“…For example, Dulko et al describe the creation of a toolset that can be used to deploy a decentralized trial, which they refer to as a “clinical-trial-in-a-box” [ 8 ]. Similarly, Cafaro et al describe their approach to conducting a single center trial in a decentralized manner, and through their report are making public the tools they developed to support trial activities [ 9 ]. Two large, decentralized trials, COVID-OUT and ACTIV-6, have provided critical evidence about the effectiveness of repurposed medications in keeping patients with SARS-CoV-2 infection out of the hospital and helping them feel better faster [ 10 ].…”