Remission of active diabetic hepatitis after correction of hyperglycemia

Tak, Paul P.; Kate, Fiebo J.W. ten

doi:10.1111/j.1600-0676.1993.tb00628.x

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Excessive liver glycogen content is considered a diabetic complication [31] related to adaptive changes to insulin absence, hyperglycemia and enhanced gluconeogenesis [5]. This complication can be corrected by glycemic control [32,33].…”

Section: Discussionmentioning

confidence: 99%

Glutamine or Glutamine Dipeptide Supplementation Improves Gluconeogenesis and Liver Glycogenosis in Type 1 Diabetic Rats

Azevedo¹,

Rosa²,

Wunderlich³

et al. 2019

JPP

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The effects of the supplementation with L-glutamine (GLN) or L-alanyl-L-glutamine (GDP) on the progression of the systemic and hepatic metabolic status of rats having untreated type 1 diabetes mellitus (T1DM) were investigated. Male Wistar diabetic rats (streptozotocin, 60 mg/kg) were allotted to four groups supplemented by gavage for thirty days as follows: control and diabetic receiving saline; diabetic receiving GLN (248 mg/kg); and diabetic receiving GDP (400 mg/kg). Body weight, plasmatic parameters and kidney function were analyzed. Isolated hepatocytes were used to assess gluconeogenic capacity. Liver and kidney were used for morphological analyses. T1DM decreased the number and increased the area of the hepatocytes, possibly because of the observed enlargement of glycogen stores. Kidney weight, glomerular area and proteinuria increased, and glomerular filtration rate decreased, in non-supplemented T1DM rats. Glomerular area and proteinuria were reversed by both supplementations. The T1DM hepatocytes released less glucose, which could have been diverted to glycogen synthesis and secondary glycogenosis observed in T1DM; this was partially reversed by the supplementations. The results point to a possible beneficial effect of glutamine on the metabolic and hepatic impairments of T1DM.

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Section: Discussionmentioning

confidence: 99%

Glutamine or Glutamine Dipeptide Supplementation Improves Gluconeogenesis and Liver Glycogenosis in Type 1 Diabetic Rats

Azevedo¹,

Rosa²,

Wunderlich³

et al. 2019

JPP

View full text Add to dashboard Cite

show abstract

“… The clinical (abdominal pain, hepatomegaly), biological (increased transaminase blood level), and histological features are consistent with recurrent acute steatosis. Enlargement of the liver may be so important and fast that it causes abdominal pain and particularly high hypertransaminasemia (1,4,6). The hepatomegaly described in this case can easily be distinguished from that seen in Nobecourt and Mauriac's syndromes by the absence of growth retardation and faciotroncular obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Tak and Kate explained the hepatomegaly and liver function features by the high insulin blood level in the portal vein (both endo‐ and exogenous insulin), which may promote the esterification of fatty acid into triglycerides and intracellular lipid accumulation (ballooned hepatocytes), because triglyceride synthesis simply exceeds the capacity of the liver to secrete newly formed triglycerides as very low‐density lipoprotein. With improvement of diabetes status and decreased insulin level in the portal vein, there may be decreased esterification of fatty acids (6).…”

Section: Discussionmentioning

confidence: 99%