Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration
Maj Schneider Thomsen,
Serhii Kostrikov,
Lisa Juul Routhe
et al.
Abstract:Background: Chronic neurodegenerative diseases are characterized by substantial neuroinflammation with accumulation of macrophages, reactive microglia, and reactive astrocytes. Impairment of the brain vasculature is also commonly seen in chronic neurodegeneration with causal links warranting further investigation. Methods: To address the effects of chronic neurodegeneration on regional vasculature, we performed a unilateral injection of a glutamate receptor agonist ibotenic acid into striatum of adult rats, wh… Show more
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