REM sleep parameters in the discrimination of probable Alzheimer's disease from old-age depression

Bahro, Marcel; Riemann, Dieter; Stadtmüller, G.; Berger, Thomas; Gattaz, Wagner F.

doi:10.1016/0006-3223(93)90239-a

Cited by 21 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The length of REM latency in AD patients compared to controls is controversial. Some studies reported that AD patients had a longer REM latency [30,31], but others reported no significant differences [28,29]. At any rate, the alteration of REM sleep parameters may be specific to AD, while non-REM stage II may be related to declarative memory formation in dementia independent of subtypes [31].…”

Section: Mci-mci Mci-ad P Valuementioning

confidence: 99%

See 1 more Smart Citation

Alterations in Rapid Eye Movement Sleep Parameters Predict for Subsequent Progression from Mild Cognitive Impairment to Alzheimer’s Disease

Shinno¹,

Ishikawa²

2016

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

Objective: Mild cognitive impairment (MCI) refers to the clinical condition between normal aging and Alzheimer's disease (AD). Heterogeneity in this entity has also been recognized, and an accelerated rate of progression to AD was documented in some individuals diagnosed with MCI. It is important for the early detection of and intervention for AD to determine the clinical subtype of MCI with a high risk of progression to AD. Studies have demonstrated that deceased glucose metabolism or regional cerebral blood flow in the posterior cingulate may be associated with a higher risk of such progression. The aim of this study was to investigate whether any polysomnography (PSG) variables support the prediction of progression from MCI to AD.Methods: Twenty-four subjects with MCI were enrolled in this study. Clinical evaluation, cognitive screening tests, and PSG were carried out at the baseline. A diagnosis of MCI was made with standard criteria. Outcome measures were carried out to examine whether: 1) there was a significant cognitive decline, and 2) it progressed to AD according to the standard criteria for it. After a 2-year follow-up, subjects were divided into 2 groups. The MCI-AD group included subjects who progressed to AD, and the MCI-MCI group included those who did not meet the criteria for dementia. Basal PSG variables were compared between the groups.Results: Nineteen subjects completed the study. Six subjects (32%) progressed to AD within 2 years. Subjects in the MCI-AD group showed a shorter stage REM sleep (p=0.043), and a reduced REM density (p=0.043) at the baseline. Conclusion:Subjects who progressed to AD demonstrated altered REM sleep variables, yet they did not meet the criteria for clinically probable AD in the examination period. We consider that these properties may be associated with a higher risk of progression from MCI to AD.

show abstract

Section: Mci-mci Mci-ad P Valuementioning

confidence: 99%

“…Several studies and reviews suggested that patients with AD spent a shorter time in REM sleep [13]. REM densities have also been reported to be reduced in AD patients compared with those in elderly depressed subjects [28,29] and elderly controls [28]. The length of REM latency in AD patients compared to controls is controversial.…”

Section: Mci-mci Mci-ad P Valuementioning

confidence: 99%

Alterations in Rapid Eye Movement Sleep Parameters Predict for Subsequent Progression from Mild Cognitive Impairment to Alzheimer’s Disease

Shinno¹,

Ishikawa²

2016

J Alzheimers Dis Parkinsonism

View full text Add to dashboard Cite

show abstract

“…Looking at the control period, the symptom of waking after sleep onset was seen in all study subjects. Deep sleep (stages 3-4) and REM sleep time have also been reported to decrease and waking after sleep onset increases in healthy elderly individuals [23] and subjects with Alzheimer-type dementia in comparison to healthy subjects of the same age [24]. Waking after sleep onset is a major issue affecting the sleep of many elderly people and individuals with dementia, and inhalation aromatherapy alone was unable to improve WTASO in these subjects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Inhalation Aromatherapy on Symptoms of Sleep Disturbance in the Elderly with Dementia

Takeda

Watanuki

Koyama

2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

This study investigated the effects of inhalation aromatherapy on sleep disturbance in elderly individuals with dementia. In 19 subjects, normal sleep was observed for a 20-day control period, inhalation aromatherapy was then applied for a 20-day intervention period, and the control and intervention periods were compared. During the intervention period, essential oils were placed nightly on towels around the subjects' pillows. The measured sleep conditions were sleep latency, total sleep time, sleep efficacy, duration of the longest sustained sleep period, wake time after sleep onset, early morning awakening, total daytime sleep, and the Neuropsychiatric Inventory. Total sleep time was significantly longer in the intervention period than in the control period (p < 0.05). The duration of the longest sustained sleep period was significantly longer in the intervention period than in the control period (p < 0.05). Early morning awakening in the intervention period was significantly less compared to that in the control period (p < 0.05). Total daytime sleep could not be adequately measured and was omitted from the analysis. No significant differences in other sleep conditions were observed. These results indicated positive effects of inhalation aromatherapy on symptoms of sleep disturbance in elderly individuals with dementia.

show abstract

“…14 Some studies have shown that REM sleep decreases in patients with AD, possibly reflecting a deficiency in acetylcholine. 15,16 REM sleep disturbance, which could result from damage to pedunculopontine tegmentum cholinergic neurons, is also observed in animals with AD. 17 Growing evidence suggests that nitric oxide (NO) is also important for sleep regulation.…”

Section: Introductionmentioning

confidence: 95%

Expression of inducible nitric oxide synthase (iNOS) and period 1 (PER1) clock gene products in different sleep stages of patients with cognitive impairment

Tseng

Liu

Yuan

et al. 2010

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

REM sleep parameters in the discrimination of probable Alzheimer's disease from old-age depression

Cited by 21 publications

References 15 publications

Alterations in Rapid Eye Movement Sleep Parameters Predict for Subsequent Progression from Mild Cognitive Impairment to Alzheimer’s Disease

Alterations in Rapid Eye Movement Sleep Parameters Predict for Subsequent Progression from Mild Cognitive Impairment to Alzheimer’s Disease

Effects of Inhalation Aromatherapy on Symptoms of Sleep Disturbance in the Elderly with Dementia

Expression of inducible nitric oxide synthase (iNOS) and period 1 (PER1) clock gene products in different sleep stages of patients with cognitive impairment

Contact Info

Product

Resources

About