Abstract. Let L(X) be the space of bounded linear operators on the Banach space X. We study the strict singularity and cosingularity of the two-sided multiplication operators S → ASB on L(X), where A, B ∈ L(X) are fixed bounded operators and X is a classical Banach space. Let 1 < p < ∞ and p = 2. Our main result establishes that the multiplication S → ASB is strictly singular on L L p (0, 1) if and only if the non-zero operators A, B ∈ L L p (0, 1) are strictly singular. We also discuss the case where X is a L 1 -or a L ∞ -space, as well as several other relevant examples.