Remodeling of Myocardium in Rat with Chronic Dyslipidemia and under Conditions of Verapamil Treatment

Клинникова, М. Г.; Yuzhik, E. I.; Pichigin, V. I.; Лушникова, Е. Л.

doi:10.1007/s10517-014-2701-z

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…We showed previously that the cytopathic effect of dyslipemia manifested by more intense lythic lesions of cardiomyocytes, development of diffuse and small focal cardiosclerosis in the presence of pronounced circulatory disorders [1]. The volumic connective tissue/cardiomyocyte proportion increased throughout the experiment: by 74% after 30 days and by 58-62% after 64 days of the experiment.…”

Section: Resultsmentioning

confidence: 72%

Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia

et al. 2015

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The regeneratory reactions of cardiomyocytes in the heart under conditions of cytopathic exposure to hypercholesterolemia and during verapamil treatment were studied by immunohistochemical detection of proliferation marker Ki-67 and evaluation of cardiomyocyte count. A 30-day exposure of rats to atherogenic diet led to an increase of Ki-67+ cardiomyocytes by 14.5-16.7 times (p<0.05). The Ki-67 label index in cardiomyocytes remained higher than normally (8-9-fold; p<0.05) after 64 days. It remained elevated (8-11-fold; p<0.05) after verapamil treatment. Evaluation of cardiomyocyte count and of their nuclear status detected various regeneratory strategies: increase of the total cardiomyocyte count, with increase of the percentage of mononuclear cardiomyocytes (particularly in response to verapamil in group 1 rats); decrease of total cardiomyocyte count with increase of the percentage of multinuclear cardiomyocytes (particularly in group 2 rats in response to verapamil).

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Section: Resultsmentioning

confidence: 72%

Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia

et al. 2015

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Immunohistochemical Analysis of MMP-2 Expression in the Myocardium During the Postinfarction Period

et al. 2015

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Immunohistochemical analysis revealed 2.5-fold increased of expression MMP-2 in myocardium samples during the early period (up to 3 days) of postinfarction reparative regeneration. During this period, MMP-2 was detected mainly in monocytes/macrophages circulating in the blood and migrating to the necrotic zone, while expression in the intermuscular and perivascular connective tissue was lower. At later terms, with development of large focal and diffuse cardiosclerosis, MMP-2 expression significantly decreased (to the initial level) and was detected mainly in the foci of intermuscular and perivascular fibrosis, its area in the sections increased by 1.8 times. Evaluation of MMP-2 expression in the blood vessels showed that the immunohistochemical reaction was the most pronounced in the walls of new sinusoidal vessels and the minimum in the intramural arteries of medium diameter. These results attest to an important role of MMP in connective tissue remodeling (proteolytic degradation) during the early period of postinfarction reparative regeneration. The decrease in MMP-2 expression observed at later terms correlated with myocardial fibrosis progression.

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Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide

et al. 2016

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Changes in the blood lipid spectrum and structural reorganization of the rat myocardium in response to injection of a single sublethal dose of doxorubicin (7 mg/kg) alone and in combination with course administration of betulonic acid amide (100 mg/kg/day for 14 days) were studied. Betulinic acid amide in the specified dose exhibited less pronounced cardiotoxic (necrobiotic impairment of cardiomyocytes) and dyslipidemic (increase of cholesterol and triglyceride levels) effects in comparison with doxorubicin. Combined treatment with betulinic acid amide and doxorubicin led to more pronounced remodeling of the myocardium, which was shown by a significant increase of the connective tissue/cardiomyocyte volume ratio detected by day 14 of the experiment.

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Remodeling of Myocardium in Rat with Chronic Dyslipidemia and under Conditions of Verapamil Treatment

Cited by 4 publications

References 14 publications

Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia

Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia

Immunohistochemical Analysis of MMP-2 Expression in the Myocardium During the Postinfarction Period

Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide

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