Remotely Triggered Release from Magnetic Nanoparticles

Derfus, Austin M.; Maltzahn, Geoffrey von; Harris, Tony; Duza, Tasmia; Vecchio, Kenneth S.; Ruoslahti, Erkki; Bhatia, Sangeeta N.

doi:10.1002/adma.200700091

Cited by 259 publications

(179 citation statements)

References 28 publications

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“…12). [105] The particles transduce external electromagnetic force (EMF) at 350-400 kHz to local heating for breaking hydrogen bonds between DNA chains. …”

Section: Nanoparticles As Drug Delivery Systemsmentioning

confidence: 99%

Applications of Nanoparticles in Biology

2008

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“…12). [105] The particles transduce external electromagnetic force (EMF) at 350-400 kHz to local heating for breaking hydrogen bonds between DNA chains. …”

Section: Nanoparticles As Drug Delivery Systemsmentioning

confidence: 99%

Applications of Nanoparticles in Biology

2008

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“…Among them, pulsatile drug delivery systems (PDDS) have drawn attention as they allow repeatable and reliable drug release flux for clinical needs. Further, external stimulation signals such as temperature variation, 9,10 magnetic fields, [11][12][13][14] and electric fields, [15][16][17][18][19][20][21] can be used in PDDS to trigger or control drug release rates, thereby allowing remote control of local drug administration. Most of the PDDS devices are composed of a drug-loading container covered with a functional membrane, with drug release rates through the functional membrane controlled by modulating the external stimulations.…”

Section: Introductionmentioning

confidence: 99%

Programmable and on-demand drug release using electrical stimulation

Sun

et al. 2015

Biomicrofluidics

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Recent advancement in microfabrication has enabled the implementation of implantable drug delivery devices with precise drug administration and fast release rates at specific locations. This article presents a membrane-based drug delivery device, which can be electrically stimulated to release drugs on demand with a fast release rate. Hydrogels with ionic model drugs are sealed in a cylindrical reservoir with a separation membrane. Electrokinetic forces are then utilized to drive ionic drug molecules from the hydrogels into surrounding bulk solutions. The drug release profiles of a model drug show that release rates from the device can be electrically controlled by adjusting the stimulated voltage. When a square voltage wave is applied, the device can be quickly switched between on and off to achieve pulsatile release. The drug dose released is then determined by the duration and amplitude of the applied voltages. In addition, successive on/off cycles can be programmed in the voltage waveforms to generate consistent and repeatable drug release pulses for on-demand drug delivery. V C 2015 AIP Publishing LLC.

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“…[1][2][3][4][5][6][7][8][9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multimodal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI).…”

mentioning

confidence: 99%

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

et al. 2008

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Keywords biological imaging; cancer; drug delivery; magnetic nanoparticles; micelle; quantum dots Multifunctional nanoparticles have the potential to integrate therapeutic and diagnostic functions into a single nanodevice. [1][2][3][4][5][6][7][8][9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multimodal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI). [10][11][12][13][14][15] While these nanocomposites have been used for in vitro magnetic cell separation and in vitro cell targeting, there are limited in vivo studies, particularly for cancer imaging and therapy, due to poor stability or short systemic circulation times generally observed for these more complicated nanostructures. [16,17] Herein, we introduce long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single

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Remotely Triggered Release from Magnetic Nanoparticles

Cited by 259 publications

References 28 publications

Applications of Nanoparticles in Biology

Applications of Nanoparticles in Biology

Programmable and on-demand drug release using electrical stimulation

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

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