COVID-19 has placed excessive psychological and moral stress and work demands on patients, clinicians, health care organizations, and society. COVID-19 also advanced patient safety in an unexpected way. Before the COVID-19 pandemic, patient monitoring for harm and many approaches to prevent harm were linked to where the patient was treated in the hospital.A report based on data prior to the COVID-19 pandemic suggested that routinely monitoring hospitalized patients with continuous pulse oximetry and heart rate devices was associated with reduced mortality. 1 In that study, which involved 126 697 patient discharges between 2007 and 2017, early recognition of hypoxemia and respiratory depression were largely responsible for the observed decrease in mortality, from 0 deaths among 111 487 patients in monitored units vs 3 deaths among 15 209 patients in unmonitored units. Yet this surveillance system was not broadly adopted, and monitoring remains linked to location in the hospital. COVID-19 created a need to monitor patients treated in standard medical units, in emergency departments (EDs), and to also monitor some patients at home for clinical deterioration (eg, hypoxemia) to help increase hospital capacity. With the increased volume of patients coupled with high staffing ratios for all types of clinician workload, hospitalized patients are at increased risk for unrecognized clinical deterioration.Thus, patient risk, rather than physical location, should dictate the degree of monitoring. Many patients treated in general medical and surgical units and patients with COVID-19 treated at home would benefit from continuous pulse oximetry. Some individuals with COVID-19 may have died at home from unrecognized hypoxemia. A 2021 excess mortality modeling analysis estimated an additional 24% of unrecognized COVID-19attributable deaths. 2 The pandemic accelerated the move to monitoring and therapy based on patient risks and needs. A combination of medical urgency, technology advances, and payment policy supported this change. Despite many health systems reporting expanded use of monitoring, there is limited evidence regarding the incidence and prevalence of hospital unit and home monitoring, the safety and efficacy of hospital and home monitoring, and the types of patients who most benefit from which type of therapy.This Viewpoint reviews the benefits of remote monitoring in the hospital and home settings, explores the technology advances that made it possible, describes the Centers for Medicare & Medicaid Services (CMS) payment policy changes that made home monitoring sustainable, and discusses what health systems could do to launch and publish a home monitoring program.