Remarks on Myeloid Sarcoma in Children

Gözdaşoĝlu, Sevgi

doi:10.4274/tjh.galenos.2019.2019.0002

Cited by 2 publications

(2 citation statements)

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“…White blood cell (WBC) count at diagnosis, French–American–British (FAB) immunologic subtypes, and cytogenetics are the main important prognostic factors and, thus, must be performed for all patients [ 3 , 22 ]. Studies have demonstrated that monosomal karyotypes are independent risk factors for poor prognosis, that MS patients with chromosome 8 abnormalities had a worse prognosis, and that intensive chemotherapies were needed in these groups [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is commonly associated with acute myeloid leukemia (AML) and is hence known as extramedullary manifestation of AML. MS occurs in approximately 4–5% of children with acute myeloid leukemia and may develop before, during, or after the occurrence of AML [ 2 , 3 ]. Only a few isolated cases of pediatric orbital MS have been reported, and they are often associated with a high misdiagnosis rate.…”

Section: Introductionmentioning

confidence: 99%

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Orbital myeloid sarcoma misdiagnosed for subperiostal hematoma: a case report

Razem¹,

Raiteb²,

Mrini³

et al. 2021

J Med Case Reports

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Background Myeloid sarcoma is a solid tumor that consists of immature myeloid cells occurring at an extramedullary site. It can present before, concurrent with, or after the diagnosis of acute myeloid leukemia or other myeloproliferative diseases, and a proportion of patients never develop bone marrow infiltration. Only a few isolated cases of pediatric orbital myeloid sarcoma have been reported, and they are often associated with a high misdiagnosis rate. Case report We report a rare case of pediatric orbital myeloid sarcoma associated with blunt trauma in a 3-year-old Caucasian male patient, which was clinically and radiologically misdiagnosed for orbital subperiostal hematoma. The patient underwent a surgical intervention to drain the hematoma when an orbital mass was found. The microscopic, immunologic, and genetic features of the tumor and the myelogram were in favor of LAM2, and the patient was started with chemotherapy with a favorable evolution within 18 months follow-up. Conclusion Orbital myeloid sarcoma usually exhibits clinical and radiological features that can be easily misleading, especially if it happens de novo or as the first manifestation of acute myeloid leukemia. Only a few isolated cases have reported and proposed trauma as a trigger event of the onset of this type of tumor proliferation, but further investigations and evidence are needed to support this hypothesis.

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