1997
DOI: 10.1161/01.cir.96.2.475
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Remodeling of Human Coronary Arteries Undergoing Coronary Angioplasty or Atherectomy

Abstract: To understand remodeling of human coronary arteries undergoing coronary angioplasty or atherectomy, serial intravascular ultrasonographic examinations were performed at preintervention and postintervention examinations and at 24 hours, 1 month, and 6 months. Complete serial data were obtained in 61 lesions (balloon angioplasty, 35 lesions; directional atherectomy, 26 lesions). Lumen area improved from 6.81+/-2.24 mm2 after intervention to 8.22+/-2.79 mm2 at 1 month (P=.0001) and decreased to 4.88+/-2.86 mm2 at… Show more

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Cited by 207 publications
(107 citation statements)
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“…In a study by Nagai et al [5], the incidence of RAO was found to be 5% by evaluation of the radial artery at 95 ± 29 days following the procedure. This short period of follow up equals with the ongoing process of both remodeling and intimal thickening [11,12]. Likewise, chronic phase vascular complications such as diffuse stenosis and loss of forward flow may mimic the same physiopathology of restenosis related to angioplasty [13,14].…”
Section: Discussionmentioning
confidence: 99%
“…In a study by Nagai et al [5], the incidence of RAO was found to be 5% by evaluation of the radial artery at 95 ± 29 days following the procedure. This short period of follow up equals with the ongoing process of both remodeling and intimal thickening [11,12]. Likewise, chronic phase vascular complications such as diffuse stenosis and loss of forward flow may mimic the same physiopathology of restenosis related to angioplasty [13,14].…”
Section: Discussionmentioning
confidence: 99%
“…The mean luminal loss observed after DCA by the core laboratory was 0.81 mm, 14,16 which is Ͼ2 times the average after balloon angioplasty. 2,3,14,16 Before intravascular ultrasound (IVUS) studies, which changed our perception of restenosis, [21][22][23] we assumed this renarrowing was due to neointimal hyperplasia. 24 For this reason, the investigation of an agent with antioxidant, antichemotactic, and direct antiproliferative effects seemed ideally suited to an atherectomytreated patient population.…”
Section: Appropriateness Of Dca-treated Patients For This Trialmentioning
confidence: 99%
“…24 For this reason, the investigation of an agent with antioxidant, antichemotactic, and direct antiproliferative effects seemed ideally suited to an atherectomytreated patient population. IVUS studies have since demonstrated that vessel remodelling may account for Ͼ50% of the luminal renarrowing response after DCA, 21,22 which reduces the target for antiproliferative drugs. However, if the report by Côté et al 6 on probucol is correct, the antioxidant effects of carvedilol should have the potential to inhibit vascular remodelling as well as inflammation such that a general reduction of the response to injury could have been reasonably expected.…”
Section: Appropriateness Of Dca-treated Patients For This Trialmentioning
confidence: 99%
“…It has been well established that formation of neointima in vascular diseases is associated with impaired assembly of tropoelastin into insoluble elastin (1)(2)(3)(4)(5)(6) and with extensive degradation of the elastin-rich extracellular matrix by numerous proteinases leaking from the serum and secreted from the infiltrating platelets, leukocytes, and activated vascular cells (7)(8)(9)(10). It has also been suggested that local accumulation of non-assembled tropoelastin and small elastin-derived peptides may constitute an important factor in the activation of the normally quiescent medial SMC 1 into the proliferative and migratory phenotype, which participates in the formation of the occlusive neointima in vascular diseases (2,3,(11)(12)(13)(14)(15).…”
mentioning
confidence: 99%