Remodelling of bone around hydroxyapatite and titanium in experimental osteoporosis

Hayashi, Kazuo; Uenoyama, Kazuhide; Mashima, Tatsuoki; Sugioka, Yôichi

doi:10.1016/0142-9612(94)90189-9

Cited by 64 publications

(34 citation statements)

References 22 publications

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“…The histological findings presented a poor interaction between the inserted material and bone tissue, and a low amount of newly formed bone, and were attributed to the osteoporosis-like conditions as a result of gonadal deficiency induced by ovariectomization procedure (Li et al, 2004;Lugero et al, 2000;Pan et al, 2000;Wang et al, 2005). Similar findings have also been reported by De Benedittis et al (1999), Fini et al (1997), Hayashi et al (1994);Jung et al (2001), who, however, used hydroxyapatite as implant material. Statistical analysis did not revealed statistical difference between the BOHR and NO, but these two groups were different in relation to the BOWHR group.…”

Section: Discussionsupporting

confidence: 78%

“…The authors noted poor interaction between the material implanted and bone tissue, as well as a low amount of newly formed bone, and attributed the findings to the osteoporosis-like conditions as a result of gonadal deficiency induced by ovariectomy (Hayashi et al, 1994;Lugero et al, 2000). Similar results have been reported by De Benedittis et al, (1999);Fini et al, (1997); Hayashi et al, (1994);Jung et al, (2001);and Pan et al, (2000), who used hydroxyapatite as implant material. Cunha et al, (2008) confirmed the effects of estrogen deficiency on the delay of bone regeneration in defects created experimentally in the femur of ovariectomized rats and filled with collagen membranes.…”

Section: Discussionsupporting

confidence: 76%

“…However, some discrepancies are reported in the literature regarding the interaction between bone and implants of biomaterials such as titanium and ceramics. Some studies have shown significant bone loss around these biomaterials, whereas others reported no difference in bone growth in the recipient areas of ovariectomized animals (Fini et al, 1997;Hayashi et al, 1994;Pan et al, 2000). This divergence might be due to the difficulty in standardizing methods for the correct quantification of bone tissue formed on the implant (Ozawa et al, 2002).…”

Section: Discussionmentioning

confidence: 90%

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Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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2012Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats MICROSCOPY RESEARCH AND TECHNIQUE, MALDEN, v. 75, n. 2, pp. 133-137, FEB, 2012 http://www.producao.usp.br/handle/BDPI/42523 ABSTRACT Osteoporosis is a global public health that affects postmenopausal women due to the deficiency of estrogen, a hormone that plays an important role in the microarchitecture of bone tissue. Osteoporosis predisposes to pathological bone fracture that can be repaired by conventional methods. However, depending on the severity and quantity of bone loss, the use of autogenous grafts or biomaterials such as hydroxyapatite might be necessary. The latter has received increasing attention in the medical field because of its good biological properties such as osteoconductivity and biocompatibility with bone tissue. The objective of this study was to evaluate using histologic and radiographic analyses, the osteogenic capacity of hydroxyapatite implanted into the femur of rats with ovariectomy-induced osteoporosis. Eighteen rats were divided into three groups with six animals in each: group nonovariectomized, bilaterally ovariectomized not receiving estrogen replacement therapy, and bilaterally ovariectomized submitted to estrogen replacement therapy. Defects were created experimentally in the distal epiphysis of the femur with a surgical drill and filled with porous hydroxyapatite granules. The animals were sacrificed 8 weeks after surgery. The volume of newly formed bone in the implant area was quantified by morphometrical methods. The results were analyzed by ANOVA followed by the Tukey test (P < 0.05). The hydroxyapatite granules showed good radiopacity. Histological analysis revealed less quantity of newly formed bone in the ovariectomized group not submitted to hormone replacement therapy. In conclusion, bone neoformation can be expected even in bones compromised by estrogen deficiency, but the quantity and velocity of bone formation are lower. Microsc. Res. Tech. 75:133-137, 2012. V

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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“…[27][28][29] Søballe et al 30 studied the ingrowth of osteopenic bone into titanium-alloy porous-coated implants with and without HA coating in dogs and concluded that HA-coated implants were not affected by the osteopenic condition. This is the only report in which the integrity between an HA-coated implant and osteoporotic bone has been evaluated mechanically.…”

Section: Discussionmentioning

confidence: 99%

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

Hara¹,

Hayashi

Nakashima³

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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We have studied the effect of hydroxyapatite (HA) coating in 15 ovariectomised and 15 normal rats which had had a sham procedure. Twenty-four weeks after operation, HA-coated implants were inserted into the intramedullary canal of the right femur and uncoated implants into the left femur. The prostheses were removed four weeks after implantation. Twelve specimens in each group had mechanical push-out tests. Sagittal sections of the other three were evaluated by SEM.The bone mineral density (BMD) of the dissected left tibia was measured by dual-energy x-ray absorptiometry. The difference in BMD between the control and ovariectomised tibiae was 35.01 mg/cm 2 (95% CI, 26.60 to 43.42). The push-out strength of the HA-coated implants was higher than that of the uncoated implants in both groups (p < 0.0001), but the HA-coated implants of the ovariectomised group had a reduction in push-out strength of 40.3% compared with the control group (p < 0.0001).Our findings suggest that HA-coated implants may improve the fixation of a cementless total hip prosthesis but that the presence of osteoporosis may limit the magnitude of this benefit. [Br] 1999;81-B:705-9. J Bone Joint Surg Received 26 May 1998; Accepted after revision 4 November 1998Many studies have used animal models to demonstrate the osteoconductive properties of bioactive ceramics, especially hydroxyapatite (HA). Recently, HA-coated implants have been used in total hip replacement (THR), and early clinical results suggest that HA-coated prostheses are an attractive alternative to standard methods of cementless arthroplasty.1-6 The animals used in basic studies on the properties of HA coating had a normal bone metabolism and bone mass. 4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In such animals, the formation and resorption phases of bone are tightly coupled, and bone mass is maintained. We believe, however, that many patients, especially women, who undergo THR, have uncoupling of the phases of bone remodelling and decreased bone mass. 22 Our aim was to confirm the efficiency of HA in osteoporotic conditions and we have studied the bone-implant attachment strength of HA-coated titanium implants in ovariectomised and normal rats. Materials and MethodsExperimental design and operative procedure. We used thirty 12-week-old female Wistar King rats weighing between 243 and 282 g. They were housed and tested at the Institute of Laboratory Animals, Faculty of Medicine, Kyushu University. All the rats were sedated with ether and anaesthetised by peritoneal administration of pentobarbital (40 mg/kg body-weight). They were then divided into two groups. One had bilateral ovariectomy using standard veterinary procedures and the other a sham operation which consisted of exposure and palpation of the ovaries without removal. At 24 weeks after this operation HA-coated and uncoated implants were inserted into the medullary canal of the right and left femora, respectively, in both groups, after reaming the intercondylar notch of each distal femur with a 1.5 mm dri...

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“…Consequently, many preclinical in vivo studies on biomaterials for orthopedic and dental surgery have been conducted using osteopenic animal models. 21,24 -36 The majority of these investigations have been performed in the ovariectomized rat model, 21,24,25,28,[31][32][33][34]36 even if large-size osteopenic animals have been claimed to be more suitable for osteointegration studies on account of their size, which allows the implantation of surgical devices having the same size of those clinically used. In addition, the bone formation rate of large-size animals is more similar to that of humans than that of small-size animals.…”

Section: Discussionmentioning

confidence: 99%

Osteointegration of bioactive glass‐coated and uncoated zirconia in osteopenic bone: An in vivo experimental study

Aldini

Fini

Giavaresi

et al. 2003

J Biomedical Materials Res

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In elderly and osteoporotic patients an age-related loss of osteoinductivity could be the biological cause of implant failure regardless of the high quality of the implanted device. yttria stabilized tetragonal zirconia (YSTZ), either coated with the bioactive glass named RKKP bioglaze (RKKP) or uncoated, was implanted in the distal femurs of sham-operated and ovariectomized female rats. Animals were sacrificed at 30 and 60 days. Histomorphometry and microhardness tests were performed to assess osteointegration rate as well as bone quality around the implants. Significant decreases (p < 0.0005) in trabecular bone volume, BV/TV (41%), trabecular bone surface BS/TV (33%), trabecular thickness Tb.Th (20%), and trabecular number Tb.N (32%), together with a significant increase in trabecular separation Tb.Sp (184%), were found for the osteopenic rats compared with the sham-operated rats. At both experimental times the RKKP coating ensured a better osteointegration rate with higher AI values than the uncoated YSTZ, even when osteopenic rats were used (48% at 30 days and 12% at 60 days). No differences were observed at the bone-biomaterial interfaces for either material when comparing sham-operated with osteopenic rats. The present results demonstrate that the RKKP bioactive glass used as a coating ensures a high osteointegration rate even in osteoporotic bone, which is already visible from postoperative day 30 and is still apparent on day 60.

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Remodelling of bone around hydroxyapatite and titanium in experimental osteoporosis

Cited by 64 publications

References 22 publications

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

The effect of hydroxyapatite coating on the bonding of bone to titanium implants in the femora of ovariectomised rats

Osteointegration of bioactive glass‐coated and uncoated zirconia in osteopenic bone: An in vivo experimental study

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