Remembering the past with slow breathing associated with activity in the parahippocampus and amygdala

Masaoka, Yuri; Sugiyama, Haruko; Katayama, Atsushi; Kashiwagi, Mitsuyoshi; Homma, Ikuo

doi:10.1016/j.neulet.2012.05.047

Cited by 31 publications

(43 citation statements)

References 24 publications

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“…These inspiration-related olfactory potentials are referred to as inspiration phase-locked alpha band oscillations (I-alpha). On the basis of EEG dipole modeling (EEG/DT), the neural substrates of early I-alpha signals were isolated to primary olfactory areas, including the ENT, AMG, HI, while subsequent activity was localized to secondary olfactory areas within the OFC (Masaoka et al, 2005(Masaoka et al, , 2012. These findings supported the neural cascade model of olfactory processing leading from primary olfactory regions to core limbic structures, and then subsequently, prefrontal cortex.…”

Section: Introductionmentioning

confidence: 55%

“…neural activation of the olfactory circuit during odor perception in both animals (Cury and Uchida, 2010;Shusterman et al, 2011) and humans (Sobel et al, 1998;Masaoka et al, 2005Masaoka et al, , 2012. Second, primary olfactory areas in the brain exist outside of the cerebral cortex, and the neural pathways that subserve olfactory processes bypass the thalamus and ascend directly to olfactory-limbic areas (Yeshurun and Sobel, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The ENT provides a subsequent gateway to the hippocampal formation (HI) (Ramus and Eichenbaum, 2000). This "neural cascade" is hypothesized to directly link olfactory perception with emotional salience processing in the AMG and memory systems in the ENT and HI (Masaoka et al, 2005(Masaoka et al, , 2012. Outputs from ENT and AMG subsequently converge on the OFC where higher-order processing takes place, including smell identification and emotional labeling (Rolls, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Outputs from ENT and AMG subsequently converge on the OFC where higher-order processing takes place, including smell identification and emotional labeling (Rolls, 2001). Taking advantage of the time-locked nature of inspiration and olfaction, we have previously investigated the in vivo spatiotemporal profile of olfactory processing in the human brain (Masaoka et al, 2005(Masaoka et al, , 2012. By simultaneously recording electroencephalography (EEG) and respiration during odor perception, we have identified olfactory potentials associated with the onset of inspiration.…”

Section: Introductionmentioning

confidence: 99%

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The neural cascade of olfactory processing: A combined fMRI–EEG study

Masaoka

Harding

Koiwa

et al. 2014

Respiratory Physiology & Neurobiology

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Olfaction is dependent on respiration for the delivery of odorants to the nasal cavity. Taking advantage of the time-locked nature of inspiration and olfactory processing, electroencephalogram dipole modeling (EEG/DT) has previously been used to identify a cascade of inspiration-triggered neural activity moving from primary limbic olfactory regions to frontal cortical areas during odor perception. In this study, we leverage the spatial resolution of functional magnetic resonance imaging (fMRI) alongside the temporal resolution of EEG to replicate and extend these findings. Brain activation identified by both modalities converged within association regions of the orbitofrontal cortex that were activated from approximately 150-300 ms after inspiration onset. EEG/DT was additionally sensitive to more transient activity in primary olfactory regions, including the parahippocampal gyrus and amygdala, occurring approximately 50 ms post-inspiration. These results provide a partial validation of the spatial profile of the olfactory cascade identified by EEG source modeling, and inform novel future directions in the investigation of human olfaction.

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Section: Introductionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The neural cascade of olfactory processing: A combined fMRI–EEG study

Masaoka

Harding

Koiwa

et al. 2014

Respiratory Physiology & Neurobiology

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“…However, olfactory stimulation activates many brain areas, such as the hippocampus, which is related to memory, the visual field, which is caused by a special memory induced by olfactory stimuli, and the motor cortex, which is activated by voluntary breathing during smelling 17 . Based on these wide areas of activation by olfactory stimulation, we propose that it might be possible to use olfactory stimulation in the rehabilitation of CP patients to improve cognitive abilities.…”

Section: Clinical Care and Rehabilitation In Cp Patientsmentioning

confidence: 99%

Olfactory Response in Patients with Cerebral Palsy: Investigation of the Possible Use of Olfactory Testing to Evaluate Patients and Reduce Anxiety of Their Parents

Hanaoka

Masaoka

Akai

et al. 2013

Showa Univ J Med Sci

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: Cerebral palsy CP is a developmental disorder associated with lifelong motor impairment and disability. Several studies have investigated the effects of CP on sensory responses, but there has been no research on olfactory function in CP. This study had two specific aims. First, by observing respiratory responses which serve as an index for the ability to detect and recognize odors, we aimed to estimate the patients ability to distinguish pleasant from unpleasant odors. These responses can also indicate the capacity for an emotional response to pleasant or unpleasant stimuli. Second, we aimed to investigate the psychological response in the parents as they observed the respiratory response in their children during the odor test. Parents were assessed with the Spielberger State-Trait Anxiety Inventory STAI to measure their state anxiety levels before and after they had observed their children being tested. In patients with CP, respiratory rate RR significantly decreased during pleasant odor stimuli P 0.05 . There was a significant increase in RR during the presentation of the unpleasant odor P 0.05 . All the CP patients showed respiratory changes in response to both pleasant and unpleasant smells, and we found that the parents anxiety levels decreased after the test. We intend to develop this olfactory test technique to contribute to the neurological rehabilitation for CP patients and to reduce anxiety of their parents.

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Neural Correlates of Autobiographical Memory

Jacques¹,

Brigard²

2015

The Wiley Handbook on the Cognitive Neuroscience of Memory

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Remembering the past with slow breathing associated with activity in the parahippocampus and amygdala

Cited by 31 publications

References 24 publications

The neural cascade of olfactory processing: A combined fMRI–EEG study

The neural cascade of olfactory processing: A combined fMRI–EEG study

Olfactory Response in Patients with Cerebral Palsy: Investigation of the Possible Use of Olfactory Testing to Evaluate Patients and Reduce Anxiety of Their Parents

Neural Correlates of Autobiographical Memory

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