Remote sensing of chemical agents within nuclear facilities using Raman spectroscopy

Foster, Michael J.; Wharton, Michael; Brooks, William; Goundry, Matthew; Warren, Charles H.; Storey, Jonathan

doi:10.1002/jrs.6016

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…The light is then fibre coupled into the spectrometer where the spectral information is extracted. The SHS spectrometer design ensures no light is lost despite the large etendue requirements [11].…”

Section: Experimental/instrument Developmentmentioning

confidence: 99%

Demonstration of a compact deep UV Raman spatial heterodyne spectrometer for biologics analysis

Foster

Brooks

Jahn

et al. 2022

Journal of Biophotonics

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Monoclonal antibodies and antibody fragments are increasingly important classes of biotherapeutics. However, these products are both challenging and expensive to manufacture. New process analytical technologies used to monitor these products during their manufacture are of significant interest. Deep UV Raman spectroscopy promises to provide the required specificity and accuracy, however instruments, have historically been large and complex. In this paper, a new deep UV Raman instrument is described using a solid-state laser and a spatial heterodyne spectrometer. The instrument overcomes practical limitations of the technique and could readily be used for online measurement. A series of observations have been made of biopharmaceutical products, including immunoglobulin G and domain antibodies. Where high levels of both specificity and linearity when measuring samples of different concentration with a precision of better than 0.05 mg/mL has been demonstrated.

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Section: Experimental/instrument Developmentmentioning

confidence: 99%

Demonstration of a compact deep UV Raman spatial heterodyne spectrometer for biologics analysis

Foster

Brooks

Jahn

et al. 2022

Journal of Biophotonics

Self Cite

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RaSpectLoc: RAman SPECTroscopy-dependent robot LOCalisation

Thirgood,

Mendez,

Ling

et al. 2023

2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)

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Dual-wavelength wide area illumination Raman difference spectroscopy for remote detection of chemicals

Tian

Hu³

et al. 2021

Appl. Opt.

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Remote Raman instruments have become powerful analytical tools in some special environments. However, ambient daylight is the main limitation in the data acquisition process. To suppress daylight background interference and obtain a high signal-to-background ratio (SBR), we develop a dual-wavelength wide area illumination Raman difference spectroscopy (WAIRDS) system for daytime remote detection. In the WAIRDS system, a wide area illumination scheme and shifted-excitation Raman difference spectroscopy method are used to improve the reliability of collected Raman spectra. Measurements of polystyrene indicate that the WAIRDS system can be operated to obtain background-free Raman spectra under different levels of daylight background interference. The remote results show that the improvement in SBR is about three- to fivefold, and the system can work at distances of up to 9.2 m on a sunny afternoon. Moreover, to be close to the actual detection, the system is used for mineral and explosive raw material detection during daytime measurement. Measurements show that the WAIRDS system will be a useful tool for many remote applications in the future.

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Remote sensing of chemical agents within nuclear facilities using Raman spectroscopy

Cited by 3 publications

References 25 publications

Demonstration of a compact deep UV Raman spatial heterodyne spectrometer for biologics analysis

Demonstration of a compact deep UV Raman spatial heterodyne spectrometer for biologics analysis

RaSpectLoc: RAman SPECTroscopy-dependent robot LOCalisation

Dual-wavelength wide area illumination Raman difference spectroscopy for remote detection of chemicals

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