Remisión espontánea de un linfoma no Hodgkin plasmablástico asociado a metotrexato tras disminución de la dosis del fármaco

García‐Noblejas, Ana; Velasco, Alberto; Cannata-Ortiz, Jimena; Arranz, Reyes

doi:10.1016/j.medcli.2012.10.001

Cited by 7 publications

(1 citation statement)

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“…In contrast to our case, three previously reported cases of PBL showing spontaneous regression were clearly associated with a specific immunodeficiency (e.g., HIV infection [ 10 , 11 ] and methotrexate administration [ 12 ]). The spontaneous regression in these cases may be related to the patient’s restoration of immune function secondary to anti-HIV treatment or reduced dosage of an immunosuppressive agent.…”

Section: Discussioncontrasting

confidence: 99%

Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient

et al. 2015

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Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.

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Section: Discussioncontrasting

confidence: 99%