Remote fiber-optic biosensors based on evanescent-excited fluoro-immunoassay: Concept and progress

Andrade, Joseph D.; VanWagenen, R.A.; Gregonis, D. E.; Newby, K.; Lin, Jinn-Nan

doi:10.1109/t-ed.1985.22096

Cited by 157 publications

(38 citation statements)

References 3 publications

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“…Using this light tapping scheme, we experimentally demonstrated, for the first time, efficient and distributive laser-ultrasound generation at multiple locations along a fiber in a controllable manner, which may find attractive applications in all-fiber and embedded ultrasonic testing system for structural health monitoring. The proposed light tapping method can also find applications in remote fiber device actuation [16] and distributed biochemical sensing [17].…”

Section: Resultsmentioning

confidence: 99%

Distributed fiber-optic laser-ultrasound generation based on ghost-mode of tilted fiber Bragg gratings

Tian¹,

Zhang²,

Han³

2013

Opt. Express

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Active ultrasonic testing is widely used for medical diagnosis, material characterization and structural health monitoring. Ultrasonic transducer is a key component in active ultrasonic testing. Due to their many advantages such as small size, light weight, and immunity to electromagnetic interference, fiber-optic ultrasonic transducers are particularly attractive for permanent, embedded applications in active ultrasonic testing for structural health monitoring. However, current fiberoptic transducers only allow effective ultrasound generation at a single location of the fiber end. Here we demonstrate a fiber-optic device that can effectively generate ultrasound at multiple, selected locations along a fiber in a controllable manner based on a smart light tapping scheme that only taps out the light of a particular wavelength for laser-ultrasound generation and allow light of longer wavelengths pass by without loss. Such a scheme may also find applications in remote fiber-optic device tuning and quasidistributed biochemical fiber-optic sensing. 1175-1179 (1985).

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Section: Resultsmentioning

confidence: 99%

Distributed fiber-optic laser-ultrasound generation based on ghost-mode of tilted fiber Bragg gratings

Tian¹,

Zhang²,

Han³

2013

Opt. Express

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“…(Carniglia et al, 1972) Harrick and Loeb first applied the principle of back-coupled fluorescence using an ATR element to detect a fluorescently labeled self-assembled thin-film of bovine serum albumin. Fiber optic based back-coupled fluorescence biosensors were first presented by Andrade et al in 1985 and theoretically explored by Glass et al and Marcuse. Fig.…”

Section: Mechanism Of Back-coupled Fluorescencementioning

confidence: 99%

Applications of the Planar Fiber Optic Chip

Beam¹,

Burnett²,

Webster³

et al. 2012

Recent Progress in Optical Fiber Research

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“…a chemical solution) flowed over the sensing surface, or for monitoring the formation of a thin film on the sensing surface, for example, the binding of an analyte to immobilised antibodies [6]. The resulting changes in effective index can be observed as a change in phase, amplitude, in-or out-coupling angle or wavelength depending on the type of sensor [3][4][5][6][7][8].…”

Section: Sensing Using Dfb Lasersmentioning

confidence: 99%

“…The evanescent field of a guided wave is highly sensitive to refractive index changes at the surface of a waveguide, so can be used to detect very small changes in the refractive index and thickness of a surface layer. Techniques often used in biochemical research include fibre-optic chemical sensing [3], surface plasmon resonance [4] and dual-polarisation interferometry [5]. The latter two may be implemented as a label-free system, that is, not requiring the use of fluorescent dyes, as is the case with many optical biosensing systems.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of distributed feedback laser biosensors

Coote

Reddy

Sweeney

2007

IET Optoelectronics

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A new integrated optical sensor chip is proposed, based on a modified distributedfeedback (DFB) semiconductor laser. The semiconductor layers of different refractive indices that comprise a laser form the basis of a waveguide sensor, where changes in the refractive index of material at the surface are sensed via changes in the evanescent field of the lasing mode. In DFB lasers, laser oscillation occurs at the Bragg wavelength. Since this is sensitive to the effective refractive index of the optical mode, the emission wavelength is sensitive to the index of a sample on the waveguide surface. Hence, lasers are modelled as planar waveguides and the effective index of the fundamental transverse electric mode is calculated as a function of index and thickness of a thin surface layer using the beam propagation method. We find that an optimised structure has a thin upper cladding layer of 0.15 mm, which according to this model gives detection limits on test layer index and thickness resolution of 0.1 and 1.57 nm, respectively, a figure which may be further improved using two lasers in an interferometer-type configuration.

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Remote fiber-optic biosensors based on evanescent-excited fluoro-immunoassay: Concept and progress

Cited by 157 publications

References 3 publications

Distributed fiber-optic laser-ultrasound generation based on ghost-mode of tilted fiber Bragg gratings

Distributed fiber-optic laser-ultrasound generation based on ghost-mode of tilted fiber Bragg gratings

Applications of the Planar Fiber Optic Chip

Optimisation of distributed feedback laser biosensors

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