Removable dental prostheses and cardiovascular survival: A 15-year follow-up study

Janket, Sok‐Ja; Surakka, Markku; Jones, Judith A.; Lam, Alice; Schnell, Ronni A.; Rose, Lynda M.; Walls, Angus; Meurman, Jukka H.

doi:10.1016/j.jdent.2013.05.009

Cited by 17 publications

(17 citation statements)

References 37 publications

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“…, Janket et al. ). As far as we know, our study is the first study that formally tested whether the relationship of the number of teeth to CVD mortality was mediated by systemic inflammation as assessed by fibrinogen and CRP levels.…”

Section: Discussionmentioning

confidence: 99%

Number of teeth, C‐reactive protein, fibrinogen and cardiovascular mortality: a 15‐year follow‐up study in a Finnish cohort

Janket

Baird

Jones

et al. 2013

J Clinic Periodontology

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Aim(s) To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival. Materials and Methods The Kuopio Oral Health and Heart study initiated a case-control study in 1995–1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender matched controls. We appended the mortality data and formulated a longitudinal study. By May 31st, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) – consisting of 10 teeth – with cardiovascular and all-cause mortality after 15.8 years of median follow-up. Results In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular (CVD) mortality with a Hazard Ratio (HR) 0.73, P-value = 0.02 but not with all-cause mortality (HR= 0.87, p=0.13). The findings were not mediated by CRP levels ≥ 3 mg/L or by median fibrinogen levels but were mediated by CRP levels > 5 mg/L. Conclusion Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.

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Section: Discussionmentioning

confidence: 99%

Number of teeth, C‐reactive protein, fibrinogen and cardiovascular mortality: a 15‐year follow‐up study in a Finnish cohort

Janket

Baird

Jones

et al. 2013

J Clinic Periodontology

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“…Forth, many important confounders, like economic status, were not adjusted in most previous studies [5][6][7][8][9][10][11][12][13]. Fifth, previous studies evaluating denture use and mortality showed inconsistent results [13,21]. Lastly, tooth loss and the denture use may change over time, but no previous studies have considered the variability over time in evaluating the effect.…”

Section: Introductionmentioning

confidence: 99%

Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study

Yuan

Kraus

et al. 2020

BMC Oral Health

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Background: The associations between the number of natural teeth/denture use and all-cause mortality remain unclear due to lake of investigation for the potential interaction between tooth loss and denture use and for the potential changes in these exposures over time in older adults. We undertake this study to evaluate the associations of the number of natural teeth and/or denture use with mortality in Chinese elderly. Methods: This is a prospective cohort study of 36,283 older adults (median age: 90). The number of natural teeth and denture use were collected with structured questionnaire. We evaluated hazard ratios (HRs) and confidence intervals (CIs) using a Cox proportional hazards model adjusting for demographic factors, education, income, lifestyle factors, and comorbidities. Results: We documented 25,857 deaths during 145,947 person-years of observation. Compared to those with 20+ teeth, tooth loss was associated with a gradual increase in mortality, with an adjusted HR of 1.14 (95% CI, 1.06 to 1.23) for those with 10-19 teeth, 1.23 (95% CI, 1.15 to 1.31) for those with 1-9 teeth, and 1.35 (95% CI, 1.26 to 1.44) for those without natural teeth. Denture use was associated with lower risk of mortality (adjusted HR 0.81; 95% CI, 0.77 to 0.84). Subgroup analyses indicated that the benefit of denture use was greater in men than in women (P = 0.02) and tended to decrease with age (P < 0.001). The effects of denture use did not differ among various degrees of tooth loss (P = 0.17). Conclusions: Tooth loss was associated with an increased risk of mortality in older adults. Denture use provided a protective effect against death for all degrees of tooth loss however, this effect appeared to be modified by sex and age.

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“…Janket et al evaluated the role of removable prostheses on cardiovascular survival in a 15‐year cross‐sectional study. In 256 participants, they found that partially edentulous patients with an RDP had a lower risk for cardiovascular mortality than those who were fully dentate; however, those with complete dentures, or with a complete denture opposing an RDP had a higher risk of mortality.…”

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confidence: 99%

Complete Edentulism and Comorbid Diseases: An Update

Felton

2015

Journal of Prosthodontics

111

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The relationship between complete edentulism, which is the terminal outcome of a multifactorial oral disease process and other comorbid diseases, was first reported in 2009. Although the relationship between edentulism and a multitude of systemic diseases was reported, none of the publications studied could determine causality of tooth loss on the incidence of any comorbid disease. Since that publication, there has been a renewed interest in this relationship, and a plethora of new articles have been published. This article will provide an update on articles published since 2008 on the relationship between edentulism and comorbid diseases, and will include the relationship between complete edentulism and such comorbid conditions as malnutrition, obesity, cardiovascular disease, rheumatoid arthritis, pulmonary diseases (including chronic obstructive pulmonary disease), cancer, and even mortality.

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Removable dental prostheses and cardiovascular survival: A 15-year follow-up study

Cited by 17 publications

References 37 publications

Number of teeth, C‐reactive protein, fibrinogen and cardiovascular mortality: a 15‐year follow‐up study in a Finnish cohort

Number of teeth, C‐reactive protein, fibrinogen and cardiovascular mortality: a 15‐year follow‐up study in a Finnish cohort

Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study

Complete Edentulism and Comorbid Diseases: An Update

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