Remarkably selective and enantiodifferentiating sensing of histidine by a fluorescent homochiral Zn-MOF based on pyrene-tetralactic acid

Abstract

A highly luminescent and water-stable homochiral Zn-MOF, i.e., Zn-PLA, developed based on pyrene-tetraacetic, selectively senses histidine amongst all other amino acids and also differentiates d and l isomers, as revealed by quenching of the fluorescence of its aqueous suspension.

Entropically Favoured Assembly of Pyrazine‐Based Helical Fibers into Superstructures: Achiral/ Chiral Guest‐Induced Chirality Transformation

“…Fascinatingly,t he supercoiled 1:Ni 2+ ensemble that is favored by entropy undergoes further assembly and chirality transformation in the presence of d/l-histidine to generate the superhelix 1:Ni 2+ :d-histidine/ 1:Ni 2+ :l-histidine.A dditionally,t he supercoiled 1:Ni 2+ ensemble exhibits ah igher affinity for d-histidine over lhistidine and the enantioselective ratio (K d /K l )was found to be 2.99, which is remarkable in comparison to other literature report. [21] This is the first report which demonstrates the assembly of pyrazine-based building blocks with l-alanine as ac hiral handle into ah elical system for the development of as upercoiled helical system in presence of achiral stimuli (Ni 2+ ions). This report also demonstrates further assembly of supercoiled helical systems into higher-order superhelices using d/l-histidine as external stimuli in aqueous media.…”

Zinc‐Coordinated Hierarchical Organization of Ligand‐Stabilized Gold Nanoclusters for Chiral Recognition and Separation

“…This is particularly relevant to chiral drug development, which is of great interest to the healthcare industry. Chiral recognition of amino acids has stimulated immense research interest in recent times . A prominent example in this regard would be tryptophan (Trp); the l ‐isomer is predominant in biological systems, whereas the d ‐isomer is an indication of disease and ageing .…”

Mercuric Ion Sensing by an Overlapping β‐turn Containing Peptide

“…The emission maximum for the peptide is at 495 nm. We suppose that the structure of the peptide is appreciably rigidified upon Hg 2+ binding resulting in a significant fluorescence enhancement . This phenomenon is not new but can be put to good use to study mercury toxicity in live cell cultures.…”

“…We suppose that the structure of the peptide is appreciably rigidified upon Hg 2 + binding resulting in a significant fluorescence enhancement. [22] This phenomenon is not new but can be put to good use to study mercury toxicity in live cell cultures. This also open a possibility in the design of similar such entities to study Hg 2 + -protein interactions that were previously thought to be manifesting themselves via sulphur atoms and methyl mercury type of interactions.…”