Remodelling of the human vitreous and vitreoretinal interface – A dynamic process

Ponsioen, Theodorus L.; Hooymans, Johanna M. M.; Los, Leonoor I.

doi:10.1016/j.preteyeres.2010.07.001

Cited by 77 publications

(49 citation statements)

References 153 publications

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“…To test this hypothesis, we measured the dynamic material properties on premature (128-136 days gestation), infant ( $150 days gestation) and adult ovine vitreous. There are no official studies comparing the development of the sheep eye at birth to those of a newborn, however, sheep vitreous in general has the same macromolecular organization compared to human vitreous (Noulas et al, 2004;Ponsioen et al, 2010). Additionally, qualitative assessments of the age-dependent collagen distributions in the sheep vitreous currently being collected in our lab are similar to those reported in humans.…”

Section: Introductionmentioning

confidence: 65%

Age-related changes in dynamic moduli of ovine vitreous

Colter

Williams

Moran

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Introductionmentioning

confidence: 65%

Age-related changes in dynamic moduli of ovine vitreous

Colter

Williams

Moran

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…5,19 The general function of the non-collagen elements appears to lie in spacing, binding and linking other ECM components. 20 Glucosaminoglycans (GAGs) can fill space, bind and organize water and interfere with negatively charge molecules. Versican, a proteoglycan with chondroitin sulfate modifications, may contribute to these functions, especially through GAGs, which are attached in the domains encoded by exons 7 and 8 ( Figure 2b).…”

Section: Discussionmentioning

confidence: 99%

Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome

et al. 2012

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Wagner syndrome (WS) is an autosomal dominant vitreoretinopathy affecting various ocular features and is caused by mutations in the canonical splice sites of the VCAN gene, which encodes the large chondroitin sulfate proteoglycan, versican. We report the identification of novel splice acceptor and donor-site mutations (c.4004 À1G4C and c.9265 þ 2T4A) in two large WS families from France and the United Kingdom. To characterize their pathogenic mechanisms we performed qRT-PCR experiments on RNA from patient-derived tissues (venous blood and skin fibroblasts). We also analyzed RNA from the original Swiss family reported by Wagner (who has the previously reported c.9265 þ 1G4A mutation). All three mutations resulted in a quantitative increase of transcript variants lacking exons 7 and/or 8. However, the magnitude of the increase varied between tissues and mutations. We discuss altered balance of VCAN splice variants in combination with reduction in glycosaminoglycan protein modifications as possible pathogenic mechanisms.

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“…Activated and hypertrophic Müller cells (e.g. after partial detachment of the vitreous from the retina) have a major role in epiretinal membrane formation together with vitreous fibers adhering to Müller cells at sites of vitreoretinal attachment [15]. In this way, Müller cells contribute to the formation of gliotic scars and also to increased vascular leakage by releasing growth factors.…”

Section: Pathophysiology Of Metamorphopsiamentioning

confidence: 99%

Metamorphopsia: An Overlooked Visual Symptom

2015

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Metamorphopsia is a common symptom in different macular disorders. Micropsia and macropsia are special types of metamorphopsia. Recent theories suggest that both retinal and cortical mechanisms are involved in the development and changes of metamorphopsia. Different functional tests have been proposed for the evaluation of metamorphopsia: from the Amsler grid to the hand-held mobile devices for home monitoring. This review addresses some new insights into the pathophysiology of metamorphopsia and different available tests for the evaluation of this symptom in most common macular disorders. The importance of quantification of metamorphopsia in macular diseases is confirmed by the most recent therapeutic approaches.

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Remodelling of the human vitreous and vitreoretinal interface – A dynamic process

Cited by 77 publications

References 153 publications

Age-related changes in dynamic moduli of ovine vitreous

Age-related changes in dynamic moduli of ovine vitreous

Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome

Metamorphopsia: An Overlooked Visual Symptom

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