Remission from substance use disorders: A systematic review and meta-analysis

Fleury, Marie‐Josée; Djouini, Akram; Huỳnh, Christophe; Tremblay, Joël; Ferland, Francine; Ménard, Jean‐Frédéric; Belleville, Geneviève

doi:10.1016/j.drugalcdep.2016.08.625

Cited by 146 publications

(96 citation statements)

References 84 publications

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“…In US general population surveys, the prevalence of recovery from AUD ranged from 54.0 to 72.2% (Dawson, ; Dawson et al., ; Hasin et al., ; Robin and Regier, ). The average recovery rate reported in community studies between 1868 and 2011 was 53.9% (White, ), similar to the rates of recovery (35.0 to 54.4%) in follow‐up studies conducted from 2000 to 2015 (Fleury et al., ). In some of these studies (De Bruijn et al., ; Hasin et al., ; Rumpf et al., ; Schuckit et al., ), recovery was defined as no longer meeting diagnostic criteria for AUD (usually in the past year) and in terms of abstinence outcomes.…”

supporting

confidence: 69%

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Prevalence and Correlates of Past‐Year Recovery From DSM‐5 Alcohol Use Disorder: Results From National Epidemiologic Survey on Alcohol and Related Conditions‐III

Fan

Chou

Zhang

et al. 2019

Alcoholism Clin & Exp Res

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Background:Little is known about remission, recovery, and other outcomes of alcohol use disorder (AUD) as defined by the DSM-5.Methods: Data from a large representative sample of the United States was used to examine correlates of past-year AUD status among individuals with prior-to-past-year AUD: persistent AUD, symptomatic high-risk drinking, asymptomatic high-risk drinking, symptomatic low-risk drinking, asymptomatic low-risk drinking (nonabstinent recovery, NAR), and abstainer (abstinent recovery, AR). Multiple logistic regression analyses were conducted to compare: (i) AR and NAR with persistent AUD, (ii) AR with NAR, and (iii) asymptomatic and symptomatic high-risk drinking with AR and NAR.Results: Among individuals with AUD prior to past year (n = 7,785), 34.2% were classified with persistent AUD, 8.8 and 1.6% were symptomatic high-risk and symptomatic low-risk drinkers, respectively, 21.5% were asymptomatic high-risk drinkers, 17.9% were asymptomatic low-risk drinkers, and 16.0% were abstainers. One-quarter of individuals with AUD prior to past year achieved AR or NAR without the benefit of treatment, while a much greater percentage of individuals achieving AR (43.2%) reported receiving treatment relative to those with NAR (12.3%). The number of lifetime AUD symptoms was greater among those achieving AR (among the treated) and lower among those achieving NAR relative to persistent AUD. The number of AUD symptoms was also greater among those achieving AR than NAR and lower among asymptomatic and symptomatic risk drinkers relative to those achieving AR and NAR. Consumption was greater among those achieving AR relative to those achieving NAR and greater among asymptomatic and symptomatic risk drinkers relative to AR and NAR. Odds of achieving AR or NAR relative to persistent AUD were generally lower among non-Hispanic Blacks and those with higher education, greater among women and married individuals, and lower among illicit drug users and individuals with histories of a personality disorder or mood/anxiety disorder.Conclusions: There appears to be a substantial level of recovery from AUD. Information on specific factors associated with AUD outcomes can be useful in targeting appropriate treatment efforts.

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supporting

confidence: 69%

“…In the context of high AUD morbidity and mortality, numerous studies have sought to document rates of recovery and factors that promote or impede the recovery process (Fleury et al., ; White, ). In US general population surveys, the prevalence of recovery from AUD ranged from 54.0 to 72.2% (Dawson, ; Dawson et al., ; Hasin et al., ; Robin and Regier, ).…”

mentioning

confidence: 99%

Prevalence and Correlates of Past‐Year Recovery From DSM‐5 Alcohol Use Disorder: Results From National Epidemiologic Survey on Alcohol and Related Conditions‐III

Fan

Chou

Zhang

et al. 2019

Alcoholism Clin & Exp Res

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“…The appropriate lag structure between admissions to specialty substance abuse treatment and the state unemployment rate in not obvious. Moreover, the lag structure may vary across substances given differences in potential for addiction, harms associated with abuse, types of individuals who abuse substances, capacity constraints of providers who deliver care, and so forth (Dennis et al 2005;Fleury et al 2016;Kessler et al 2001;Lopez-Quintero et al 2011;Nosyk et al 2014). In our main specification, we 4.…”

Section: Methodsmentioning

confidence: 99%

Business Cycles and Admissions to Substance Abuse Treatment

Maclean

Horn

Cantor

2019

Contemporary Economic Policy

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We study the effect of business cycles on admissions to specialty substance abuse treatment using administrative data between 1992 and 2015. We proxy business cycles with the state unemployment rate and apply a panel fixed‐effects model. While previous economic research has shown that substance abuse is counter‐cyclical, we observe no change in the total number of admissions across the business cycle. However, focusing on average effects misses important heterogeneity. In substance‐specific regressions we find statistically significant evidence that heroin‐related admissions are counter‐cyclical while stimulant‐related admissions are procyclical. Our findings add to the literature on business cycles and health. (JEL I1, J2)

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“…However, there is still a lack of preclinical data exploring the possible effect of pain on ethanol relapse related behaviors. Relapse constitutes a major obstacle for AUDs treatments, hence at most 50% of treated people do not achieve remission after long follow up periods [10]. Moreover, and as previously mentioned, clinical studies have shown that the correct management of the pain situation resulting in decreases in pain levels are associated with lower risk of alcohol relapse [15].…”

Section: Introductionmentioning

confidence: 99%

Effect Of Inflammatory Pain On Alcohol-Induced Dopamine Release In The Nucleus Accumbens: Behavioural Implications In Rat Models

Lorente¹,

González-Romero²,

Granero³

et al. 2019

Preprint

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Recent studies have drawn the attention to the link between Alcohol Use Disorder (AUD) and the presence of pain. Indeed, the correct management of pain in patients with a previous history of AUD has been reported to decrease the risk of relapse in alcohol drinking, suggesting that in this prone population, pain may increase the vulnerability to relapse. Previous data in male rats revealed that inflammatory pain desensitizes mu opioid receptors (MORs) in the ventral tegmental area (VTA) and increases intake of high doses of heroine. Due to the relevant role of MORs in alcohol effects, we hypothesize that pain may also alter alcohol reinforcing properties and therefore affect alcohol relapse in male rats. Our microdialysis studies show that the presence of inflammatory pain blunted the increase of extracellular dopamine levels in the Nucleus Accumbens induced by 1.5g/kg of ethanol (s.c.). Moreover, we also revealed that the administration of 52 nmol of ethanol into the VTA failed to induce place preference only in inflammatory pain-suffering animals, and a higher dose (70nmol) was necessary to reverse this effect. Finally, we evaluated the effect of inflammatory pain on the alcohol deprivation effect (ADE) in longterm ethanol-experienced male rats. After four cycles of free ethanol intake and abstinence periods, inflammatory pain induced ADE without affecting its magnitude. These intriguing data reveals the impact of pain on neurochemical and behavioral effects following alcohol administration but also underscore the necessity of finding an appropriate paradigm to determine the long-term behavioral consequences.

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Remission from substance use disorders: A systematic review and meta-analysis

Cited by 146 publications

References 84 publications

Prevalence and Correlates of Past‐Year Recovery From DSM‐5 Alcohol Use Disorder: Results From National Epidemiologic Survey on Alcohol and Related Conditions‐III

Prevalence and Correlates of Past‐Year Recovery From DSM‐5 Alcohol Use Disorder: Results From National Epidemiologic Survey on Alcohol and Related Conditions‐III

Business Cycles and Admissions to Substance Abuse Treatment

Effect Of Inflammatory Pain On Alcohol-Induced Dopamine Release In The Nucleus Accumbens: Behavioural Implications In Rat Models

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