Remineralization of early enamel caries lesions induced by bioactive particles: An in vitro speckle analysis

Sfalcin, Ravana Angelini; Silva, João Vagner Pereira da; Pessoa, Victória Oliva; Santos, Jennifer; Olivan, Silvia Regina Garcia; Fernandes, Kristianne Porta Santos; Deana, Alessandro Melo; Makeeva, Irina; Sauro, Salvatore; Bussadori, Sandra Kalil

doi:10.1016/j.pdpdt.2019.07.022

Cited by 6 publications

(2 citation statements)

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“…In conclusion, this novel approach to the study of enamel in vivo, could be applied to evaluate the responsiveness to remineralizing infiltrating agents, as well as to image in vivo the dental restoration interface, the margins of infiltrations, the duration and the deterioration of the compounds, and/or for longitudinal evaluation of non-invasive methods for white spot lesions arrestment, without the need for working on extracted and processed teeth, supporting and supported by the previous evidence of in vitro studies [18][19][20][21].…”

Section: Discussionsupporting

confidence: 54%

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Real Time In Vivo Confocal Microscopic Analysis of the Enamel Remineralization by Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP): A Clinical Proof-of-Concept Study

et al. 2020

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Enamel defects (EDs) are qualitative and/or quantitative disturbances of the dental surface. To date, the responsiveness to remineralizing treatments has been studied ex vivo, on dental sections from extracted teeth. The present research aims to establish if in vivo reflectance confocal laser scanning microscopy is able to visualize the changes in the enamel architecture on living teeth, before, during and after remineralizing treatments by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). As proof-of-concept study, 17 consecutive children affected by EDs were enrolled and 38 EDs were considered. A CPP-ACP mousse was applied twice a week for 6 weeks and clinical and microscopic images were collected before, during and after the treatment for evaluating the changes occurred. For in vivo microscopic imaging, a reflectance confocal laser scanning microscope (RCM) for in vivo use was adopted. In this study RCM was proven to be able to visualize in vivo and at microscopic resolution the changes occurred during the remineralizing processes without needing for dental extractions and histopathological procedures. This in vivo RCM capability could encourage its clinical application in monitoring responsiveness to enamel therapies.

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Section: Discussionsupporting

confidence: 54%

“…To date, all these processes and the dental microscopic architecture before, during and after the use of these biomimetic compounds, have been studied in vitro, mainly by transverse microradiography, scanning electron microscopy and confocal microscopy on dental sections of specimens from extracted teeth [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%