Remitting seronegative symmetrical synovitis with pitting edema associated with parvovirus B19 infection: two new cases and review of the comorbidities

Drago, Francesco; Ciccarese, Giulia; Agnoletti, Arianna Fay; Cogorno, Ludovica; Muda, Alessandro; Cozzani, Emanuele; Parodi, Aurora

doi:10.1111/ijd.12854

Cited by 22 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The hypothesis has long been considered that in a genetically predisposed patient, an environmental factor, possibly a virus, may induce monocyte and dendritic cell activation and the production of pro-inflammatory cytokines that induce manifestations characteristic of PMR (21,22). However, although several infectious agents have been investigated as possible triggers, the results are inconclusive.…”

Section: N Infectious Agentsmentioning

confidence: 99%

“…Cimmino et al demonstrated that antibodies to adenovirus (ADV) and respiratory syncytial virus (RSV) were significantly more prevalent in PMR patients, suggesting that ADV and RSV might be the possible microorganisms responsible for triggering PMR in elderly people (24). Although a few studies reported the presence of an association between parvovirus B19 and PMR, the results have been not replicated in larger studies (21,25). Finally, no role of current or previous hepatitis B virus infection has been demonstrated in the pathogenesis of the majority of cases of polymyalgia rheumatic (26).…”

Section: N Infectious Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis of polymyalgia rheumatica

Guggino¹,

Ferrante²,

Macaluso³

et al. 2018

Reumatismo

View full text Add to dashboard Cite

REVIEW SUMMARYPolymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells. Disturbed B cell distribution and function have been also demonstrated in PMR patients suggesting a pathogenesis more complex than previously imagined. In this review we will discuss the recent findings regarding the pathogenesis of PMR.

show abstract

Section: N Infectious Agentsmentioning

confidence: 99%

Section: N Infectious Agentsmentioning

confidence: 99%

Pathogenesis of polymyalgia rheumatica

Guggino¹,

Ferrante²,

Macaluso³

et al. 2018

Reumatismo

View full text Add to dashboard Cite

show abstract

“…The most typical is the papular purpuric 'gloves and socks' syndrome , but atypical exanthems, have been reported and may pose a diagnostic challenge. So far, systemic contributes dealing with atypical exanthems in the course of B19V infection are very limited whereas single case reports have been more frequently described . In our series of 390 consecutive patients with atypical exanthems, including 120 children and 270 adults, B19 V infection was found in approximately 5% of cases, both in children and adults.…”

Section: Discussionmentioning

confidence: 70%

Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults

Drago

Ciccarese

Broccolo

et al. 2015

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

Parvovirus B19 (B19V) infection may differently manifest in various age groups. Erythema infectiosum ('fifth disease') is the most common B19V manifestations in children. Arthralgias and arthritis, with or without rash, are common manifestations of B19V infection in adults. Pruritus is usually present in adults and children. However, other cutaneous manifestations and atypical exanthems have been occasionally reported during B19V infection. To investigate the putative role of B19V infection in atypical exanthems, a total of 390 consecutive patients with atypical exanthems were analysed for B19V infection by determining B19V IgG and IgM antibodies titres in acute and convalescent phase as well as B19V DNA detection in serum by polymerase chain reaction (PCR). Atypical exanthems resulted related to B19V infection in 6 of the 120 pediatric (5%) and 14 of the 270 adult patients (5.2%). In conclusion this study reveals that atypical exanthems related to B19V infection are possible both in children and in adults, with a similar prevalence.

show abstract

“…No other cause for RS3PE has been found and the authors suggested an etiological relationship between RS3PE and Parvovirus B19 infection 24 . Similarly, Drago et al described another two cases who had RS3PE syndrome associated with Parvovirus B19 infection 25 . In general no clear association was reported between an infectious agent and RS3PE.…”

Section: Etiopathogenesismentioning

confidence: 86%

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome

Gökçen¹,

Kozanoğlu²

2017

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

View full text Add to dashboard Cite

AbstractÖz Remitting seronegative symmetrical synovitis with pitting edema is a rare rheumatological disorder that presents with symmetrical hand and/or foot edema resembling rheumatoid arthritis. It is generally seen in male patients in older age, but atypical cases in different age groups have been documented. Although no clear mechanism has been described, certain genetic and environmental factors have been suggested for etiopathogenesis. Medical treatment is mainly focused on glucocorticoid therapy. This article aims to discuss the Remitting seronegative symmetrical synovitis with pitting edema syndrome and to review the current literature.Tekrarlayıcı seronegatif pitting ödemli simetrik sinovit sendromu, romatoid artriti andıran simetrik el ve/veya ayak ödemi ile prezente olan nadir görülen bir hastalıktır. Genellikle ileri yaş erkek hastalarda görülür fakat farklı yaş gruplarında görülen atipik vakalar da bulunmaktadır. Net bir mekanizma tanımlanmamış olmasına rağmen, etiyopatogenezde belli genetik ve çevresel faktörler öne sürülmektedir. Tedavi, esasen glukokortikoid tedavisi üzerine odaklanmaktadır. Bu derlemede Tekrarlayıcı seronegatif pitting ödemli simetrik sinovit sendromunun tartışılması ve literatürün gözden geçirilmesi amaçlanmıştır.

show abstract

Remitting seronegative symmetrical synovitis with pitting edema associated with parvovirus B19 infection: two new cases and review of the comorbidities

Abstract: We want to underline the importance for patients with RS3PE to be seen by dermatologists who should become familiar with this syndrome and remark that Parvovirus B19 infection may be a potential cause of RS3PE.

Cited by 22 publications

References 18 publications

Pathogenesis of polymyalgia rheumatica

Pathogenesis of polymyalgia rheumatica

Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome

Contact Info

Product

Resources

About