Remote control of cellular immunotherapy

Huang, Kai; Liu, Longwei; Huang, Yun; Wang, Yingxiao; Zhou, Yubin; Han, Gang

doi:10.1038/s44222-023-00042-8

Cited by 6 publications

(4 citation statements)

References 227 publications

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“… 165 , 166 , 268 – 272 Rev. 20 , 68 , 99 , 263 , 273 – 275 Switch CAR a Small molecules/physical stimulations control CAR activity via inducible assembly or stabilization (+) CAR activity can be precisely spatiotemporally controlled (+) Perform safety control (+) Prevent on-target off-tumor toxicity Res. 169 , 171 , 172 , 220 , 276 – 281 Rev.…”

Section: Diverse Types Of Synthetic Receptorsmentioning

confidence: 99%

“… 20 , 197 a Here we narrowly describe switch CAR systems built via solely engineered CAR architecture. Broadly speaking, switch CAR systems can also be constructed via induced transcription expression for CAR expression, like synNotch CAR and TetOn-induced CAR 68 , 101 , 275 , 329 b Here we describe switchable CAR systems as a unique CAR T cell can be redirected to target a new antigen by adding a bispecific adaptor protein. And in this sense, SUPRA CARs also belong to these systems c The ScFv-EpoR D1D2 -cytokine receptor chimera should be considered as the prototype of the GEMS platform d Constitutively active ErbB rather than transiently activated ErbB induces RASER proteins to release a programmable effector + and − represent advantages and disadvantages, respectively.…”

Section: Diverse Types Of Synthetic Receptorsmentioning

confidence: 99%

“…a Here we narrowly describe switch CAR systems built via solely engineered CAR architecture. Broadly speaking, switch CAR systems can also be constructed via induced transcription expression for CAR expression, like synNotch CAR and TetOn-induced CAR 68 , 101 , 275 , 329 …”

Section: Diverse Types Of Synthetic Receptorsmentioning

confidence: 99%

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Programmable synthetic receptors: the next-generation of cell and gene therapies

Teng,

Cui,

Zhou

et al. 2024

Sig Transduct Target Ther

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Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy require to be further addressed in order to realize their full potential. Synthetic receptors, a synthetic biology tool that can precisely control the function of therapeutic cells and genetic modules, have been rapidly developed and applied as a powerful solution. Delicately designed and engineered, they can be applied to finetune the therapeutic activities, i.e., to regulate production of dosed, bioactive payloads by sensing and processing user-defined signals or biomarkers. This review provides an overview of diverse synthetic receptor systems being used to reprogram therapeutic cells and their wide applications in biomedical research. With a special focus on four synthetic receptor systems at the forefront, including chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors, we address the generalized strategies to design, construct and improve synthetic receptors. Meanwhile, we also highlight the expanding landscape of therapeutic applications of the synthetic receptor systems as well as current challenges in their clinical translation.

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Section: Diverse Types Of Synthetic Receptorsmentioning

confidence: 99%

Section: Diverse Types Of Synthetic Receptorsmentioning

confidence: 99%

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Programmable synthetic receptors: the next-generation of cell and gene therapies

Teng,

Cui,

Zhou

et al. 2024

Sig Transduct Target Ther

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“…Photonic upconversion materials convert low-energy photons into high-energy photons . Due to their extraordinary optical characteristics, upconversion materials have attracted wide interest, including biosensing, , optogenetics, tumor immunotherapy, , etc. In particular, organic molecules-based triplet–triplet annihilation upconversion (TTA-UC) with high upconversion quantum efficiency (η UC ), low excitation power density (∼20 mW/cm 2 ), and tunable excitation/emission wavelength has become a new generation of upconversion materials. − TTA-UC is composed of a photosensitizer and an annihilator.…”

Section: Introductionmentioning

confidence: 99%

Natural Protein Photon Upconversion Supramolecular Assemblies for Background-Free Biosensing

Feng,

Zeng,

et al. 2024

J. Am. Chem. Soc.

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The diagnosis of disease biomarkers is crucial for the identification, monitoring, and prognostic assessment of malignant disease. However, biological samples with autofluorescence, complex components, and heterogeneity pose major challenges to reliable biosensing. Here, we report the self-assembly of natural proteins and the triplet−triplet annihilation upconversion (TTA-UC) pair to form upconverted protein clusters (∼8.2 ± 1.1 nm), which were further assembled into photon upconversion supramolecular assemblies (PUSA). This PUSA exhibited unique features, including a small size (∼44.1 ± 4.1 nm), oxygen tolerance, superior biocompatibility, and easy storage via lyophilization, all of which are long sought after for photon upconversion materials. Further, we have revealed that the steric hindrance of the annihilator suppresses the stacking of the annihilator in PUSA, which is vital for maintaining the water dispersibility and enhancing the upconversion performance of PUSA. In conjunction with sarcosine oxidase, this near infrared (NIR)-excitable PUSA nanoprobe could perform background-free biosensing of urinary sarcosine, which is a common biomarker for prostatic carcinoma (PCa). More importantly, this nanoprobe not only allows for qualitative identification of urinary samples from PCa patients by the unaided eye under NIR-light-emitting diode (LED) illumination but also quantifies the concentration of urinary sarcosine. These remarkable findings have propelled photon upconversion materials to a new evolutionary stage and expedited the progress of upconversion biosensing in clinical diagnostics.

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Progress on Electro‐Enhancement of Cell Manufacturing

Tian,

Tay

2023

Small Methods

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With the long persistence of complex, chronic diseases in society, there is increasing motivation to develop cells as living medicine to treat diseases ranging from cancer to wounds. While cell therapies can significantly impact healthcare, the shortage of starter cells meant that considerable raw materials must be channeled solely for cell expansion, leading to expensive products with long manufacturing time which can prevent accessibility by patients who either cannot afford the treatment or have highly aggressive diseases and cannot wait that long. Over the last three decades, there has been increasing knowledge on the effects of electrical modulation on proliferation, but to the best of the knowledge, none of these studies went beyond how electro‐control of cell proliferation may be extended to enhance industrial scale cell manufacturing. Here, this review is started by discussing the importance of maximizing cell yield during manufacturing before comparing strategies spanning biomolecular/chemical/physical to modulate cell proliferation. Next, the authors describe how factors governing invasive and non‐invasive electrical stimulation (ES) including capacitive coupling electric field may be modified to boost cell manufacturing. This review concludes by describing what needs to be urgently performed to bridge the gap between academic investigation of ES to industrial applications.

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Remote control of cellular immunotherapy

Cited by 6 publications

References 227 publications

Programmable synthetic receptors: the next-generation of cell and gene therapies

Programmable synthetic receptors: the next-generation of cell and gene therapies

Natural Protein Photon Upconversion Supramolecular Assemblies for Background-Free Biosensing

Progress on Electro‐Enhancement of Cell Manufacturing

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