Remission of persistent childhood asthma: Early predictors of adult outcomes

Wang, Alberta L.; Datta, Soma; Weiss, Scott T.; Tantisira, Kelan G.

doi:10.1016/j.jaci.2018.09.038

Cited by 44 publications

(52 citation statements)

References 30 publications

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“…In our article on childhood asthma remission from the Childhood Asthma Management Program (CAMP) cohort, 1 we identified predictors of both asthma remission and persistence into adulthood. The predicted probability of asthma remission was the highest (82.6%) in subjects with a baseline FEV 1 to forced vital capacity (FEV 1 /FVC) ratio of greater than or equal to 85%, provocative concentration causing a 20% fall in FEV 1 (PC 20 ) of greater than or equal to 1 mg/mL, and serum eosinophil count of less than 500 cells/mL.…”

Section: Replymentioning

confidence: 99%

“…I read with interest the recent article by Ito et al 1 The authors reported that only 2 of 15 patients with skin eruptions after eradication therapy for Helicobacter pylori using amoxicillin, clarithromycin, and a proton pump inhibitor had positive results on repeated drug lymphocyte transformation tests (LTTs), and in another patient CD4 1 T cells expressed CD154 in response to the drugs. They elegantly demonstrated that a significant proportion of the patients with negative drug-specific responses (9/12) exhibited H pylori-specific immune responses.…”

Section: Amoxicillin Sensitization Rate In Patients With Eruptions Afmentioning

confidence: 99%

“…They elegantly demonstrated that a significant proportion of the patients with negative drug-specific responses (9/12) exhibited H pylori-specific immune responses. 1 Table I summarizes 11 patients with skin eruptions after H pylori eradication therapy in our hospital during the last 3 years. Similar with the previous studies, 1,2 in most patients generalized maculopapular rash developed after completing the 7-day eradication therapy (Table I).…”

Section: Amoxicillin Sensitization Rate In Patients With Eruptions Afmentioning

confidence: 99%

“…1 Table I summarizes 11 patients with skin eruptions after H pylori eradication therapy in our hospital during the last 3 years. Similar with the previous studies, 1,2 in most patients generalized maculopapular rash developed after completing the 7-day eradication therapy (Table I). In our patients, however, all but 1 exhibited positive LTT responses to amoxicillin (Table I).…”

Section: Amoxicillin Sensitization Rate In Patients With Eruptions Afmentioning

confidence: 99%

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Wang

Tantisira

2019

Journal of Allergy and Clinical Immunology

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Section: Replymentioning

confidence: 99%

Section: Amoxicillin Sensitization Rate In Patients With Eruptions Afmentioning

confidence: 99%

Section: Amoxicillin Sensitization Rate In Patients With Eruptions Afmentioning

confidence: 99%

Section: Amoxicillin Sensitization Rate In Patients With Eruptions Afmentioning

confidence: 99%

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Wang

Tantisira

2019

Journal of Allergy and Clinical Immunology

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“…In a previous study, we found that higher fitness was associated with decreased asthma morbidity in adolescent males 14 . Understanding relationships between asthma, aerobic fitness, and sedentary time in young children are critical because the clinical trajectory of childhood asthma has important implications for management, prognosis, and overall health 15,16 . To the best of our knowledge, there are currently no studies evaluating the relationships between asthma, obesity, and aerobic fitness in children less than 9 years of age.…”

Section: Introductionmentioning

confidence: 99%

Low fitness and increased sedentary time are associated with worse asthma—The National Youth Fitness Survey

Forno

Radom‐Aizik

2020

Pediatric Pulmonology

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Background Asthma is the most common chronic illness in children and is independently impacted by obesity and by fitness. The National Youth Fitness Survey collected data on aerobic fitness, body composition, and health outcomes in children 6 to 11 years old. The goal of this study is to test hypotheses regarding relationships between asthma, aerobic fitness, and sedentary time in this uniquely studied cohort of young children. Methods A total of 665 children (6‐11 years old; 49% male) were included in analyses. We explored relationships between asthma outcomes and aerobic fitness (measured by endurance time), self‐reported sedentary time, and body mass index categories. Fitness was categorized as unfit (lowest 25% of endurance times) or fit. Multivariate logistic regression models were created for asthma outcomes and adjusted for race, age, sex, poverty status, and overweight/obesity. Results Among the participants, 17.9% had a previous history of asthma and 11.4% had current asthma. Additionally, 37.3% of participants were overweight or obese. Low fitness was significantly associated with increased odds of past asthma, current asthma, asthma attacks, wheeze with exercise, and wheeze with activity limitations in multivariate models. Increased sedentary time was significantly associated with increased odds of previous asthma, current asthma, asthma attacks, and wheeze with activity limitations. Conclusion Decreased aerobic fitness and increased sedentary time were associated with worse asthma outcomes in this group of children (6‐11 years old). This data suggest that fitness and sedentary time, both modifiable factors, each have an independent effect on asthma and should be included in assessments and management of asthma health.

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Probability of successful inhaled corticosteroids cessation in preschool wheezers: a predictive score

et al. 2022

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Nearly all asthma predictive tools estimate the future risk of asthma development. However, there is no tool to predict the probability of successful ICS cessation at an early age. Therefore, we aimed to determine the predictors of successful ICS cessation in preschool wheezers, and developed a simple predictive tool for clinical practice. MethodsThis was a retrospective cohort study involving preschool wheezers who had undergone an ICS therapeutic trial during 2015-2020 at the University Hospital, Southern, Thailand. A predictive scoring system was developed using a nomogram to estimate the probability of successful ICS cessation. We calculated area under ROC curve and used a calibration plot for assessing the tool's performance. ResultsA total of 131 medical records were eligible for analysis. Most of the participants were male (68.9%).More than half of the preschool wheezers had successful ICS cessation after an initial therapeutic trial regimen. The predictors of successful ICS cessation were perinatal oxygen use [OR 0.10 (0.01, 0.70), P = 0.02], allergic rhinitis [OR 0.20 (0.08, 0.56), P = 0.002], blood eosinophil count > 500 cell/mm 3 [OR 0.20 (0.06, 0.67), P = 0.008], and previous ICS use > 6 months [OR 0.30 (0.09, 0.72), P = 0.009]. ConclusionsPredictors of successful ICS cessation were: no perinatal oxygen use, no allergic rhinitis, blood eosinophil count < 500 cell/mm 3 , and previous ICS use < 6 months. A simple predictive score developed in this study may help general practitioners to be more con dent in making a decision regarding the discontinuation of ICS after initial therapeutic trials.

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Remission of persistent childhood asthma: Early predictors of adult outcomes

Cited by 44 publications

References 30 publications

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Low fitness and increased sedentary time are associated with worse asthma—The National Youth Fitness Survey

Probability of successful inhaled corticosteroids cessation in preschool wheezers: a predictive score

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