Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid

Reed, Rebecca G.; Hillmann, Abby R.; Nation, Maegan; Braksator, Shay; Sigler, Kirby

doi:10.1016/j.bbi.2024.07.001

Brain, Behavior, and Immunity

2024

DOI: 10.1016/j.bbi.2024.07.001

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Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid

Rebecca G. Reed,

Abby R. Hillmann,

Maegan Nation

et al.

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2024

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Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review

Kurbatfinski,

Dosani,

Dewey

et al. 2024

Children

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Adverse childhood experiences (ACEs; e.g., physical abuse) can impact lifelong mental health both directly and intergenerationally, with effects transmitted from the parent to the child. Several physiological mechanisms have been proposed to explain the impacts of ACEs on mental health. The purpose of this narrative review was to synthesize and critique the peer-reviewed literature on physiological mechanisms proposed to underlie the impacts of ACEs on mental health, specifically: (1) hypothalamic–pituitary–adrenal axis functioning, (2) inflammation, (3) genetic inheritance and differential susceptibility, (4) epigenetics, (5) brain structure and function, (6) oxidative stress, and (7) metabolic profiles. We searched Google Scholar using variations of the terms “adverse childhood experiences”, “mechanisms”, and “mental health” to locate relevant peer-reviewed literature. We also mined citations of the identified literature to find additional important sources. The role of inflammation in the etiology of mental health conditions among those exposed to ACEs appeared promising, followed by hypothalamic–pituitary–adrenal axis functioning, brain structure and function, genetics, epigenetics, metabolism, and lastly, oxidative stress. Replication studies that examine the associations among ACEs, genetic inheritance and differential susceptibility, epigenetics, oxidative stress, and metabolism are required to better define links with mental health.

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Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review

Kurbatfinski,

Dosani,

Dewey

et al. 2024

Children

View full text Add to dashboard Cite

show abstract

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Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid

Cited by 1 publication

References 63 publications

Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review

Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review

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