Remote and Self‐Induced Release from Polyelectrolyte Multilayer Capsules and Films

Skirtach, André G.; Volodkin, Dmitry; Möhwald, Helmuth

doi:10.1002/9783527646746.ch39

Cited by 2 publications

(2 citation statements)

References 190 publications

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“…The aforementioned vaterite CaCO 3 crystals are widely used as sacrificial cores for the fabrication of PEMCs [ 37 , 38 , 39 ] as well as larger tailor-made polymer based structures like porous polymer scaffolds [ 40 , 41 , 42 , 43 ]. The vaterite polymorph belongs to a family of naturally derived minerals [ 44 ], but can be readily produced from low-cost precursor salts (e.g., sodium carbonate and calcium chloride) at either the micro- or nanoscale [ 45 , 46 ].…”

Section: The Development Of Polyelectrolyte Multilayer Capsules (Pmentioning

confidence: 99%

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

2020

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Polyelectrolyte multilayer capsules (PEMCs) templated onto biocompatible and easily degradable vaterite CaCO3 crystals via the layer-by-layer (LbL) polymer deposition process have served as multifunctional and tailor-made vehicles for advanced drug delivery. Since the last two decades, the PEMCs were utilized for effective encapsulation and controlled release of bioactive macromolecules (proteins, nucleic acids, etc.). However, their capacity to host low-molecular-weight (LMW) drugs (<1–2 kDa) has been demonstrated rather recently due to a limited retention ability of multilayers to small molecules. The safe and controlled delivery of LMW drugs plays a vital role for the treatment of cancers and other diseases, and, due to their tunable and inherent properties, PEMCs have shown to be good candidates for smart drug delivery. Herein, we summarize recent progress on the encapsulation of LMW drugs into PEMCs templated onto vaterite CaCO3 crystals. The drug loading and release mechanisms, advantages and limitations of the PEMCs as LMW drug carriers, as well as bio-applications of drug-laden capsules are discussed based upon the recent literature findings.

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Section: The Development Of Polyelectrolyte Multilayer Capsules (Pmentioning

confidence: 99%

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

2020

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“…According to Skirtach et al, polyelectrolyte films showed the capacity of incorporation of nanocarriers and microcarriers, such as liposomes or polymeric capsules. Volodkin et al proposed biocoatings for implant materials consisting in liposomes incorporated in polyelectrolyte coatings assembled using the layer‐by‐layer (LbL) technique, first proposed by Decher in 1991 …”

Section: Introductionmentioning

confidence: 99%

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

Paradiso

Colaço

Mata

et al. 2016

J. Biomed. Mater. Res.

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In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DMPC + cholesterol (DMPC + CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1799-1807, 2017.

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Remote and Self‐Induced Release from Polyelectrolyte Multilayer Capsules and Films

Cited by 2 publications

References 190 publications

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

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