Remote Ischemic Preconditioning Fails to Improve Early Renal Function of Patients Undergoing Living-Donor Renal Transplantation

Chen, Ye-ling; Zheng, Hua; Wang, Xueren; Zhou, Zhiqiang; Luo, Ai-lun; Tian, Yuan

doi:10.1097/tp.0b013e3182782f3a

Cited by 49 publications

(48 citation statements)

References 14 publications

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“…rIPC, consisting of three 5-minute cycles of leg ischemia and 5 minutes of reperfusion in donors or recipients, failed to improve early renal function in patients receiving living-donor renal transplantation. 76 One possible explanation for inefficiency of the procedure might be a unilaterally performed rIPC stimulus in donors or recipients. Conversely, simultaneously applying rIPC in both donors and recipients may yield different results and should be addressed in future trials in solid organ transplantation.…”

mentioning

confidence: 99%

Remote Ischemic Preconditioning and Renoprotection

Gassanov¹,

Nia

Caglayan³

et al. 2014

Journal of the American Society of Nephrology

118

106

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There is currently no effective prophylactic regimen available to prevent contrastinduced AKI (CI-AKI), a frequent and life-threatening complication after cardiac catheterization. Therefore, novel treatment strategies are required to decrease CI-AKI incidence and to improve clinical outcomes in these patients. Remote ischemic preconditioning (rIPC), defined as transient brief episodes of ischemia at a remote site before a subsequent prolonged ischemia/reperfusion injury of the target organ, is an adaptational response that protects against ischemic and reperfusion insult. Indeed, several studies demonstrated the tissue-protective effects of rIPC in various target organs, including the kidneys. In this regard, rIPC may offer a novel noninvasive and virtually cost-free treatment strategy for decreasing CI-AKI incidence. This review evaluates the current experimental and clinical evidence for rIPC as a potential renoprotective strategy, and discusses the underlying mechanisms and key areas for future research.

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mentioning

confidence: 99%

Remote Ischemic Preconditioning and Renoprotection

Gassanov¹,

Nia

Caglayan³

et al. 2014

Journal of the American Society of Nephrology

118

106

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“…Limb ischemia-induced RIPC has been shown to reduce cardiac and renal IRI in humans (31,32,37). In a recent pilot study, use of hind-limb ischemia in either donors or in recipients to induce RIPC during living-donor kidney transplantation yielded no beneficial effects (45). Our own clinical trials of lower limb ischemia-induced remote preconditioning in brain death donors (NCT0097572 and NCT01515072) are in progress.…”

Section: Discussionmentioning

confidence: 97%

Does Liver Ischemic Preconditioning in Brain Death Donors Induce Kidney Preconditioning? A Retrospective Analysis

Desai

Mora-Esteves²,

Holland³

et al. 2014

Transplantation

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“…In 2013, Chen et al conducted the first clinical study testing remote preconditioning, with a protocol of three 5-min cycles with a blood pressure cuff encircling the leg, in 60 patients receiving living-donor renal transplant [43]. The RIPC protocol was administered either to the donor or recipient of the organ.…”

Section: Solid Organ Transplantationmentioning

confidence: 99%

Remote ischemic conditioning: Current clinical perspectives

Page

Prunier

2015

Journal of Cardiology

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Remote ischemic conditioning (RIC) constitutes a promising method in which a tissue or organ is exposed to intermittent ischemia/reperfusion periods enabling it to provide protection to a distant target organ. RIC has been tested in various clinical settings through its simple application by means of intermittent inflation of a blood pressure cuff placed on a limb, primarily evaluating its potential abilities to decrease myocardial injury biomarkers. Its use on other organs, such as the kidneys or brain, has recently been a topic of research. To date, no study has yet been powerful enough to reach a conclusion on the potential benefit of RIC on clinical outcomes. The future role of RIC in the clinical arena could be clarified by the large phase III trials currently underway targeting major outcomes as primary endpoints.

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Remote Ischemic Preconditioning Fails to Improve Early Renal Function of Patients Undergoing Living-Donor Renal Transplantation

Cited by 49 publications

References 14 publications

Remote Ischemic Preconditioning and Renoprotection

Remote Ischemic Preconditioning and Renoprotection

Does Liver Ischemic Preconditioning in Brain Death Donors Induce Kidney Preconditioning? A Retrospective Analysis

Remote ischemic conditioning: Current clinical perspectives

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