Remedial effects of casticin as an antioxidant on cisplatin induced oxidative damage in rat liver

Ijaz, Muhammad Umar; Ashraf, Asma; Ahmed, Aqsa; Ismail, Hammad; Muzzamil, Saima; Samad, Abdul; Al‐Ghanim, Khalid A.; Al‐Misned, Fahad A.; Ahmed, Zubair; Mahboob, Shahid

doi:10.1016/j.jksus.2019.10.009

Cited by 13 publications

(5 citation statements)

References 30 publications

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“…The release of the ALP and aminotransferase liver enzymes from the cytosol to the systemic circulation indicated the derangement in the liver cell membrane integrity and this matched with several studies in which after CP injection, a marked increase in serum ALT, AST, and ALP levels were documented confirming liver injury. [ 31–33 ] Moreover, liver tissue after CP injection showed congestion in the portal blood vessels, dilated sinusoids, hydropic degeneration in hepatocytes, portal edema, and leukocytic cells infiltration, and these histopathological findings were in line with other previous studies. [ 6,31 ]…”

Section: Discussionsupporting

confidence: 89%

“…[ 31–33 ] Moreover, liver tissue after CP injection showed congestion in the portal blood vessels, dilated sinusoids, hydropic degeneration in hepatocytes, portal edema, and leukocytic cells infiltration, and these histopathological findings were in line with other previous studies. [ 6,31 ]…”

Section: Discussionsupporting

confidence: 87%

“…Extensive research established the use of natural products in ameliorating the hepatotoxicity induced by CP through the reduction of serum levels of ALT, AST, and ALP in addition to the improvement of the histopathological pictures of the liver. [ 31–33 ] Arj, in the same way, showed a significant reduction in the liver enzymes tested and also refined markedly the architecture of the liver compared to the liver histopathological findings observed with CP.…”

Section: Discussionmentioning

confidence: 55%

“…[ 8 ] It is well known that CP causes reactive oxygen species (ROS) production leading to oxidative damage to the biological molecules like DNA, proteins, and lipids [ 31,34 ] therefore, the antioxidant defense system is crucial in facing oxidative stress produced and defending the cell from the dangerous effects of ROS and oxidative damage. [ 31 ] In this context, CP induced a marked rise in hepatic MDA and NO contents along with a marked decline of the antioxidant enzymes like SOD and CAT as well as the nonenzymatic antioxidant GSH hepatic levels and several studies agreed with the results of this study. [ 32,34,35 ]…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis

Sherif

2021

J Biochem & Molecular Tox

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Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to highlight the possible hepatoprotective role of arjunolic acid (Arj) in a rat model of CP‐induced hepatotoxicity. Four groups of rats were included; the normal control group, Arj control group, CP group which was injected with 7.5 mg/kg CP intraperitoneally to induce hepatotoxicity, and the treated group (Arj + CP), which was orally administered 20 mg/kg Arj for 10 days with a CP hepatotoxic dose on day 5. Blood and liver tissues were assembled for analysis at the end of the study. Pretreatment with Arj exhibited a marked improvement in liver function as well as histopathology when compared with the CP group. Moreover, Arj suppressed the oxidative stress in hepatic tissue by significantly decreasing malondialdehyde and nitric oxide contents along with markedly elevating the levels of superoxide dismutase, catalase, and reduced glutathione when compared with CP injected rats. Attenuation of hepatic inflammation and apoptosis was also reported with Arj treatment through the marked reduction in the proinflammatory cytokine tumor necrosis factor α level as well as the apoptotic marker caspase‐3 protein expression in comparison to the CP group. This study explored for the first time the Arj hepatoprotective effect against CP‐induced hepatotoxicity through its antioxidant, anti‐inflammatory, and antiapoptotic activities.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis

Sherif

2021

J Biochem & Molecular Tox

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“…The generated ROS allow the oxidative damage of the biological components, including DNA, proteins, and lipids. Thus, the antioxidant defense system is vital to counter oxidative stress and preserving the cell from the potentially harmful consequences of ROS and oxidative impairment [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways

Bekhit,

Beshay,

Fawzy

et al. 2023

Stem Cells International

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Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore the protective impact of azilsartan (AZIL), an antihypertensive drug, in addition to adipose tissue-derived mesenchymal stem cells (AD-MSCs) on CISP-induced hepatotoxicity. After characterization and labeling of AD-MSCs by PKH26 dye, 54 Wistar male albino rats were randomly divided into nine groups: I (CONT), II (AZIL.H), III (CISP), IV (CISP + AZIL.L), V (CISP + AZIL.H), VI (CISP + AD-MSCs), VII (CISP + AZIL.L + AD-MSCs), VIII (CISP + AZIL.H + AD-MSCs), and IX (CISP + VITA C). Serum alanine aminotransferase (ALT), alanine aminotransferase (AST), and albumin levels were determined. Assessment of reactive oxygen species, malondialdehyde, and glutathione contents, and superoxide dismutase activity and histopathological evaluations were done on hepatic tissue. Quantitative real-time PCR was utilized to estimate the expression of TNF-α and IL-6 genes. Cell homing of labeled AD-MSCs to the liver tissues was investigated. Hepatic expression of JNK1/2, ERK1/2, p38, Bax, Bcl-2, and cleaved caspase-3 proteins was investigated by western blot analysis. CISP elevated serum ALT and AST activities, reduced albumin level, and remarkably changed the hepatic architecture. It increased the expression TNF-α and IL-6 genes, raised the expression of JNK1/2, ERK1/2, p38, Bax, and cleaved caspase-3 proteins, and diminished the Bcl-2 protein. By contrast, treatment of animals with either AZIL or AD-MSCs dramatically reduced the effects of CISP injection. Moreover, treatment with combination therapy (AZIL.L or H + AD-MSCs) considerably mitigated all previously mentioned alterations superior to AZIL or AD-MSCs alone, which might be attributed to the AZIL-enhanced homing ability of AD-MSCs into the injured liver tissue. In conclusion, the present findings demonstrated that AZIL improves the hepatoprotective potential of AD-MSCs against CISP-induced hepatotoxicity by modulating oxidative stress, mitogen-activated protein kinase, and apoptotic pathways.

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Analyzing the Chemical Constituents and In Vitro Biological Effects of Extracts Artemisia absinthium L. Extracts Obtained Using Different Methodologies and Solvents

Yagi,

Zengin,

Ibrahime Sinan

et al. 2024

Chemistry & Biodiversity

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The present study aimed to investigate the chemical constituents of different extracts from aerial parts of A. absinthium and to evaluate their antioxidant and enzyme inhibition activity. Extracts were prepared by maceration, infusion or Soxhlet techniques. Results showed that the highest total phenolic and flavonoids contents was recorded respectively from the hexane extract prepared by maceration and ethyl acetate extract obtained by Soxhlet method. The characteristic compounds of Artemisia species artemetin, casticin, sesartemin and yangambin in addition to coumarins were identified in all extracts. Aqueous extract obtained by infusion exerted the highest radical scavenging and ions reducing properties while that prepared by maceration displayed the highest chelating power. Methanol extracts obtained by the two methods of extraction exerted the highest anti‐Tyr activity while that obtained by maceration showed the best α‐glucosidase inhibition activity. These findings indicated that A. absinthium is a rich source of bioactive molecules with possible therapeutic applications.

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Remedial effects of casticin as an antioxidant on cisplatin induced oxidative damage in rat liver

Cited by 13 publications

References 30 publications

Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis

Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis

Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways

Analyzing the Chemical Constituents and In Vitro Biological Effects of Extracts Artemisia absinthium L. Extracts Obtained Using Different Methodologies and Solvents

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