Remission Rate Of Acute Lymphoblastic Leukemia (all) In Adolescents And Young Adults (aya)

Vallacha, Anita; Haider, Ghulam; Raja, Wiky; Kumar, Dinesh

doi:10.29271/jcpsp.2018.02.118

Cited by 4 publications

(5 citation statements)

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“…Acute lymphoblastic leukemia, although the most common hematologic neoplasm in children, is less common in adolescents and adults and has a survival rate of 20% to 40. [11][12][13] Symptoms of the disease are nonspecific and often include fever, fatigue, bruising and bleeding due to thrombocytopenia and infection due to neutropenia, but other symptoms include hepatomegaly and splenomegaly and joint pain. However, the occurrence of cholestatic jaundice in this disease and as one of the early manifestations is very rare.…”

Section: Discussionmentioning

confidence: 99%

A Rare Acute Lymphoblastic Leukemia in a Patient Infected with Epstein-Barr Virus: A Case Report

Heidary

Moghaddam

Zahedi

et al. 2023

Preprint

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Section: Discussionmentioning

confidence: 99%

A Rare Acute Lymphoblastic Leukemia in a Patient Infected with Epstein-Barr Virus: A Case Report

Heidary

Moghaddam

Zahedi

et al. 2023

Preprint

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“…Using Open-Epi software for sample size calculation, a sample size of 84 was selected to represent the true population based on the anticipated proportion of 70% remission in ALL cases, keeping a 95% confidence level and 6% absolute precision due to feasibility issues. 3 A total of 84 diagnosed patients of Acute lymphoblastic leukemia (ALL) undergoing induction of remission were included. The diagnosis in all these patients was based on cytological including Giemsa stained peripheral blood smear, bone marrow aspirate smears, and trephine biopsy, immune-phenotypic and cytogenetic criteria.…”

Section: Methodsmentioning

confidence: 99%

“…A local study covering Sindh province reported 70% remission in pediatric age. 3 Regarding remission, literature has reported the clinical significance of hematological markers (reticulocyte count, ANC, and platelet) to predict remission in cases of ALL. A regular increase in trends of using these markers has dramatically decreased the frequencies of invasive procedures like bone marrow aspiration and trephine.…”

Section: Introductionmentioning

confidence: 99%

Reticulocyte Count and Platelet Count as Predictors of Morphological Remission/Hemopoitic Recovery in Acute Lymphoblastic Leukemia (ALL) after Induction Chemotherapy

Riaz¹

2022

JRMC

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Objectives: To determine the predictive values of reticulocyte and platelet count for remission in cases of acute lymphoblastic leukemia after induction therapy. Materials and Methods:This cross-sectional observational study was conducted in the department of hematology, MTI Hayatabad Medical Complex, Peshawar. All cases of ALL referred to the department for remission after taking induction therapy, irrespective of age and gender were included. Relevant information wascollected on a predesigned proforma prepared in accordance with the objectives of the study. Results: A total of 84 cases referred for remission were included, 56(66.7%) were males and 28 (33.3%) were females. 50(59.5%) cases were in the age range of 5-18 years. The mean with a standard deviation of the age of patients was 15+ 4 years. 75(89.3%) of the cases were classified into ALL-1) by FAB classification. 50(59.5%) of the referred cases had achieved morphological remission by bone marrow aspiration. There was a statistically significant rise in Platelet count of the remission vs non-remission cases (p-0.001). Again there was a statistically significant difference in the retic count of the cases with remission (p-0.05). We observed a statically significant downhill moderate correlation ofretic count with remission (in termsof blast count of BM aspiration) (p-0.04, r:-0.32). Platelet count also had an inverse significant correlation with remission ( p-0.01, r:-0.37). The diagnostic roles of the peripheral platelet count and retic yielded an area under curves of (0.768 and 0.648 respectively) to predict remission.We observed that the retic count and platelet count havebeen shown to have strong predictive valuesfor remission in ALL with interaction values of (R= 0.28**, ΔR²=0.02, p=0.08). Similarly, an increase in platelet also has a strong predictive value for remission in ALL cases with interaction values of (R= 0.41**, ΔR²=0.16, p=0.001) Conclusion: In ALL cases of post-induction therapy, The peripheral blood reading for an increase in Retic and platelet count predictsremission with 95% confidence. These values if strictly observed can reduce the frequency of invasive procedures like bone marrow aspiration. Keywords: ALL, Remission, Reticulocyte count, Platelet count.

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“…As a malignant hematological condition, adult B-cell acute lymphoblastic leukemia (B-ALL) is caused by the abnormal proliferation of B-lymphocyte lineage precursor cells in the bone marrow. Studies have shown that complete remission is achievable in most patients with B-ALL after receiving induction chemotherapy [ 1 , 2 ]. However, the recurrence, drug resistance and extramedullary infiltration during treatment remain the chief reasons for the poor efficacy in B-ALL patients, and the long-term efficacy is not optimistic [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6

Pan,

Hu,

Liu

et al. 2023

J Transl Med

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Background The tumor microenvironment (TME) is a supportive environment responsible for promoting the growth and proliferation of tumor cells. Current studies have revealed that the bone marrow mesenchymal stem cells (BM-MSCs), a type of crucial stromal cells in the TME, can promote the malignant progression of tumors. However, in the adult B-cell acute lymphoblastic leukemia (B-ALL) microenvironment, it is still uncertain what changes in BM-MSCs are induced by leukemia cells. Methods In this study, we mimicked the leukemia microenvironment by constructing a BM-MSC–leukemia cell co-culture system. In vitro cell experiments, in vivo mouse model experiments, lentiviral transfection and transcriptome sequencing analysis were used to investigate the possible change of BM-MSCs in the leukemia niche and the potential factors in BM-MSCs that promote the progression of leukemia. Results In the leukemia niche, the leukemia cells reduced the MSCs' capacity to differentiate towards adipogenic and osteogenic subtypes, which also promoted the senescence and cell cycle arrest of the MSCs. Meanwhile, compared to the mono-cultured MSCs, the gene expression profiles of MSCs in the leukemia niche changed significantly. These differential genes were enriched for cell cycle, cell differentiation, DNA replication, as well as some tumor-promoting biofunctions including protein phosphorylation, cell migration and angiogenesis. Further, interferon alpha-inducible protein 6 (IFI6), as a gene activated by interferon, was highly expressed in leukemia niche MSCs. The leukemia cell multiplication was facilitated evidently by IFI6 both in vitro and in vivo. Mechanistically, IFI6 might promote leukemia cell proliferation by stimulating SDF-1/CXCR4 axis, which leads to the initiation of downstream ERK signaling pathway. As suggested by further RNA sequencing analysis, the high IFI6 level in MSCs somewhat influenced the gene expression profile and biological functions of leukemia cells. Conclusions BM-MSCs in the leukemia niche have varying degrees of changes in biological characteristics and gene expression profiles. Overexpression of IFI6 in BM-MSCs could be a key factor in promoting the proliferation of B-ALL cells, and this effect might be exerted through the SDF-1/CXCR4/ERK signal stimulation. Targeting IFI6 or related signaling pathways might be an important measure to reduce the leukemia cell proliferation.

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Remission Rate Of Acute Lymphoblastic Leukemia (all) In Adolescents And Young Adults (aya)

Abstract: The remission induction rate was 70.7% in the adolescents and young adults with acute lymphoblastic leukemia at the study centre.

Cited by 4 publications

References 1 publication

A Rare Acute Lymphoblastic Leukemia in a Patient Infected with Epstein-Barr Virus: A Case Report

A Rare Acute Lymphoblastic Leukemia in a Patient Infected with Epstein-Barr Virus: A Case Report

Reticulocyte Count and Platelet Count as Predictors of Morphological Remission/Hemopoitic Recovery in Acute Lymphoblastic Leukemia (ALL) after Induction Chemotherapy

BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6

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