Remarks by Jonathan Schwartz

Schwartz, Jonathan B.

doi:10.1017/s0272503700065150

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Proc. annu. meet.- Am. Soc. Int. Law

1997

DOI: 10.1017/s0272503700065150

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Remarks by Jonathan Schwartz

Jonathan B. Schwartz

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2006

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“…ABX-EGF (Panitumumab) is another anti-EGFR MAb that has similar mechanism of action to cetuximab and is currently under investigations [20,21]. Another fully humanized MoAb in an advanced stage of clinical development is EMD72000.…”

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confidence: 99%

Anti-EGFR Strategy for Colorectal Cancer: Searching for the Real Target

Zaniboni¹,

Meriggi

2006

LDDD

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The epidermal growth factor receptor (EGFR) provides survival signals and is overexpressed in the majority of colorectal cancer. Cetuximab is a recombinant human/mouse monoclonal antibody(MoAb) against EGFR, clinically active in the treatment of human colorectal cancer. Unlike the predictable correlation of response to trastuzumab, another MoAb clinically active in a subgroup of breast cancer patients expressing HER-2/neu, responses to cetuximab in EGFR-expressing colorectal cancer is not predictable.The search for a reliable marker that would allow clinicians to select patients for cetuximab therapy remains a major challenge.

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confidence: 99%

Anti-EGFR Strategy for Colorectal Cancer: Searching for the Real Target

Zaniboni¹,

Meriggi

2006

LDDD

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Remarks by Jonathan Schwartz

Cited by 1 publication

References 0 publications

Anti-EGFR Strategy for Colorectal Cancer: Searching for the Real Target

Anti-EGFR Strategy for Colorectal Cancer: Searching for the Real Target

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