the binding stage but is much more selective for the metal uptake process. This uptake pathway does not appear to efficiently assimilate any metal other than Fe 3؉ .

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Removal of 238Pu(IV) from Mice by Poly-Catechoylate, -Hydroxamate or -Hydroxypyridinonate Ligands

Cited by 46 publications

References 0 publications

Efficacies of Three Chelating Agents on Removal of Plutonium in Rats: Comparison of CBMIDA, 3,4,3-LIHOPO and Ca-DTPA

Efficacies of Three Chelating Agents on Removal of Plutonium in Rats: Comparison of CBMIDA, 3,4,3-LIHOPO and Ca-DTPA

Cellular Response of Shewanella oneidensis to Strontium Stress

The Pseudomonas aeruginosa Pyochelin-Iron Uptake Pathway and Its Metal Specificity

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