Remnant cholesterol and atherosclerotic disease in high cardiovascular risk patients. Beyond LDL cholesterol and hypolipidemic treatment

Delialis, Dimitrios; Georgiopoulos, Georgios; Aivalioti, Evmorfia; Mavraganis, Georgios; Dimopoulou, Angeliki-Maria; Sianis, Alexandros; Aggelidakis, Lasthenis; Patras, Raphael; Petropoulos, Ioannis N.; Ioannou, Sofia; Syrigou, Rodanthi; Chatzidou, Sofia; Kanakakis, John; Stellos, Konstantinos; Stamatelopoulos, Kimon

doi:10.1016/j.hjc.2022.05.011

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…23 Consistent with our results, in the previous studies, RC had an association with the incidence of ASCVD but not LDL-C, even if the population received statin therapy and had lower LDL-C concentrations. [24][25][26][27] Castañer and colleagues analysed the data from the PREDIMED trial, and their results demonstrated that the concentrations of RC and TG were related to cardiovascular outcomes, not LDL-C, in a group of Mediterranean participants who had high cardiovascular risks. 28 Furthermore, one of the recent prospective studies suggested that in individuals without known ASCVD, elevated RC concentrations had an association with ASCVD but not non-HDL-C, ApoB or LDL-C.…”

Section: Discussionmentioning

confidence: 99%

Remnant cholesterol is associated with unstable carotid plaque in a neurologically healthy population

Li,

Liu,

Liu

et al. 2024

Stroke Vasc Neurol

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BackgroundRemnant cholesterol (RC) is considered to be one of the most significant and important risk factors for atherosclerotic cardiovascular disease (ASCVD). Nonetheless, the association between RC and unstable carotid plaque remains unclear. Our primary objective is to ascertain whether RC exhibits an independent and significant association with unstable carotid plaque in a neurologically healthy population.MethodsIn the cross-sectional study, we enrolled neurologically healthy participants who visited our centre for health checkups between 2021 and 2022. All eligible participants underwent a standardised questionnaire, physical examinations and laboratory testing. The carotid plaque was evaluated with a standard carotid ultrasound and an advanced ultrasound imaging technique called superb microvascular imaging. The correlation between lipids and unstable carotid plaque was primarily assessed utilising univariate and multivariate logistic regression.ResultsThe study totally enrolled 1100 participants who had an average age of 57.00 years (IQR: 49.00–63.00), with 67.55% being men. Among the participants, 321 (29.18%) had unstable carotid plaque. In the multivariate logistic regression analysis, higher RC had an independent association with an elevated incidence of unstable carotid plaque compared with the lowest concentrations of RC (OR=1.673, 95% CI 1.113 to 2.515, p=0.0134), but not other lipids. In addition, apolipoprotein A1 was negatively related to unstable carotid plaque (OR=0.549, 95% CI 0.364 to 0.830, p=0.0045).ConclusionsElevated concentrations of RC are independently and excellently correlated with unstable carotid plaque within a neurologically healthy population.

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Section: Discussionmentioning

confidence: 99%

Remnant cholesterol is associated with unstable carotid plaque in a neurologically healthy population

Li,

Liu,

Liu

et al. 2024

Stroke Vasc Neurol

View full text Add to dashboard Cite

show abstract

“…The mechanism underlying this relationship is not fully understood. It may be that elevated RC concentrations not only contribute to atherosclerosis similar to LDL-C ( 28 , 29 ), but also promote systemic low-grade inflammation ( 30 ). Furthermore, studies have shown that RC can enhance the expression of adhesion molecules, coagulation factors, and inflammatory proteins in endothelial cells, leading to monocyte recruitment and attachment, and promote foam cell formation ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Association of remnant cholesterol with renal function and its progression in patients with type 2 diabetes related chronic kidney disease

Li,

Wang,

Shao

et al. 2024

Front. Endocrinol.

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BackgroundThe association of Remnant cholesterol (RC) with renal function and its progression in patients with Type 2 diabetes (T2DM) related chronic kidney disease (CKD) remains unclear.Methods8,678 patients with T2DM-related CKD were included in cross-sectional analysis, and 6,165 patients were enrolled in longitudinal analysis and followed up for a median of 36.0 months. The outcomes were renal composite endpoint event and rapid progression of renal function.Results24.54% developed a renal composite endpoint event, and 27.64% rapid progression of renal function. RC levels above 0.56 mmol/L independently increased the risk of both renal composite endpoint (HR, 1.17; 95% CIs, 1.03-1.33) and rapid progression of renal function (OR, 1.17; 95% CIs, 1.01- 1.37). TG levels above 1.65 mmol/L only increased the risk of renal composite endpoint (HR, 1.16; 95% CIs, 1.02 -1.32). TC levels above 5.21 mmol/L increased the risk of renal composite endpoint (HR, 1.14; 95% CIs, 1.01-1.29) only in patients with proteinuria≥0.5g/d. Conversely, HDL-C levels below 1.20 mmol/L or above 1.84 mmol/L increased the risk of rapid progression of renal function (OR, 0.88; 95% CIs, 0.70 -0.99) in patients with proteinuria<0.5g/d (all P<0.05).ConclusionIn patients with T2DM-related CKD, RC was an independent risk factor for progression of renal function, and maintaining it below 0.56 mmol/L could reduce the risk of renal function progression.

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Remnant cholesterol in atherosclerotic cardiovascular disease: A systematic review and meta-analysis

Delialis

Georgiopoulos

Aivalioti

et al. 2023

Hellenic Journal of Cardiology

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Remnant cholesterol and atherosclerotic disease in high cardiovascular risk patients. Beyond LDL cholesterol and hypolipidemic treatment

Cited by 7 publications

References 29 publications

Remnant cholesterol is associated with unstable carotid plaque in a neurologically healthy population

Remnant cholesterol is associated with unstable carotid plaque in a neurologically healthy population

Association of remnant cholesterol with renal function and its progression in patients with type 2 diabetes related chronic kidney disease

Remnant cholesterol in atherosclerotic cardiovascular disease: A systematic review and meta-analysis

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