Case PresentationS.K., a 50 year old white female who lived all of her life in central Texas, presented in mid-1996 with cloudy dialysate after having undergone successful continuous ambulatory peritoneal dialysis (CAPD) for 18 months. The white blood cell (WBC) count in the dialysate was 250/mm 3 with 80 percent granulocytes and 20 percent monocytes. Initial therapy was vancomycin 2 grams in one overnight exchange and gentamicin 15 mg in each exchange pending culture reports. Within 48 hours, the WBC count in the dialysate (on a four hour dwell) had fallen to 150/mm 3 ; all cultures were sterile. The patient was previously known to have a chronic exit site infection. An ultrasound of her catheter tunnel was remarkable for some fluid accumulation along the catheter track consistent with a tunnel infection. Multiple cultures were obtained with only one set yielding staphylococcus aureus. The initially low WBC, however, was felt to mitigate against true staphylococcus aureus peritonitis. The issue of a possible vancomycin induced WBC elevation in the dialysate was also considered and antibiotics were subsequently discontinued. The patient was carefully observed over a five to six day period, in which her dialysate remained only mildly cloudy and the WBC (on four hour dwells) varied between 150 and 525 WBC's/mm 3 with 95% polys. Repeated reculturing of the dialysate failed to grow any pyogenic organism.Additional questioning of the patient about her past medical history revealed a history of a chronic low grade fever beginning eight months prior to the onset of peritonitis. She experienced night sweats, anorexia, decreased exercise tolerance and weight loss. She also developed progressive anemia and hypoalbuminemia. In spite of the ingestion of dietary protein supplements, her serum albumin remained between 2.0 and 2.5 grams percent. Her anemia was characterized as a macrocytic anemia but vitamin B12 and folic acid serum concentrations on several examinations were normal. In addition, her reticulocyte count was between 1.2 and 1.6 and could not explain the macrocy-tosis. Her history also included heavy alcohol ingestion, and she smoked 2-3 packages of cigarettes per day for an excess of 15 years. The question of alcoholic hepatitis, cirrhosis, underdialysis and malabsorption were all considered as possible underlying causes of the patient's ''failure to thrive.'' Ultimately, fluconazole therapy was initiated based on the clinical suspicion of yeast peritonitis. Three weeks after the initial presentation of cloudy dialysate, during which time the dialysate was still slightly hazy and the WBC count in the dialysate remained at 200/mm 3 , one of the initial cultures grew Histoplasma capsulatum. The catheter was removed within 24 hours. Subsequently, itraconazole therapy was stated and the patient was converted to intermittent hemodialysis. Within 48 hours after treatment with itraconazole, the patient had a defervescence, an increase in appetite, a resolution of her anorexia and an increase in physical endurance. Durin...