Remaining teeth, oral dryness and dental health habits in middle‐aged Norwegian rheumatoid arthritis patients

Arneberg, Pål; Bjertness, Espen; Storhaug, Kari; Glennås, A; Bjerkhoel, Frithjof

doi:10.1111/j.1600-0528.1992.tb01702.x

Cited by 27 publications

(25 citation statements)

References 13 publications

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“…In another minor study29 ST was reduced in 30% of RA patients. The prevalence of oral SISY was 6% when spontaneously reported by RA patients,2 32% when recorded as responses to questions,9 and 53% in a study considering frequent and periodical symptoms together 10. Such different results may be partly explained by different approaches in the assessment of SISY.…”

Section: Discussionmentioning

confidence: 93%

“…Ocular or oral sicca symptoms (SISY) in RA patients have previously been reported in 18–25%7 8 and 6–53%2 9 10 of the patients, respectively. In a recently published pilot study11 we found a high prevalence of SISY in RA patients, but also an association with xerogenic medication—that is, medication with the capacity to induce dryness, for example xerostomia.…”

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confidence: 95%

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Sicca symptoms, saliva and tear production, and disease variables in 636 patients with rheumatoid arthritis

Uhlig

Kvien

Jensen

et al. 1999

Annals of the Rheumatic Diseases

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Objectives-(1) To estimate the prevalence of ocular and oral sicca symptoms (SISY) or reduced saliva and tear production; (2) to relate SISY and sicca signs to measures of disease activity, damage, and health status; and (3) to examine the relation between symptoms and objective signs of tear and saliva production in a large sample of representative patients with rheumatoid arthritis (RA). Methods-From an unselective county RA register 636 patients (age 20-70 years) were examined with Schirmer-I test (ST), unstimulated whole saliva (UWS), questions on SISY and measures of disease activity, damage and health status. Results-Ocular sicca symptoms were reported in 38%, oral sicca symptoms in 50%, and a combination of both in 27%. Reduced tear production was present in 29%, and reduced saliva production in 17%. The minimum frequency of secondary Sjögren's syndrome was 7%. Measurements of exocrine disease manifestations were to variable extents bivariately correlated to disease activity measures, physical disability, pain, fatigue, and use of xerogenic drugs, but were not related to deformed joint count. Multivariate analyses revealed significant associations between disease activity and reduced saliva production. Only weak associations between SISY and tear or saliva production were observed. Conclusion-SISY, reduced tear and saliva production were frequent extraarticular manifestations in RA, but were only weakly intercorrelated. High disease activity and at least two SISY were independent predictors of reduced saliva production, but ocular and oral dryness did not seem to be closely related to disease duration, disease activity, damage or health status.

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 95%

Sicca symptoms, saliva and tear production, and disease variables in 636 patients with rheumatoid arthritis

Uhlig

Kvien

Jensen

et al. 1999

Annals of the Rheumatic Diseases

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“…Periodontitis has also been found to be more severe in patients with RA, who exhibit greater alveolar bone loss [32]. In addition, disability of the extremities and reduced manual dexterity caused by RA may impair oral hygiene and increase the risk for periodontitis and tooth loss [33]. Manifesting high levels of cytokines, such as IL-1 β , IL-6, and TNF- α , periodontitis has an immunologic profile similar to that of RA and both diseases are associated with elevated concentrations of matrix metalloproteinases (MMPs) and low concentrations of tissue inhibitors of MMP (TIMPs) [13].…”

Section: Discussionmentioning

confidence: 99%

Effects of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis

Jung

Han

Hwang

et al. 2018

BioMed Research International

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Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory diseases and periodontitis is known to be more common and more severe in patients with RA. Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and periodontitis, this prospective study aimed to evaluate the adjunctive effect of csDMARDs on response to nonsurgical periodontal treatment in patients with RA. Thirty-two patients with RA (RA group) and 32 systemically healthy patients (control group) with periodontitis were included in this study. The RA group patients were treated with csDMARDs, such as methotrexate, hydroxychloroquine, and sulfasalazine. Conventional nonsurgical periodontal treatment with scaling and root planing was performed in both groups. The extent and severity of periodontitis were evaluated by plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at baseline and 4 weeks after periodontal treatment. There was no statistically significant difference of periodontal parameters between the RA and control groups at baseline. Four weeks after scaling and root planing, PD reduction, and CAL gain were higher in the RA group treated with csDMARDs compared to the control group, and the difference was statistically significant (P = 0.006 and 0.003, respectively). A post hoc analysis of the RA group showed no statistically significant difference on the response to nonsurgical periodontal treatment in multiple csDMARDs therapy and addition of NSAIDs and/or steroids to csDMARDs. In patients with RA, csDMARDs showed beneficial effect on periodontal clinical parameters following the nonsurgical periodontal treatment.

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“…It has been hypothesized that PD is associated with subsequent development of RA, but studies on this association have reported conflicting results and no prospective study has been conducted. Two cross-sectional studies and a retrospective case-control study showed no association(6–8). Other studies have found a higher prevalence of PD and tooth loss among patients with existing RA(9–15).…”

Section: Introductionmentioning

confidence: 92%

A Prospective Study of Periodontal Disease and Risk of Rheumatoid Arthritis

Arkema

Karlson²,

Costenbader³

2010

J Rheumatol

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Objectives-To test for an association between periodontal disease (PD) and incident rheumatoid arthritis (RA) in a large prospective cohort.Methods-We conducted a prospective analysis of history of periodontal surgery, tooth loss and risk of RA among 81,132 women in the Nurses' Health Study prospective cohort. Periodontal surgery and tooth loss were used as proxies for history of PD. There were 292 incident RA cases diagnosed from 1992 to 2004. Information on periodontal surgery and tooth loss in the past two years was collected by questionnaire in 1992. Cox proportional hazards models were used to assess relationships between periodontal surgery, tooth loss and RA risk adjusting for age, smoking, number of natural teeth, BMI, parity, breastfeeding, postmenopausal status, postmenopausal hormone use, father's occupation and alcohol intake.Results-Compared with those who reported no history of periodontal surgery or tooth loss, women with periodontal surgery or tooth loss did not have a significantly elevated risk of RA in multivariableadjusted models (RR=1.24; 95% CI (0.83, 1.83) and RR=1.18; 95% CI (0.47, 2.95), respectively). In analyses stratified by ever and never smokers, ever smokers with periodontal surgery had an increased risk that was also non-significant. Those with severe PD (both history of periodontal surgery and tooth loss) did not have a significant increased risk.Conclusion-In this large cohort of U.S. women, there is no evidence of an increased risk of later onset RA among those with a history of periodontal surgery and/or tooth loss.

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Remaining teeth, oral dryness and dental health habits in middle‐aged Norwegian rheumatoid arthritis patients

Cited by 27 publications

References 13 publications

Sicca symptoms, saliva and tear production, and disease variables in 636 patients with rheumatoid arthritis

Sicca symptoms, saliva and tear production, and disease variables in 636 patients with rheumatoid arthritis

Effects of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis

A Prospective Study of Periodontal Disease and Risk of Rheumatoid Arthritis

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