Remote Ischemic Conditioning to Improve Splanchnic Perfusion and Prevent Necrotizing Enterocolitis in Premature Piglets

Abstract

SK-N-FI NS1 (MYCN-nonamplified/high HRAS expression) cells had decreased RAS activity after NS1 induction with doxycycline (Figs. 1A, 1B). SK-N-FI NS1 tumor-bearing mice that received doxycycline had delayed tumor formation (Fig. 1C) and growth (Fig. 1D). Patients with elevated H-RAS expression neuroblastoma tumors have worse overall survival (Fig. 1E). GSEA identified top enriched gene sets (Fig. 1F) and upregulated genes (Figs. 1G, 1H) in MYCN-non-amplified/high H-RAS human neuroblastoma tumors.