Remote ischemic preconditioning and outcome

Zarbock, Alexander; Aken, Hugo Van; Schmidt, Christoph

doi:10.1097/aco.0000000000000161

Cited by 9 publications

(2 citation statements)

References 66 publications

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“…In this study, a single tourniquet inflation cycle was performed for five minutes that showed to be sufficient to obtain analgesic effects. Zarbock et al [ 24 ] in a recent publication are questioning the need for intermittent tourniquet.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Experimental Model to Evaluate Analgesic Effect of Remote Ischemic Preconditioning in Acute Postoperative Pain

Pereira

Mello

Pimenta

et al. 2016

Pain Research and Treatment

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This study aims to evaluate the viability of a clinical model of remote ischemic preconditioning (RIPC) and its analgesic effects. It is a prospective study with twenty (20) patients randomly divided into two groups: control group and RIPC group. The opioid analgesics consumption in the postoperative period, the presence of secondary mechanical hyperalgesia, the scores of postoperative pain by visual analog scale, and the plasma levels interleukins (IL-6) were evaluated. The tourniquet applying after spinal anesthetic block was safe, producing no pain for all patients in the tourniquet group. The total dose of morphine consumption in 24 hours was significantly lower in RIPC group than in the control group (p = 0.0156). The intensity analysis of rest pain, pain during coughing and pain in deep breathing, showed that visual analogue scale (VAS) scores were significantly lower in RIPC group compared to the control group: p = 0.0087, 0.0119, and 0.0015, respectively. There were no differences between groups in the analysis of presence or absence of mechanical hyperalgesia (p = 0.0704) and in the serum levels of IL-6 dosage over time (p < 0.0001). This clinical model of remote ischemic preconditioning promoted satisfactory analgesia in patients undergoing conventional cholecystectomy, without changing serum levels of IL-6.

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Section: Discussionmentioning

confidence: 99%

A Clinical Experimental Model to Evaluate Analgesic Effect of Remote Ischemic Preconditioning in Acute Postoperative Pain

Pereira

Mello

Pimenta

et al. 2016

Pain Research and Treatment

View full text Add to dashboard Cite

show abstract

“…21 In the study by Zarbock et al, 10 RIPC increased urinary high mobility group box (HMGB) 1, an endogenous factor that mediates activation of the innate immune response including chemotaxis and proinflammatory cytokine release. For cardiac protection, transient limb ischemia releases a low-molecular-weight (<15-kDa) factor that protects the myocardium against ischemia/reperfusion injury in a mechanism that requires opioid-receptor activation and modification of mitochondrial function via ATP-sensitive potassium channels.…”

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confidence: 99%