“…Nevertheless, it has been shown that curvature selectivity by aSyn cannot be comprehensively characterized through measurements of affinity alone (54), and further studies will be required to evaluate more directly the curvature selectivity of Ac-aSyn. In addition, it is now generally accepted that aSyn can influence membrane properties, specifically curvature, in addition to sensing them (57,58,60,62,63,66,75,83), and the influence of N-terminal acetylation on this activity of the protein remains to be explored.…”