Remote Control of Neural Stem Cell Fate Using NIR-Responsive Photoswitching Upconversion Nanoparticle Constructs

Zhang, Yixiao; Wiesholler, Lisa M.; Rabie, Hudifah; Jiang, Pengfei; Lai, Jinping; Hirsch, Thomas; Lee, Ki‐Bum

doi:10.1021/acsami.0c10145

Cited by 16 publications

(14 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,7 To overcome such limitations, up-conversion nanoparticles (UCNPs) represent an attractive alternative owing to their ability to transform near-infrared light (NIR) into visible light, because NIR light possesses high tissue penetration, low autouorescence, and low scattering, facilitating their application in remote control of numerous physiological functions in living organisms without invasive procedures or signicant phototoxicity. [8][9][10] However, their low up-conversion emission efficiency (<9%) restricts their full potential. 2,7,9,11 To overcome this disadvantage, great efforts have been made, including the use of different host matrices, such as single crystals, glasses, and glass-ceramic materials.…”

Section: Introductionmentioning

confidence: 99%

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[ 198 ] Similar results could be expected in cell culture experiments and have been used specifically with neural cells to dictate neural differentiation of induced pluripotent stem cells in vitro utilizing an 808 nm laser‐activated conformational change in the shell resulting in the release of retinoic acid from the particle. [ 199 ]…”

Section: Bioimaging In Live Cellsmentioning

confidence: 99%

Bioimaging with Upconversion Nanoparticles

Mettenbrink

Yang

Wilhelm

2022

Advanced Photonics Research

View full text Add to dashboard Cite

Bioimaging enables the spatiotemporal visualization of biological processes at various scales empowered by a range of different imaging modalities and contrast agents. Upconversion nanoparticles (UCNPs) represent a distinct type of such contrast agents with the potential to transform bioimaging due to their unique optical properties and functional design flexibilities. This review explores and discusses the opportunities, challenges, and limitations that UCNPs exhibit as bioimaging probes and highlights applications with spatial dimensions ranging from the single nanoparticle level to cellular, tissue, and whole animal imaging. Recent advancements in bioimaging applications enabled by UCNPs, including super‐resolution techniques and multimodal imaging methods are summarized, and a perspective on the future potential of UCNP‐based technologies in bioimaging research and clinical translation is provided. This review may provide a valuable resource for researchers interested in exploring and applying UCNP‐based bioimaging technologies.

show abstract

“…Topographical regulation with ECM modulation, not only cellular bioengineering, may help facilitate spatiotemporal control of organoid niches, thereby creating next-generation organoids (Figure 11). Light-mediated release of small molecules [200] or light-mediated 3D patterning of bioactive cues [201] was developed to induce guided morphogenesis. Still, there is a critical limitation of currently used materials in that it is hard to understand which properties of each material govern the specific behavior of cells.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

“…Forebrain subdivisions that contain positional axes [22] Dual patterning from bipotent progenitors Self-organizing neuromuscular organoids [197] Stepwise modulation of signaling cues Cerebrospinal fluid production of choroid plexus-forming brain organoids [198] Stepwise modulation of signaling cues Hair-bearing skin organoids [199] Interorganoid communication Assembly of region-specific models Mixed dorsal and ventral forebrain organoids [54] Co-culture with connective tissue Promoted formation of alveolar organoid by addition of mesenchymal stem cells [213] Co-culture with connective tissue/organ-on-a-chip Structural arrangement in mesenchymal bodies [214] Organ-on-a-chip Recapitulating the connections between GI microbiome and CNS [207] Organ-on-a-chip/bioprinting Multi-organ interactions upon drug administration [208] Bioprinting Self-patterned 3D tissue models [209] Topographical patterning/profiling Light-induced small molecule release Spatiotemporally controlled neural stem cell fate [200] Light-induced patterning Axon guidance with NGF-patterned matrix [201] AI-based optimization Predicted experimental parameters for PSC self-organization [202] Microrheological characterization Mechanical properties of collagen gels and cell ECM interactions [203] Super-resolution imaging Cellular composition of organoids with high resolution 3D imaging [216] Spatial transcriptomics Visualization of the distribution of mRNAs [215] Spatial proteomics Spatiotemporal profiling of signaling interactomes [217] understood how to suppress the chaotic differentiation of mesenchymal stem cells and implement connective tissues with diverse composition and characteristics in the body. Advancements in analytical methods, for instance, single-cell sequencing, enable researchers to decipher the transcriptional profile of cell populations that compose organoids or the connective tissues at the single-cell level.…”

Section: Intraorganoid Specification Signaling Protein (Shh) Gradient With Genome Engineeringmentioning

confidence: 99%

Bioengineering Approaches for the Advanced Organoid Research

Zhang

Rathnam

et al. 2021

Advanced Materials

Self Cite

View full text Add to dashboard Cite

organoids should exhibit essential features, including organ-specific multiple cell types, functions of the organ, and spatially organized structures. The emergence and progression of organoid technologies have resulted from several important discoveries (Figure 1). The formation of actual tissuelike colonies in vitro was firstly observed from a co-culture system of keratinocytes and 3T3 fibroblasts. [4] Self-organization, one of the fundamental aspects of organogenesis, was first observed via two distinct approaches, namely reaggregation and structural patterning of dissociated single cells. [5,6] The establishment of 3D culture methods for the structural organization began with the development of extracellular matrices (ECM).In the late 1980s, Bissell and colleagues observed that a laminin-rich gel could function as a basement membrane to differentiate and morphogenesis of mammary epithelial cells. [7,8] In the 1990s, it was reported that in addition to their primary role in physical support, ECM components could regulate gene expression by interacting with integrin-based focal adhesion pathways. [9] Finally, in 2009, Clevers group reported that embedding single intestinal stem cells in ECM substitute had created crypt-like structures similar to the epithelium of the native intestinal tissues, which were the first organoids. [10] Based on these recognitions, biochemical cues that include the initiation of lineage-specific genetic programs have been incorporated in 3D organoid cultures. Through exposure to morphogens, growth factors, or morphogen inhibitors, multiple research groups rapidly developed various organoid models using embryonic stem cells (ESCs) or adult stem cells (ASCs); these include intestine, [10] stomach, [11] liver, [12] pancreas, [13] prostate, [14] and brain [15] organoids. At the same time, vascularization techniques were devised by several groups to embody microenvironments that are physiologically close to their actual counterparts. Microfluidic systems, [16] endothelial cell-coated modules, [17] and vascular endothelial growth factor delivery systems [18] have been demonstrated as in vitro vasculature systems that can facilitate oxygen or nutrients transport to the inner mass of organoids.In the late 2010s, owing to the accumulated information on mechanisms underlying organogenesis and the remarkable advancements in the fields of biomaterial and bioengineering, the era of "organoid customization" has begun. Customizable hydrogel matrices have been proposed to form intestinal organoids whose internal networks recapitulate the Recent advances in 3D cell culture technology have enabled scientists to generate stem cell derived organoids that recapitulate the structural and functional characteristics of native organs. Current organoid technologies have been striding toward identifying the essential factors for controlling the processes involved in organoid development, including physical cues and biochemical signaling. There is a growing demand for engineering dynamic niches characterized by ...

show abstract

Remote Control of Neural Stem Cell Fate Using NIR-Responsive Photoswitching Upconversion Nanoparticle Constructs

Cited by 16 publications

References 69 publications

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

Highly efficient green up-conversion emission from fluoroindate glass nanoparticles functionalized with a biocompatible polymer

Bioimaging with Upconversion Nanoparticles

Bioengineering Approaches for the Advanced Organoid Research

Contact Info

Product

Resources

About