Remote, highly automated operations and maintenance tools (O&M) are crucial for economically successful deployment of molten salt reactors (MSRs). Liquid-fueled MSRs will have high dose rates within containment following initial start-up due to the proximity of the fuel salt and gaseous fission products. The challenges of performing O&M in high dose environments have long been recognized, and many of the required technology components have been developed for use in similar high radiation environments.To be competitive, future MSRs need to have much lower labor costs than existing nuclear power plants. The advance of digital technologies provides the opportunity to automate maintenance activities. Advances in modeling and simulation (M&S) may enable the role of the operator to be shifted from remote task performance to oversight of automated systems. Dynamically updating a plant's digital twin representation through integrating multiple sensor signals will be key to automating complex process tasks. Since complex, highly automated maintenance in high radiation areas has not been proven, adequate demonstration is required to validate its performance.