Remote‐Control Photorelease of Caged Compounds Using Near‐Infrared Light and Upconverting Nanoparticles

Carling, Carl-Johan; Nourmohammadian, Farahnaz; Boyer, John‐Christopher; Branda, Neil R.

doi:10.1002/anie.201000611

Cited by 213 publications

(142 citation statements)

References 33 publications

(37 reference statements)

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“…The pulsed excitation approach will greatly increase the applicability of UCNPs not only in diffuse optical imaging but also in many other biomedical applications, such as photodynamic therapy and remote activation of biomolecules in deep tissues. 35,36 It is worth mentioning that metallic nanostructures are reported to be effective in enhancing UC emissions owing to their local field enhancement effect by surface plasmonic coupling. 37 We envisage that the combination of the pulsed excitation approach and metallic nanostructures could become a major scheme of using UCNPs in the diffuse light regime, due to the synergistic effect in increasing the excitation power density.…”

Section: Discussionmentioning

confidence: 99%

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Liu

Dumlupinar

et al. 2013

Nanoscale

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-Engels, S. (2013). Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power. Nanoscale, 5(20), 10034-10040. https://doi.org/10.1039/c3nr01917aRegistered Charity Number 207890 Accepted ManuscriptThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, which is prior to technical editing, formatting and proof reading. This free service from RSC Publishing allows authors to make their results available to the community, in citable form, before publication of the edited article. This Accepted Manuscript will be replaced by the edited and formatted Advance Article as soon as this is available.To cite this manuscript please use its permanent Digital Object Identifier (DOI®), which is identical for all formats of publication.More information about Accepted Manuscripts can be found in the Information for Authors.Please note that technical editing may introduce minor changes to the text and/or graphics contained in the manuscript submitted by the author(s) which may alter content, and that the standard Terms & Conditions and the ethical guidelines that apply to the journal are still applicable. In no event shall the RSC be held responsible for any errors or omissions in these Accepted Manuscript manuscripts or any consequences arising from the use of any information contained in them. We have accomplished deep tissue optical imaging of upconverting nanoparticles at 800 nm, using millisecond single pulse excitation with high peak power. This is achieved by carefully choosing the pulse parameters, derived from time-resolved rateequation analysis, which result in higher intrinsic quantum yield that is utilized by upconverting nanoparticles for generating this near infrared upconversion emission. The pulsed excitation approach thus promises previously unreachable imaging depths and shorter data acquisition times compared with continuous wave excitation, while simultaneously keeping the possible thermal side-effects of the excitation light moderate. These key results facilitate means to break through the general shallow depth limit of upconverting-nanoparticle-based fluorescence techniques, necessary for a range of biomedical applications, including diffuse optical imaging, photodynamic therapy and remote activation of biomolecules in deep tissues. www.rsc.org/nanoscale

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Section: Discussionmentioning

confidence: 99%

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Liu

Dumlupinar

et al. 2013

Nanoscale

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“…In 2010 Carling et al [118] chromophore absorbs only in the UV (λ max = 282 nm), so it is light from the 1 D 2 ⇒ 3 H 6 emission of Tm 3+ at 290 nm that is necessary to trigger this photoreaction, hence the relatively high laser intensity needed. In a more directly biological application Yang et al [119] prepared NaYF 4 :Yb/Tm(20/0.2%)@NaYF 4 core : shell UCNPs (approx.…”

Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia

Zhang

Ford

2013

Phil. Trans. R. Soc. A.

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Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery (‘uncaging’) of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.

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“…These upconversion nanoparticles are usually made of host lattices of ceramic materials, such as LaF 3 , YF 3 , Y 2 O 3 , LaPO 4 , NaYF 4 embedded with trivalent lanthanide ions like Yb 3þ , Er 3þ , and Tm 3þ and show a unique phenomenon of absorbing NIR light and emitting UV, visible, and NIR light (10). There are a few reports exploiting NIR-to-NIR and NIRto-visible upconversion nanoparticles (UCNs) (11)(12)(13)(14); however, the use of NIR-to-UV UCNs is minimally explored (15)(16)(17).…”

mentioning

confidence: 99%

Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers

Jayakumar

Idris

Zhang

2012

Proc. Natl. Acad. Sci. U.S.A.

343

255

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Controlled activation or release of biomolecules is very crucial in various biological applications. Controlling the activity of biomolecules have been attempted by various means and controlling the activity by light has gained popularity in the past decade. The major hurdle in this process is that photoactivable compounds mostly respond to UV radiation and not to visible or near-infrared (NIR) light. The use of UV irradiation is limited by its toxicity and very low tissue penetration power. In this study, we report the exploitation of the potential of NIR-to-UV upconversion nanoparticles (UCNs), which act as nanotransducers to absorb NIR light having high tissue penetration power and negligible phototoxicity and emit UV light locally, for photoactivation of caged compounds and, in particular, used for photo-controlled gene expression. Both activation and knockdown of GFP was performed in both solution and cells, and patterned activation of GFP was achieved successfully by using upconverted UV light produced by NIR-to-UV UCNs. In-depth photoactivation through tissue phantoms and in vivo activation of caged nucleic acids were also accomplished. The success of this methodology has defined a unique level in the field of photo-controlled activation and delivery of molecules.

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Remote‐Control Photorelease of Caged Compounds Using Near‐Infrared Light and Upconverting Nanoparticles

Cited by 213 publications

References 33 publications

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers

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