Remodeling of the Extracellular Matrix in the Aging Lung

Roman, Jesse

doi:10.1002/9781118396292.ch11

Cited by 3 publications

(3 citation statements)

References 88 publications

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“…However, tissue remodeling can occur without overt changes in the tissue architecture. This process has been termed transitional remodeling and is characterized by subtle alterations in the relative composition of the ECM without resulting in microscopic or macroscopic changes in the tissue architecture [ 86 ]; in fact, this tissue remodeling can only be detected via biochemical studies, an evaluation of the mRNA expression, or immunohistochemistry. The exact impact of transitional remodeling on organ function is unknown, but it is not hard to imagine that such changes affect cellular adhesion, migration, and differentiation, among other processes, considering that cells have the capability of recognizing distinct ECM components via integrin receptors.…”

Section: Fibroblast-derived Ecms In Health and Diseasementioning

confidence: 99%

Fibroblasts—Warriors at the Intersection of Wound Healing and Disrepair

Roman

2023

Biomolecules

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Wound healing is triggered by inflammation elicited after tissue injury. Mesenchymal cells, specifically fibroblasts, accumulate in the injured tissues, where they engage in tissue repair through the expression and assembly of extracellular matrices that provide a scaffold for cell adhesion, the re-epithelialization of tissues, the production of soluble bioactive mediators that promote cellular recruitment and differentiation, and the regulation of immune responses. If appropriately deployed, these processes promote adaptive repair, resulting in the preservation of the tissue structure and function. Conversely, the dysregulation of these processes leads to maladaptive repair or disrepair, which causes tissue destruction and a loss of organ function. Thus, fibroblasts not only serve as structural cells that maintain tissue integrity, but are key effector cells in the process of wound healing. The review will discuss the general concepts about the origins and heterogeneity of this cell population and highlight the specific fibroblast functions disrupted in human disease. Finally, the review will explore the role of fibroblasts in tissue disrepair, with special attention to the lung, the role of aging, and how alterations in the fibroblast phenotype underpin disorders characterized by pulmonary fibrosis.

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Section: Fibroblast-derived Ecms In Health and Diseasementioning

confidence: 99%

Fibroblasts—Warriors at the Intersection of Wound Healing and Disrepair

Roman

2023

Biomolecules

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“…It has been proposed that the aged lung is characterized by subtle changes in the ECM and lung architecture, which does not directly cause disease or changes in lung function, so-called transitional remodeling [68]. When the lung is then exposed to an additional insult, like in COPD, these alterations may trigger an aberrant repair response and cause permanent tissue damage.…”

Section: Aging and Lung Ecm Changes In Copdmentioning

confidence: 99%

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

Brandsma

Berge

Hackett

et al. 2019

The Journal of Pathology

144

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Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease-modifying treatment. The biggest drawback of today's COPD treatment regimen is the 'one size fits all' pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age-related changes, structural changes in the small airways and the role of sex-related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD.

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“…Furthermore, there is now increasing recognition that proximal airway diseases such as asthma in the elderly are a distinct entity representing an increasing healthcare burden (5). In these diseases, beyond functional effects such as airway hyperreactivity, remodeling of the airways and parenchyma resulting from altered cell proliferation and extracellular matrix (ECM) formation is one of the key features that is also observed in normal aging lung (6)(7)(8)(9) and contributes to impairment of gas exchange and overall lung function decline (10)(11)(12). Thus it becomes important to understand common mechanisms in the lung that contribute to normal aging versus aging-associated diseases, toward development of novel biomarkers and therapeutics in a vulnerable population.…”

Section: Introductionmentioning

confidence: 99%

The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête

et al. 2021

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Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.

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Remodeling of the Extracellular Matrix in the Aging Lung

Cited by 3 publications

References 88 publications

Fibroblasts—Warriors at the Intersection of Wound Healing and Disrepair

Fibroblasts—Warriors at the Intersection of Wound Healing and Disrepair

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête

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