Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome following spontaneous rupture of a gouty tophus

Sugisaki, Kota; Hirose, Taro

doi:10.1007/s10165-008-0105-5

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…These rheumatic conditions are systemic lupus erythematosus [40], gout [41], Sjogren's syndrome [42], polyarteritis nodosa [43], ankylosing spondylitis [44], sarcoidosis [45], amyloidosis [46], relapsing polychondritis [27], and bronchiolitis obliterans organizing pneumonia [47]. In addition, other medical conditions or drugs associated with RS3PE include diabetes mellitus [48], dipeptidyl peptidase-4 inhibitors [49], rifampin [50], and insulin therapy [51].…”

Section: Rs3pe Is Associated With Diseases and Medications Other Thanmentioning

confidence: 99%

RS3PE: Clinical and Research Development

Altman

Yao

2015

Curr Rheumatol Rep

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Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis.

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Section: Rs3pe Is Associated With Diseases and Medications Other Thanmentioning

confidence: 99%

RS3PE: Clinical and Research Development

Altman

Yao

2015

Curr Rheumatol Rep

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“…[23] Sugisaki and Hirose reported another gout-associated RS3PE syndrome case in which NSAID treatment exerted no therapeutic effect and was finally successfully treated with low-dose oral prednisolone. [24] Recent studies have demonstrated the association of RS3PE with antidiabetic drugs such as insulin and dipeptidyl peptidase-4 (DPP-4) inhibitör Yamauchi et al reported two Japanese cases of RS3PE syndrome, which arose after the onset of DPP4 treatment. [25,26] Yokota and Igaki reported a case of polyarthritis developing after the initiation of sitagliptin, diagnosed with RA, and whose arthritis improved after the withdrawal of sitagliptin.…”

Section: Discussionmentioning

confidence: 99%

Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome: A Single-Center Experience

Tezcan

Gülcemal

Limon

et al. 2021

Journal of Contemporary Medicine

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Objective: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare disorder characterized by pitting edema, the onset of acute polyarthritis, and negative rheumatoid factor. The absence of joint erosion and good long-term response to low-dose steroids are its other characteristics. The present study aimed to evaluate the characteristics and accompanying conditions of RS3PE for contributing to the literature on the issue. Material and method: This is cross-sectional descriptive study was carried out in a rheumatology clinic between January 2019- October 2020. Fifteen patients over 18 diagnosed with RS3PE were included in the study. Results: Of 15 patients diagnosed with RS3PE, seven were female, and eight male. The following comorbid disorders were present: relapsing polychondritis, scleroderma, seropositive rheumatoid arthritis, gout, monoclonal gammopathy of unknown significance, and primary myelofibrosis. Most patients other than the ones who have hematological malignities and those diagnosed with relapsing polychondritis responded rapidly to steroids, and no recurrence occurred. Conclusion: RS3PE may be associated with neoplasia, drugs, and various rheumatismal conditions, suggesting that it may be heterogeneous and considered a paraneoplastic rheumatic disease. The rare occurrence of this syndrome leads clinicians to miss it commonly. It is essential to increase awareness of this entity among clinicians.

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“…Constitutional symptoms including fever, malaise, fatigue and weight loss can be seen. Although the name includes the term synovitis, the most characteristic finding is tenosynovitis of the extensor tendons of the hands, RS3PE has been described in association with other rheumatologic disease including sarcoidosis [3], gout [4], Sjogren syndrome [5] and polymyalgia rheumatica [6,7].…”

Section: Discussionmentioning

confidence: 99%

Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge

Aulická¹,

Horák²,

Mrázová³

et al. 2016

Neuropsychiatry (London)

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Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare form of inflammatory arthritis, most often affecting elderly individuals and characterized by polyarthritis most commonly affecting the hands and feet in a symmetric fashion, associated with pitting edema on the dorsum of the hands (and occasionally the feet). Symptoms often spontaneously remit and are usually very responsive to low dose glucocorticoids. RS3PE has been considered as forme fruste of polymyalgia rheumatica. It can also occur as a paraneoplastic syndrome and can sometimes be a harbinger of malignancy. This article describes a case of RS3PE, followed by a review of literature about this very intriguing rheumatologic disease.

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Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome following spontaneous rupture of a gouty tophus

Cited by 7 publications

References 9 publications

RS3PE: Clinical and Research Development

RS3PE: Clinical and Research Development

Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome: A Single-Center Experience

Malignant catatonia due to anti-NMDA-receptor encephalitis in a 15-year-old girl: case report and summary of current knowledge

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