Remedia Sternutatoria over the Centuries: TRP Mediation

Aloum, Lujain; Alefishat, Eman; Shaya, Janah; Petroianu, Georg

doi:10.3390/molecules26061627

Cited by 3 publications

(4 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ligands at these receptors act from the intracellular side. The best-known activators of TRPV1 are temperature greater than 43°C (109°F), hydrogen ions, capsaicin, allyl isothiocyanate (mustard oil) and resiniferatoxin ( Aloum et al, 2021 ).…”

Section: Clinically Available Drugsmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On one hand the mandate of primum non nocere, on the other hand, the promise of heavenly joys if successful divinum est opus sedare dolorem. We briefly summarize the concepts associated with nociceptive pain from nociceptive input (afferents from periphery), modulatory output [descending noradrenergic (NE) and serotoninergic (5-HT) fibers] to local control. The local control is comprised of the “inflammatory soup” at the site of pain origin and synaptic relay stations, with an ATP-rich environment promoting inflammation and nociception while an adenosine-rich environment having the opposite effect. Subsequently, we address the transition from nociceptor pain to neuropathic pain (independent of nociceptor activation) and the process of sensitization and pain chronification (transient pain progressing into persistent pain). Having sketched a model of pain perception and processing we attempt to identify the sites and modes of action of clinically available drugs used in chronic pain treatment, focusing on adjuvant (co-analgesic) medication.

show abstract

Section: Clinically Available Drugsmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…[30,31] The aliphatic chain of capsaicin forms a nonspecific van der Waals interaction with the TRPV1 receptor and contributes to the binding affinity. [32] In addition, the hydrogen bonding interactions involving the amide and vanillyl groups of Thr550 and Glu570 are essential for the specificity of the ligand binding of TRPV1. The binding affinities and binding sites of all the target compounds were compared with that of capsaicin (Figure 2f,g).…”

Section: Patch Clamp Recording and Simulation Of The Ligand Binding R...mentioning

confidence: 99%

Reusable Electronic Tongue Based on Transient Receptor Potential Vanilloid 1 Nanodisc‐Conjugated Graphene Field‐Effect Transistor for a Spiciness‐Related Pain Evaluation

et al. 2023

View full text Add to dashboard Cite

The sense of spiciness is related to the stimulation of vanilloid compounds contained in the foods. Although, the spiciness is commonly considered as the part of taste, it is more classified to the sense of pain stimulated on a tongue, namely, pungency, which is described as a tingling or burning on the tongue. Herein, first, a reusable electronic tongue based on a transient receptor potential vanilloid 1 (TRPV1) nanodisc conjugated graphene field‐effect transistor is fabricated and spiciness‐related pain evaluation with reusable electrode is demonstrated. The pungent compound reactive receptor TRPV1 is synthesized in the form of nanodiscs to maintain stability and reusability. The newly developed platform shows highly selective and sensitive performance toward each spiciness related vanilloid compound repeatably: 1 aM capsaicin, 10 aM dihydrocapsaicin, 1 fM piperine, 10 nM allicin, and 1 pM AITC. The binding mechanism is also examined by simulation. Furthermore, the elimination of the burning sensation on the tongue after eating spicy foods is not investigated. Based on the synthesis of micelles composed of casein protein (which is contained in skim milk) that remove pungent compounds bound to TRPV1 nanodisc, the deactivation of TRPV1 is investigated, and the electrode is reusable that mimics electronic tongue.

show abstract

“…17th-century England, snuff tobacco was thought to be a panacea universally good for the body. For a comprehensive review see [Aloum et al, 2021].…”

Section: Photic Sneeze Reflex Geneticsmentioning

confidence: 99%

“…Johann Bartholomäus Trommsdorff (1770-1837 writes: Dieser Stoff (Veratrin) ist weiss, und pulverig, ohne Geruch, aber in die Nase gebracht, erregt er ein heftiges Niesen, welches sehr gefährlich werden kann; schon eine sehr kleine Quantität desselben bringt diese Wirkung hervor (This white powdery substance is without odor, but placed into the nose causes a violent sneeze which can be very dangerous, as even a small amount causes this effect). in the vagal sensory nerve terminals [Aloum et al, 2021]. Photo 13.…”

Section: Pulvere Veratri (Hellebore) Albiunclassified

Photic Sneeze Reflex

Petroianu¹

2022

AHS

Self Cite

View full text Add to dashboard Cite

Sternutatio (sneeze) is a poorly understood polysynaptic physiologic reflex phenomenon; even less understood are some variations of the reflex such as the photic sneeze (photo-sternutatory reflex), sneezing induced by bright light, sneezing induced by overeating, sneezing induced by plucking of the eyebrows (palpebro-sternutatory reflex) and paroxysmal sneezing, episodes of intractable sneezing. The present contribution reviews various aspects of the patho-physiology of sneezing, its relationship to singultus (hiccup) and the mechanism of action of various remedia sternutatoria (sneeze inducing agents).The manuscript deals with the history of a previously largely ignored condition and with the people involved in the matter: biographical aspects of little known clinicians and researchers such as Jean Sedan, Harry Shilkret, and Mo Shokeir are presented.

show abstract

Remedia Sternutatoria over the Centuries: TRP Mediation

Cited by 3 publications

References 137 publications

Neuropathic pain: Mechanisms and therapeutic strategies

Neuropathic pain: Mechanisms and therapeutic strategies

Reusable Electronic Tongue Based on Transient Receptor Potential Vanilloid 1 Nanodisc‐Conjugated Graphene Field‐Effect Transistor for a Spiciness‐Related Pain Evaluation

Photic Sneeze Reflex

Contact Info

Product

Resources

About