Remdesivir as a possible therapeutic option for the COVID-19

Al‐Tawfiq, Jaffar A.; Al-Homoud, Ali H.; Memish, Ziad A.

doi:10.1016/j.tmaid.2020.101615

Cited by 326 publications

(356 citation statements)

References 10 publications

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“…These drugs can compete with NTP for the binding site of RdRp and hence can induce RdRp inhibition. Due to the safety profile for these drugs (approved by the FDA before for other viruses or microbes), it can be successful candidates as anti-COVID-19 possible drugs as reported earlier (Al-Tawfiq et al, 2020;Dong et al, 2020;Elfiky, 2020aElfiky, , 2020bLythgoe & Middleton, 2020). Figure 3B shows the average binding energies for the docking of the four nucleotides (blue columns), the compounds (green and yellow columns), and the negative control molecules (red columns) into SARS-CoV-2 RdRp different conformations.…”

Section: Molecular Dockingmentioning

confidence: 76%

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: anin silicoperspective

Elfiky

2020

Journal of Biomolecular Structure and Dynamics

277

264

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New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections. In this work, molecular modeling, docking, and dynamics simulations are used to build a model for the viral protein RNA-dependent RNA polymerase (RdRp) and test its binding affinity to some clinically approved drugs and drug candidates. Molecular dynamics is used to equilibrate the system upon binding calculations to ensure the successful reproduction of previous results, to include the dynamics of the RdRp, and to understand how it affects the binding. The results show the effectiveness of Sofosbuvir, Ribavirin, Galidesivir, Remdesivir, Favipiravir, Cefuroxime, Tenofovir, and Hydroxychloroquine, in binding to SARS-CoV-2 RdRp. Additionally, Setrobuvir, YAK, and IDX-184, show better results, while four novel IDX-184 derivatives show promising results in attaching to the SARS-CoV-2 RdRp. There is an urgent need to specify drugs that can selectively bind and subsequently inhibit SARS-CoV-2 proteins. The availability of a punch of FDA-approved anti-viral drugs can help us in this mission, aiming to reduce the danger of COVID-19. The compounds 2 and 3 may tightly bind to the SARS-CoV-2 RdRp and so may be successful in the treatment of COVID-19.

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Section: Molecular Dockingmentioning

confidence: 76%

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: anin silicoperspective

Elfiky

2020

Journal of Biomolecular Structure and Dynamics

277

264

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“…Chloroquine phosphate, an anti-malarial, has been shown to be useful in treating COVID-19 pneumonia (10). Remdesivir, an antiviral drug developed to treat Ebola, has been suggested to have positive effects in COVID-19 infected patients with severe respiratory disease (11). These patients developed gastrointestinal symptoms and elevated liver function tests.…”

mentioning

confidence: 99%

COVID-19 and Older Adult

Morley

Vellas

2020

The Journal of nutrition, health and aging

162

130

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“…It requires RNA-dependent-RNA polymerase to multiply its genetic material. This may provide rationale for the potential use of Remdesivir for treatment of COVID-19 and studies are, therefore, underway (Elfiky, 2020;Dong et al, 2020;Al-Tawfiq et al, 2020;Gordon et al, 2020). Ramdesivir was also used in the treatment of Ebola -virus infections (Mulangu et al, 2019;Tchesnokov et al, 2019).…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

COVID-19: A Review on Molecular Basis, Pathogenic Mechanisms, Therapeutic Aspects and Future Projections<strong> </strong>

Faiq¹,

Kumar²,

Singh³

et al. 2020

Preprint

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The SARS-CoV-2 is a recently identified positive sense single stranded RNA virus and member of the coronavirus family of viruses. It is thought to be the etiological factor for the ongoing COVID-19 pandemic. This virus is thought to have originated from bats and acquired ability of human-to-human transmission. While SARS-CoV-2 is relatively benign, it has infected more than half a million people (as of March 29 th 2020) worldwide and the number of infected people continues to rise. More than 170 countries have reported COVID-19 positive cases. With a mortality rate of less than both the previous coronavirus outbreaks, COVID-19 has (conversely) caused the death of over 33,980 (as of 29 th March, 2020 at 22.00 hours EDT) people worldwide and the number is increasing. Given the enormous impact of this virus on human health and wellbeing and consequent devastating impacts on world trade, economics and quality of life, it is important to understand this virus better and get insight into its pathogenic mechanisms which will aid in devising effective measure to curb its spread and predict future pattern of its interaction with humans. Though very little is known about this SARS-CoV-2 but its mechanisms and patterns of spread can be speculated (with caution, nevertheless) from what we know about its closest relatives SARS-CoV-1 (responsible for SARS-2002 epidemic) and MERS-CoV (responsible for MERS-2012 epidemic). In the present review, we aim at bringing together the coherent and peer reviewed literature about the SARS-CoV-2 and its close relatives and try to understand its infection patterns and reconstruct its pathogenic mechanisms with anecdotes on diagnosis and future directions. We hope that this paper will serve the purpose of being a reliable source of information to scientists, clinicians and general public. 2020) named Huanan which was subsequently closed on January 1 st , 2020. It was later reported that individual greater than 60 years of age and those with other comorbid conditions are susceptible to severe disease and may even die (Cascella et al., 2020). The emergence of

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Remdesivir as a possible therapeutic option for the COVID-19

Cited by 326 publications

References 10 publications

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: anin silicoperspective

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: anin silicoperspective

COVID-19 and Older Adult

COVID-19: A Review on Molecular Basis, Pathogenic Mechanisms, Therapeutic Aspects and Future Projections<strong> </strong>

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