Remodeling of brain morphology in temporal lobe epilepsy

Roggenhofer, Elisabeth; Muller, Sandrine; Santarnecchi, Emiliano; Melie‐García, Lester; Wiest, Roland; Kherif, Ferath; Draganski, Bogdan

doi:10.1002/brb3.1825

Cited by 2 publications

(1 citation statement)

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“…Similar findings were reported in previous study of FLE (Woodward et al, 2014). Connections between temporal lobe and sensorimotor cortex have been repeatedly reported in previous neuroimaging studies of MRI-negative TLE patients, especially for right MTS to influence ipislateral thalamus and temporal pole (Coan et al, 2014;Roggenhofer et al, 2020). In addition to TLE, temporal pole and precentral gyrus involvement is also reported for patients with GTCS (Liu et al, 2017;Li et al, 2020).…”

Section: Discussionsupporting

confidence: 86%

Topological abnormality of structural covariance network in MRI-negative frontal lobe epilepsy

Liu

et al. 2023

Front. Neurosci.

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BackgroundFrontal lobe epilepsy (FLE) is the second most common type of focal epilepsy, however, imaging studies of FLE have been far less than Temporal lobe epilepsy (TLE) and the structural findings were not consistent in previous literature.ObjectInvestigate the changes in cortical thickness in patients with FLE and the alteration of the structural covariance networks (SCNs) of cortical thickness with graph-theory.MethodThirty patients with FLE (18 males/12 females; 28.33 ± 11.81 years) and 27 demographically matched controls (15 males/12 females; 29.22 ± 9.73 years) were included in this study with high-resolution structural brain MRI scans. The cortical thickness was calculated, and structural covariance network (SCN) of cortical thickness were reconstructed using 68 × 68 matrix and analyzed with graph-theory approach.ResultCortical thickness was not significantly different between two groups, but path length and node betweenness were significantly increased in patients with FLE, and the regional network alterations were significantly changed in right precentral gyrus and right temporal pole (FDR corrected, p < 0.05). Comparing to HC group, network hubs were decreased and shifted away from frontal lobe.ConclusionThe topological properties of cortical thickness covariance network were significantly altered in patients with FLE, even without obvious surface-based morphological damage. Graph-theory based SCN analysis may provide sensitive neuroanatomical biomarkers for FLE.

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Section: Discussionsupporting

confidence: 86%